| Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells. | Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells.
Zhang W, Huang F, Ding X, Qin J, Wang W, Luo L. | 05/29/2024 |
| Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome. | Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Chen Y, Liu Z, Chen H, Wen Y, Fan L, Luo M. | 05/29/2024 |
| Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system. | Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Reisch F, Heydeck D, Schäfer M, Rothe M, Yang J, Stehling S, Püschel GP, Kuhn H., Free PMC Article | 12/6/2023 |
| Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15. | Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Zhang Q, Du G, Tong L, Guo X, Wei Y. | 09/7/2023 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis. | Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis.
Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X, Chen Z, Ai D, Zhu Y, Zhang X. | 08/25/2023 |
| Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma. | Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma.
Makullah M, Ellis DA, Jones M, Steele C., Free PMC Article | 07/20/2023 |
| 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis. | 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.
Jackson CD, Hilliard KA, Brown CR., Free PMC Article | 05/13/2023 |
| P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. | P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.
Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB, Kapralov AA, Shurin GV, Samovich SN, St Croix CM, Watkins SC, Wenzel SE, Mallampalli RK, Greenberger JS, Bayır H, Kagan VE, Tyurina YY., Free PMC Article | 04/2/2022 |
| 12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study. | 12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study.
Choudhary R, Kumar M, Katyal A., Free PMC Article | 03/12/2022 |
| Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis. | Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
Zhao J, Wu Y, Liang S, Piao X. | 03/5/2022 |
| 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. | 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction.
Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB., Free PMC Article | 02/19/2022 |
| Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney. | Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney.
Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E., Free PMC Article | 11/13/2021 |
| 12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice. | 12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice.
Miyata J, Yokokura Y, Moro K, Arai H, Fukunaga K, Arita M., Free PMC Article | 10/30/2021 |
| 12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation. | 12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.
Sezin T, Ferreirós N, Jennrich M, Ochirbold K, Seutter M, Attah C, Mousavi S, Zillikens D, Geisslinger G, Sadik CD. | 10/16/2021 |
| Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway. | Gigantol ameliorates CCl(4)-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway.
Xue Y, Deng Q, Zhang Q, Ma Z, Chen B, Yu X, Peng H, Yao S, Liu J, Ye Y, Pan G., Free PMC Article | 05/8/2021 |
| Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype. | Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype.
Rademacher M, Kuhn H, Borchert A. | 05/1/2021 |
| Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis. | Alox12/15 Deficiency Exacerbates, While Lipoxin A(4) Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.
Queck A, Fink AF, Sirait-Fischer E, Rüschenbaum S, Thomas D, Snodgrass RG, Geisslinger G, Baba HA, Trebicka J, Zeuzem S, Weigert A, Lange CM, Brüne B., Free PMC Article | 04/17/2021 |
| Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway. | Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway.
Ogawa M, Ishihara T, Isobe Y, Kato T, Kuba K, Imai Y, Uchino Y, Tsubota K, Arita M. | 03/13/2021 |
| Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model. | Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Sultan M, Ben-Shushan D, Peled M, Kamari Y, Isman S, Barshack I, Kuban RJ, Kühn H, Harats D, Shaish A. | 02/6/2021 |
| Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation. | Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation.
Jiang YN, Guo YZ, Lu DH, Pan MH, Liu HZ, Jiao GL, Bi W, Kurihara H, Li YF, Duan WJ, He RR, Yao XS. | 02/2/2021 |
| Knocking-out of 12/15-LO reduced levels of renal inflammation and injury markers elicited by lipopolysaccharide injection. | A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.
Elmarakby AA, Ibrahim AS, Katary MA, Elsherbiny NM, El-Shafey M, Abd-Elrazik AM, Abdelsayed RA, Maddipati KR, Al-Shabrawey M., Free PMC Article | 03/7/2020 |
| The authors show that Alox15 mediates production of resolvin D2 that is required to maintain skin integrity by suppressing dermal inflammation. | Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Kim SN, Akindehin S, Kwon HJ, Son YH, Saha A, Jung YS, Seong JK, Lim KM, Sung JH, Maddipati KR, Lee YH., Free PMC Article | 11/9/2019 |
| 12/15-LOX is overexpressed in macrophages after SAH in mice, and inhibition of the 12/15-LOX pathway decreases brain injury and improves neurological outcome. This study suggests 12/15-LOX as a novel therapeutic target to limit brain injury after SAH. | Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Gaberel T, Gakuba C, Zheng Y, Lépine M, Lo EH, van Leyen K., Free PMC Article | 10/19/2019 |
| these results indicate that Alox12 loss activates a compensatory increase in Alox15 that sensitizes mouse beta cells to oxidative stress. | Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK., Free PMC Article | 10/19/2019 |
| Our study demonstrated that hypoxia increases the expression of MMP-2 and MMP-9 through the 15-lipoxygenase/15-HETE pathway, and that MMP-2 and MMP-9 promote PAEC angiogenesis. These findings suggest that MMP-2 and MMP-9 may serve as new potential therapeutic targets for the treatment of pulmonary arterial hypertension (PAH). | MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells.
Liu Y, Zhang H, Yan L, Du W, Zhang M, Chen H, Zhang L, Li G, Li J, Dong Y, Zhu D. | 09/14/2019 |