| Anti-Mullerian hormone induces autophagy to preserve the primordial follicle pool in mice. | Anti-Müllerian hormone induces autophagy to preserve the primordial follicle pool in mice.
Lecot-Connan T, Boumerdassi Y, Magnin F, Binart N, Kamenický P, Sonigo C, Beau I. | 02/28/2024 |
| Serum Anti-Mullerian Hormone Is an Effective Indicator of Antral Follicle Counts but Not Primordial Follicle Counts. | Serum Anti-Müllerian Hormone Is an Effective Indicator of Antral Follicle Counts but Not Primordial Follicle Counts.
Zhou Y, Scott KL, Quin E, Pankhurst MW., Free PMC Article | 07/6/2023 |
| Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure. | Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
Jie H, Jinxiang W, Ye L, Jing Z, Iangqing ZX, Jinxiu H, Zian L, Xinghua P. | 07/16/2022 |
| Blocking estrogen-induced AMH expression is crucial for normal follicle formation. | Blocking estrogen-induced AMH expression is crucial for normal follicle formation.
Tanimoto R, Sekii K, Morohaku K, Li J, Pépin D, Obata Y., Free PMC Article | 09/18/2021 |
| Accelerated ovarian reserve depletion in female anti-Mullerian hormone knockout mice has no effect on lifetime fertilitydagger. | Accelerated ovarian reserve depletion in female anti-Müllerian hormone knockout mice has no effect on lifetime fertility†.
Guo R, Pankhurst MW. | 08/28/2021 |
| Exposure to MIS during the first six days of life, by inhibiting specification of the stroma, dysregulates paracrine signals necessary for uterine development, eventually resulting in apoptosis of the Misr2+ cells, uterine hypoplasia, and complete infertility in the adult female. | Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility.
Saatcioglu HD, Kano M, Horn H, Zhang L, Samore W, Nagykery N, Meinsohn MC, Hyun M, Suliman R, Poulo J, Hsu J, Sacha C, Wang D, Gao G, Lage K, Oliva E, Morris Sabatini ME, Donahoe PK, Pépin D., Free PMC Article | 02/29/2020 |
| These findings highlight a novel role for AMH in the development and function of GnRH neurons. | Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism.
Malone SA, Papadakis GE, Messina A, Mimouni NEH, Trova S, Imbernon M, Allet C, Cimino I, Acierno J, Cassatella D, Xu C, Quinton R, Szinnai G, Pigny P, Alonso-Cotchico L, Masgrau L, Maréchal JD, Prevot V, Pitteloud N, Giacobini P., Free PMC Article | 02/22/2020 |
| AMH's inhibitory actions are regulated at least in part by H19, likely via let-7, marking this ncRNA pair as important regulators of the establishment and maintenance of the follicular pool. | A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis.
Qin C, Xia X, Fan Y, Jiang Y, Chen Y, Zhang N, Uslu B, Johnson J, Kallen AN., Free PMC Article | 02/8/2020 |
| Moderate elevations in AMH levels can severely restrict reproductive output and the number of developing follicles in the ovary. This evidence suggests that early antral follicles are a target for AMH signaling, which may regulate early follicle survival. | Anti-Müllerian hormone overexpression restricts preantral ovarian follicle survival.
Pankhurst MW, Kelley RL, Sanders RL, Woodcock SR, Oorschot DE, Batchelor NJ. | 08/31/2019 |
| These results suggest that AMH acts on the Mullerian duct in male mice by exuding into the interstitium surrounding the testis cord and infiltrating through the cranial region from the testis to the mesonephros. | The mechanisms underlying the effects of AMH on Müllerian duct regression in male mice.
Yamamoto A, Omotehara T, Miura Y, Takada T, Yoneda N, Hirano T, Mantani Y, Kitagawa H, Yokoyama T, Hoshi N., Free PMC Article | 09/22/2018 |
| Surface plasmon resonance analysis showed no significant association between FS288 and AMHC , suggesting that FS288 indirectly regulates AMH signaling. Activin A, a direct target of FS288, did not itself induce reporter activity in P19 cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A may influence the response of some cell types to AMH. | Anti-Müllerian hormone signaling is influenced by Follistatin 288, but not 14 other transforming growth factor beta superfamily regulators.
