| MTA1, a metastasisassociated protein, in endothelial cells is an essential molecule for angiogenesis. | MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis.
Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F., Free PMC Article | 02/26/2022 |
| Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate. | Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate.
Xu Z, Zou C, Guo M, Bian H, Zhao W, Wang J. | 02/6/2021 |
| MTA1 participates in the formation of pulmonary capillaries via stabilization of HIF-1alpha. This finding sheds new light on the function of MTA1 in lung development. | Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice.
Qin JH, Ke ZY, Zhou Q, Wang L, Liang Y, Wang YM, Yang T, Gao X, Ye J, Kumar R, Wang RA., Free PMC Article | 05/19/2018 |
| Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression. | Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells.
Marzook H, Deivendran S, George B, Reshmi G, Santhoshkumar TR, Kumar R, Pillai MR. | 10/14/2017 |
| the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 pathways. | Neuroprotective effects of a chromatin modifier on ischemia/reperfusion neurons: implication of its regulation of BCL2 transactivation by ERα signaling.
Guo J, Zhang T, Yu J, Li HZ, Zhao C, Qiu J, Zhao B, Zhao J, Li W, Zhao TZ. | 03/11/2017 |
| Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression. | Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer.
Dhar S, Kumar A, Zhang L, Rimando AM, Lage JM, Lewin JR, Atfi A, Zhang X, Levenson AS., Free PMC Article | 02/18/2017 |
| Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS-induced acute lung injury, by selectively promoting the expression of NF-kappaB-regulated inflammatory cytokines. | Repression of a chromatin modifier aggravates lipopolysaccharide-induced acute lung injury in mouse.
Chen JK, Wang WC, Zang L, Zhao J, Li W, Jiang T. | 08/6/2016 |
| MTA1 was regulated by HIF-1alpha in hypoxia circumstance to suppress osteoblast differentiation. | Hypoxia-induced MTA1 promotes MC3T3 osteoblast growth but suppresses MC3T3 osteoblast differentiation.
Liu T, Zou W, Shi G, Xu J, Zhang F, Xiao J, Wang Y., Free PMC Article | 03/5/2016 |
| MTA1 levels were increased in monosodium urate crystal-induced inflammation. | The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in self-limitation of monosodium urate crystal-induced inflammation by upregulating TGF-β1.
Yen JH, Lin LC, Chen MC, Sarang Z, Leong PY, Chang IC, Hsu JD, Chen JH, Hsieh YF, Pallai A, Köröskényi K, Szondy Z, Tsay GJ., Free PMC Article | 01/23/2016 |
| The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice. | [MTA1-specific shRNA inhibits the growth and metastasis of mouse xenograft of laryngeal squamous cell carcinoma].
Liu Z, Zhou J, Wang Z, Bai L. | 01/16/2016 |
| Data suggest that nuclear metastasis-associated protein 1 (MTA1) is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers. | The subcellular distribution and function of MTA1 in cancer differentiation.
Liu J, Xu D, Wang H, Zhang Y, Chang Y, Zhang J, Wang J, Li C, Liu H, Zhao M, Lin C, Zhan Q, Huang C, Qian H., Free PMC Article | 05/16/2015 |
| this study reports the potential signaling events related to up-regulation of metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells injury. | A chromatin modifier regulates Sertoli cell response to mono-(2-ethylhexyl) phthalate (MEHP) via tissue inhibitor of metalloproteinase 2 (TIMP2) signaling.
Zhang C, Lai JH, Hu B, Zhang S, Zhao J, Li W. | 01/17/2015 |
| MTA1 has an important role in the maintenance of circadian rhythmicity. | Metastasis-associated protein 1 is an integral component of the circadian molecular machinery.
Li DQ, Pakala SB, Reddy SD, Peng S, Balasenthil S, Deng CX, Lee CC, Rea MA, Kumar R. | 05/3/2014 |
| the MTA1/NFkappaB/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after Sertoli cell injury. | Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: probably an indirect action via the regulation of NFκB/FasL circuitry.
