| PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein. | PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein.
Johnson SM, Bao H, McMahon CE, Chen Y, Burr SD, Anderson AM, Madeyski-Bengtson K, Lindén D, Han X, Liu J., Free PMC Article | 06/14/2024 |
| Impact of PNPLA3 I148M on alpha-1 antitrypsin deficiency-dependent liver disease progression. | Impact of PNPLA3 I148M on alpha-1 antitrypsin deficiency-dependent liver disease progression.
Volkert I, Fromme M, Schneider C, Candels L, Lindhauer C, Su H, Thorhauge K, Pons M, Mohamed MR, Schneider KM, Strnad P, Trautwein C. | 03/20/2024 |
| Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals. | Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals.
Su H, Haque M, Becker S, Edlund K, Duda J, Wang Q, Reißing J, Marschall HU, Candels LS, Mohamed M, Sjöland W, Liao L, Drexler SA, Strowig T, Rahnenführer J, Hengstler JG, Hatting M, Trautwein C. | 09/12/2023 |
| The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats. | The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.
Patsenker E, Thangapandi VR, Knittelfelder O, Palladini A, Hefti M, Beil-Wagner J, Rogler G, Buch T, Shevchenko A, Hampe J, Stickel F. | 09/17/2022 |
| RORalpha regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice. | RORα regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice.
Han YH, Kim HJ, Lee MO. | 08/14/2021 |
| Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. | Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Tardelli M, Bruschi FV, Fuchs CD, Claudel T, Auer N, Kunczer V, Ronda OAHO, Verkade HJ, Stojakovic T, Scharnagl H, Trauner M., Free PMC Article | 04/17/2021 |
| these data showed previously uncovered roles of Phf16 and Pnpla3 in adipogenesis, highlighting the potential of using phytochemicals for further investigation of adipocyte biology. | Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.
Chang SH, Yun UJ, Choi JH, Kim S, Lee AR, Lee DH, Seo MJ, Panic V, Villanueva CJ, Song NJ, Park KW., Free PMC Article | 06/20/2020 |
| The ASO-mediated silencing of Pnpla3 reduced liver steatosis in homozygous Pnpla3 148M/M knock-in mutant mice but not in wild-type littermates fed a steatogenic high-sucrose diet. | Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.
Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad P, Romeo S., Free PMC Article | 04/18/2020 |
| results show that the steatosis associated with PNPLA3(148M) is caused by accumulation of PNPLA3 on LDs. | Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis.
BasuRay S, Wang Y, Smagris E, Cohen JC, Hobbs HH., Free PMC Article | 03/21/2020 |
| conclude that the fatty liver disease associated with genetic variation in PNPLA3 is not related to the enzyme's role in remodeling lipid droplets. | Patatin-like phospholipase domain–containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.
Mitsche MA, Hobbs HH, Cohen JC., Free PMC Article | 02/2/2019 |
| Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking. | Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation.
Restrepo RJ, Lim RW, Korthuis RJ, Shukla SD., Free PMC Article | 02/10/2018 |
| 148M variant disrupts ubiquitylation and proteasomal degradation | The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation.
BasuRay S, Smagris E, Cohen JC, Hobbs HH., Free PMC Article | 10/7/2017 |
| Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis. | Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis.
Smagris E, BasuRay S, Li J, Huang Y, Lai KM, Gromada J, Cohen JC, Hobbs HH., Free PMC Article | 03/21/2015 |
| rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent. | Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.
Trépo E, Nahon P, Bontempi G, Valenti L, Falleti E, Nischalke HD, Hamza S, Corradini SG, Burza MA, Guyot E, Donati B, Spengler U, Hillon P, Toniutto P, Henrion J, Franchimont D, Devière J, Mathurin P, Moreno C, Romeo S, Deltenre P. | 08/9/2014 |
| PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake | Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH., Free PMC Article | 01/26/2013 |
| adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids | Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes.
Dubuquoy C, Robichon C, Lasnier F, Langlois C, Dugail I, Foufelle F, Girard J, Burnol AF, Postic C, Moldes M. | 11/12/2011 |
| data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice. | Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.
Basantani MK, Sitnick MT, Cai L, Brenner DS, Gardner NP, Li JZ, Schoiswohl G, Yang K, Kumari M, Gross RW, Zechner R, Kershaw EE., Free PMC Article | 05/7/2011 |
| Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice. | Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.
Chen W, Chang B, Li L, Chan L., Free PMC Article | 10/23/2010 |
| Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1, SPOT14, and SCD1. | The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status.
Hoekstra M, Li Z, Kruijt JK, Van Eck M, Van Berkel TJ, Kuiper J. | 06/14/2010 |
| data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo | Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.
Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS., Free PMC Article | 01/21/2010 |