Kawagishi Y, Pankhurst MW, Nakatani Y, McLennan IS. | 04/14/2018 |
| AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. | Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.
Cimino I, Casoni F, Liu X, Messina A, Parkash J, Jamin SP, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison AE, Prevot V, Giacobini P., Free PMC Article | 05/21/2016 |
| AMH and FOXL2 collaboratively work to reserve ovarian follicles. AMH is an endogenous target gene of FOXL2. | Positive cross talk between FOXL2 and antimüllerian hormone regulates ovarian reserve.
Park M, Suh DS, Lee K, Bae J. | 11/22/2014 |
| Up-regulation of SOX9 in sertoli cells from testiculopathic patients accounts for increasing anti-mullerian hormone expression via impaired androgen receptor signaling. | Up-regulation of SOX9 in sertoli cells from testiculopathic patients accounts for increasing anti-mullerian hormone expression via impaired androgen receptor signaling.
Lan KC, Chen YT, Chang C, Chang YC, Lin HJ, Huang KE, Kang HY., Free PMC Article | 08/9/2014 |
| Male mice require AMH to undergo normal social development. | The bed nucleus of the stria terminalis has developmental and adult forms in mice, with the male bias in the developmental form being dependent on testicular AMH.
Wittmann W, McLennan IS. | 07/5/2014 |
| Data show that Purkinje cells express receptors for Mullerian inhibiting substance (MIS), and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum. | The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian inhibiting substance/anti-Müllerian hormone.
Wittmann W, McLennan IS. | 02/18/2012 |
| MIS may be involved in anterograde rather than autocrine or retrograde regulation of neurons. | Müllerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons.
Clarkson AN, Talbot CL, Wang PY, MacLaughlin DT, Donahoe PK, McLennan IS., Free PMC Article | 11/5/2011 |
| FSH and cAMP stimulate AMH transcription by granulosa cells. FSH and LH have an additive effect, which may be important in polycystic ovary syndrome. | FSH and its second messenger cAMP stimulate the transcription of human anti-Müllerian hormone in cultured granulosa cells.
Taieb J, Grynberg M, Pierre A, Arouche N, Massart P, Belville C, Hesters L, Frydman R, Catteau-Jonard S, Fanchin R, Picard JY, Josso N, Rey RA, di Clemente N., Free PMC Article | 10/1/2011 |
| This suggests that MIS is one of the determinants of "boy"-specific behavior. | The sex bias in novelty preference of preadolescent mouse pups may require testicular Müllerian inhibiting substance.
Morgan K, Meredith J, Kuo JY, Bilkey DK, McLennan IS. | 09/10/2011 |
| Role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function. | Anti-Müllerian hormone (AMH): regulator and marker of ovarian function.
van Houten EL, Themmen AP, Visser JA. | 08/16/2010 |
| MIS may be a broad regulator of the subtle sex-linked biases in the nervous system | Müllerian inhibiting substance contributes to sex-linked biases in the brain and behavior.
Wang PY, Protheroe A, Clarkson AN, Imhoff F, Koishi K, McLennan IS., Free PMC Article | 01/21/2010 |
| the existence of an AMH-dependent signalling pathway in the brain leading to an overexpression of the serine-protease inhibitor, neuroserpin, and neuronal survival | Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin.
Lebeurrier N, Launay S, Macrez R, Maubert E, Legros H, Leclerc A, Jamin SP, Picard JY, Marret S, Laudenbach V, Berger P, Sonderegger P, Ali C, di Clemente N, Vivien D. | 01/21/2010 |
| Mullerian inhibiting substance regulates gonadotropin gene expression | Regulation of gonadotropin gene expression by Mullerian inhibiting substance.
Bédécarrats GY, O'Neill FH, Norwitz ER, Kaiser UB, Teixeira J., Free PMC Article | 01/21/2010 |
| a combination of increased oocyte degeneration and increased follicular atresia neutralizes the increased initial and cyclic recruitment in AMH null mice to a normal number of preovulatory follicles | Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-Müllerian hormone null mice.
Visser JA, Durlinger AL, Peters IJ, van den Heuvel ER, Rose UM, Kramer P, de Jong FH, Themmen AP. | 01/21/2010 |
| In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with the expression of MIS. | FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.
Anttonen M, Ketola I, Parviainen H, Pusa AK, Heikinheimo M. | 01/21/2010 |