Chen S, Dong Y, Xu C, Jiang L, Chen Y, Jiang C, Hou W, Li W. | 02/15/2014 |
| MTA1 is a major contributor to prostate tumor malignant progression. | Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer.
Li K, Dias SJ, Rimando AM, Dhar S, Mizuno CS, Penman AD, Lewin JR, Levenson AS., Free PMC Article | 08/31/2013 |
| Data indicate that metastasis tumor antigen 1 (MTA1)-dependent stimulation of STAT3 transcription through action on the MTA1/STAT3/Pol II coactivator complex. | MTA1 promotes STAT3 transcription and pulmonary metastasis in breast cancer.
Pakala SB, Rayala SK, Wang RA, Ohshiro K, Mudvari P, Reddy SD, Zheng Y, Pires R, Casimiro S, Pillai MR, Costa L, Kumar R., Free PMC Article | 08/31/2013 |
| The changes of the expression sites and quantity of MTA1 in the DEN-induced carcinogenesis of mouse liver indicate that MTA1 may play an important role in the whole process of liver carcinogenesis. | [Expression and potential role of metastasis-associated protein 1 in the induced carcinogenesis of mouse liver].
Xin B, Wang XY, Li Y, Qin JH, Ma XJ, Yin JP, Wang RA. | 01/12/2013 |
| Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function. | Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.
Reddy SD, Pakala SB, Molli PR, Sahni N, Karanam NK, Mudvari P, Kumar R., Free PMC Article | 11/17/2012 |
| The fine coordination between MTA1 and p53 in pachytene spermatocytes upon hyperthermal stimulation, was investigated. | Transient protection from heat-stress induced apoptotic stimulation by metastasis-associated protein 1 in pachytene spermatocytes.
Li W, Wu ZQ, Zhao J, Guo SJ, Li Z, Feng X, Ma L, Zhang JS, Liu XP, Zhang YQ., Free PMC Article | 02/18/2012 |
| findings suggest that MTA1 status plays an important role in conferring an optimal cytokine response in mice following infection with Opisthorchis viverrini and is a major player in parasite-induced cholangiocarcinoma in humans | Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans.
Nair SS, Bommana A, Pakala SB, Ohshiro K, Lyon AJ, Suttiprapa S, Periago MV, Laha T, Hotez PJ, Bethony JM, Sripa B, Brindley PJ, Kumar R., Free PMC Article | 01/28/2012 |
| The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer. | The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer.
Nair SS, Bommana A, Bethony JM, Lyon AJ, Ohshiro K, Pakala SB, Rinaldi G, Keegan B, Suttiprapa S, Periago MV, Hotez PJ, Brindley PJ, Kumar R., Free PMC Article | 10/1/2011 |
| Gene profiling of MTA1 identifies novel gene targets and functions. | Gene profiling of MTA1 identifies novel gene targets and functions.
Ghanta KS, Li DQ, Eswaran J, Kumar R., Free PMC Article | 09/3/2011 |
| findings reveal an obligatory coregulatory role of MTA1 in the regulation of TG2 expression and of the MTA1-TG2 pathway, at least in part, in LPS modulation of the NF-kappaB signaling in stimulated macrophages | MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response.
Ghanta KS, Pakala SB, Reddy SD, Li DQ, Nair SS, Kumar R., Free PMC Article | 05/7/2011 |
| Data suggest that the expression of MTA1 protein could be regulated by androgen pathway and closely associated with the postnatal development of the epididymis, and that this gene may play a potential role in sperm maturation and fertility. | Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis.
Ma L, Li W, Zhu HP, Li Z, Sun ZJ, Liu XP, Zhao J, Zhang JS, Zhang YQ., Free PMC Article | 04/30/2011 |
| MTA1 regulation of MyD88 may constitute at least one of the mechanisms by which MTA1 stimulates LPS-induced NF-kappaB signaling in stimulated macrophages. | MTA1 coregulator regulates LPS response via MyD88-dependent signaling.
Pakala SB, Reddy SDN, Bui-Nguyen TM, Rangparia SS, Bommana A, Kumar R., Free PMC Article | 11/27/2010 |