| Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. | Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
Wasilewska I, Majewski Ł, Adamek-Urbańska D, Mondal SS, Baranykova S, Gupta RK, Bielecki D, Winata CL, Kuznicki J. | 08/23/2023 |
| RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia. | RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB., Free PMC Article | 01/22/2022 |
| Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle. | Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
Jeong SY, Oh MR, Choi JH, Woo JS, Lee EH., Free PMC Article | 12/25/2021 |
| Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model. | Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
Deng M, Zhang Q, Wu Z, Ma T, He A, Zhang T, Ke X, Yu Q, Han Y, Lu Y., Free PMC Article | 07/3/2021 |
| Orai1 inhibitor STIM2beta regulates myogenesis by controlling SOCE dependent transcriptional factors. | Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors.
Kim KM, Rana A, Park CY., Free PMC Article | 10/24/2020 |
| These data indicate that STIM1 and STIM2 have differential roles in the production of IL-4, which are stimulus dependent. Furthermore, these results illustrate the vital role of STIM2 in basophils, which is often considered to be less important than STIM1. | Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.
Yoshikawa S, Oh-Hora M, Hashimoto R, Nagao T, Peters L, Egawa M, Ohta T, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Karasuyama H. | 07/4/2020 |
| mice deficient in both Stim1 and Stim2 in T cells (conditional double knockout [cDKO]) developed lymphoproliferative disorders and skin inflammation with a concomitant increase in serum IgG1 and IgE levels. | Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders.
Oh-Hora M, Lu X, Shiokawa M, Takayanagi H, Yamasaki S. | 01/4/2020 |
| Results indicate that preformed clusters of STIM and ORAI1 enable local Ca(2+) entry events in unstimulated cells. Upon TCR activation, NAADP-evoked Ca(2+) release through RYR1, in coordination with Ca(2+) entry through ORAI1 and STIM, rapidly increases the number of Ca(2+) microdomains, thereby initiating spread of Ca(2+) signals deeper into the cytoplasm to promote full T cell activation. | ORAI1, STIM1/2, and RYR1 shape subsecond Ca(2+) microdomains upon T cell activation.
Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH., Free PMC Article | 10/26/2019 |
| data show that loss of SOCE in enamel cells has substantial detrimental effects on gene expression, cell function, and the mineralization of dental enamel | Store-operated Ca(2+) entry controls ameloblast cell function and enamel development.
Eckstein M, Vaeth M, Fornai C, Vinu M, Bromage TG, Nurbaeva MK, Sorge JL, Coelho PG, Idaghdour Y, Feske S, Lacruz RS., Free PMC Article | 08/24/2019 |
| regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes | STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes.
Oh MR, Lee KJ, Huang M, Kim JO, Kim DH, Cho CH, Lee EH., Free PMC Article | 08/3/2019 |
| In contrast to wild-type controls or Stim2KO mice, isolated sweat glands from Stim1cKO mice showed no response to acetylcholine | STIM1, but not STIM2, Is the Calcium Sensor Critical for Sweat Secretion.
Cui CY, Noh JH, Michel M, Gorospe M, Schlessinger D., Free PMC Article | 03/16/2019 |
| We found that STIM2 is required for the stable expression of both LTP and LTD at CA3-CA1 hippocampal synapses. Altered plasticity in Stim2 cKO mice is associated with subtle alterations in the shape and density of dendritic spines in CA1 neurons. | STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses.
Yap KA, Shetty MS, Garcia-Alvarez G, Lu B, Alagappan D, Oh-Hora M, Sajikumar S, Fivaz M. | 02/24/2018 |
| neutrophil cytokine production required STIM2, but not STIM1, at least in part as a result of redox regulation of cytokine gene expression | STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.
Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA., Free PMC Article | 10/28/2017 |
| Expression of STIM2 protein rescued CaMKII activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo. | STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.
Popugaeva E, Pchitskaya E, Speshilova A, Alexandrov S, Zhang H, Vlasova O, Bezprozvanny I., Free PMC Article | 03/26/2016 |
| SOCE blockers or ablation of STIM1, STIM2, or Orai1 severely impaired nucleotide-induced migration and phagocytosis in microglia. | STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia.
Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. | 10/31/2015 |
| The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state. | Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.
Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX., Free PMC Article | 07/25/2015 |
| STIM1, STIM2, and CRAC channel function play distinct but synergistic roles in CD4+ and CD8+ T cells during antiviral immunity | CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2.
Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S., Free PMC Article | 02/14/2015 |
| Stim2 plays a moderate role in the development of autoinmune responses in a murine model of EAE, stimulating the proliferation of lymphocytes and the production of IFN-gamma/IL-17 by neuroantigen-specific T cells. | Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation.
Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B, Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B. | 08/11/2014 |
| Using mice lacking STIM1 and its homologue STIM2, authors find that store-operated calcium entry in CD8(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth. | STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells.
Weidinger C, Shaw PJ, Feske S., Free PMC Article | 03/15/2014 |
| STIM1 and STIM2-mediated store-operated Ca2+ influx, leading to efficient activation of NFAT (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells. | Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
Oh-Hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H., Free PMC Article | 08/3/2013 |
| STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. | STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome.
Cheng KT, Alevizos I, Liu X, Swaim WD, Yin H, Feske S, Oh-hora M, Ambudkar IS., Free PMC Article | 12/8/2012 |
| show that endoplasmic reticulum calcium sensors STIM1- and STIM2-induced store-operated Ca(2+) influx is critical for B cell regulatory function | The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production.
Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T, Baba Y. | 07/30/2011 |
| Absence of STIM2 in mouse embryonic fibroblasts results in a decreased store-operated calcium ion entry, although this inhibition is less pronounced than for STIM1. | STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling.
Decuypere JP, Monaco G, Kiviluoto S, Oh-hora M, Luyten T, De Smedt H, Parys JB, Missiaen L, Bultynck G. | 07/2/2011 |
| both STIM1 and STIM2 are critical for T-cell function and autoimmunity in vivo. | T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
Ma J, McCarl CA, Khalil S, Lüthy K, Feske S., Free PMC Article | 01/1/2011 |
| STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis. | Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation.
Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B, Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B. | 03/15/2010 |