| SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac. | SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac.
Lee HJ, Fenollar-Ferrer C, Isgrig K, Wang YX, Valente K, Eide J, Honda K, Chien WW, Petralia RS, Dong L, Friedman TB, Bonifacino JS, Griffith AJ, Roux I. | 10/10/2024 |
| High expression of AP2M1 correlates with worse prognosis by regulating immune microenvironment and drug resistance to R-CHOP in diffuse large B cell lymphoma. | High expression of AP2M1 correlates with worse prognosis by regulating immune microenvironment and drug resistance to R-CHOP in diffuse large B cell lymphoma.
Liu X, Zhao X, Yang J, Wang H, Piao Y, Wang L. | 01/21/2023 |
| AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability. | AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability.
Ganapathy AS, Saha K, Suchanec E, Singh V, Verma A, Yochum G, Koltun W, Nighot M, Ma T, Nighot P., Free PMC Article | 08/27/2022 |
| Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer. | Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer.
Song X, Li M, Wu W, Dang W, Gao Y, Bian R, Bao R, Hu Y, Hong D, Gu J, Liu Y., Free PMC Article | 10/9/2021 |
| Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma. | Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma.
Wu CC, Li H, Xiao Y, Deng WW, Sun ZJ. | 12/26/2020 |
| The knockdown of AP2M1 in the Dengue virus infected Huh7 cells displayed a reduction in the viral titer at 24 h post-infection. | Suppression of µ1 subunit of the adaptor protein complex 2 reduces dengue virus release.
Tongmuang N, Yasamut U, Noisakran S, Sreekanth GP, Yenchitsomanus PT, Limjindaporn T. | 06/6/2020 |
| AP2M1 expression values fulfills a sufficient role as a novel prognostic marker for hepatocellular carcinoma, especially in, alcohol or hepatitis C subgroups. | The AP2M1 gene expression is a promising biomarker for predicting survival of patients with hepatocellular carcinoma.
Cho SH, Pak K, Jeong DC, Han ME, Oh SO, Kim YH. | 04/11/2020 |
| A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. | A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.
Helbig I, Lopez-Hernandez T, Shor O, Galer P, Ganesan S, Pendziwiat M, Rademacher A, Ellis CA, Hümpfer N, Schwarz N, Seiffert S, Peeden J, Shen J, Štěrbová K, Hammer TB, Møller RS, Shinde DN, Tang S, Smith L, Poduri A, Krause R, Benninger F, Helbig KL, Haucke V, Weber YG, EuroEPINOMICS-RES Consortium, GRIN Consortium., Free PMC Article | 03/14/2020 |
| It has been shown that the cytoplasmic domains of furin bind the mu subunits of AP-1 and AP-2 in a phosphorylation-dependent manner. | Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes.
Singh R, Stoneham C, Lim C, Jia X, Guenaga J, Wyatt R, Wertheim JO, Xiong Y, Guatelli J., Free PMC Article | 03/9/2019 |
| AP2 has evolved as a key regulatory node to coordinate clarhtin-coated pit formation and cargo sorting and ensure high spatial and temporal regulation of cathrin-mediated endocytosis. | Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.
Kadlecova Z, Spielman SJ, Loerke D, Mohanakrishnan A, Reed DK, Schmid SL., Free PMC Article | 06/3/2017 |
| This study identified and confirmed adaptor protein 2 changes within the postsynaptic density in schizophrenia. | Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR. | 12/12/2015 |
| BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. | BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
Harris JL, Richards RS, Chow CW, Lee S, Kim M, Buck M, Teng L, Clarke R, Gardiner RA, Lavin MF., Free PMC Article | 06/21/2014 |
| We identify dynamin and the EAP-binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis. | Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.
Aguet F, Antonescu CN, Mettlen M, Schmid SL, Danuser G., Free PMC Article | 11/2/2013 |
| a conserved heretofore unrecognized YXXPhi motif (Phi is a bulky hydrophobic residue) within the core protein. This motif is homologous to sorting signals within host cargo proteins known to mediate binding of AP2M1 | Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.
Neveu G, Barouch-Bentov R, Ziv-Av A, Gerber D, Jacob Y, Einav S., Free PMC Article | 12/22/2012 |
| Arkadia complexes with clathrin adaptor AP2 mu2 subunit and regulates EGF signalling. | Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. | 03/26/2011 |
| These results suggest that AP-2 is essential for endocytic clathrin coated-pit and coated-vesicle formation. | Roles of AP-2 in clathrin-mediated endocytosis.
Boucrot E, Saffarian S, Zhang R, Kirchhausen T., Free PMC Article | 09/13/2010 |
| multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis. | Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Schäfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V., Free PMC Article | 03/1/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y. | 09/20/2009 |
| The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway. | The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.
Levecque C, Velayos-Baeza A, Holloway ZG, Monaco AP., Free PMC Article | 01/21/2010 |
| These findings demonstrate differences in internalization between the alpha1a- and alpha1b-AR and provide evidence that the lack of significant endocytosis of the alpha1a-AR is linked to its poor interaction with beta-arrestins as well as with AP50. | Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.
Stanasila L, Abuin L, Dey J, Cotecchia S. | 01/21/2010 |
| These results thus identify a novel type of AP-2 interaction determinant, support the notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef, and reveal a previously unrecognized diversity among dileucine sorting signals. | A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.
Lindwasser OW, Smith WJ, Chaudhuri R, Yang P, Hurley JH, Bonifacino JS., Free PMC Article | 01/21/2010 |
| Phosphorylation of AP-2 mu2 subunit is essential for Na+,K+-ATPase endocytosis in response to a variety of signals, such as dopamine or reactive oxygen species. | Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.
Chen Z, Krmar RT, Dada L, Efendiev R, Leibiger IB, Pedemonte CH, Katz AI, Sznajder JI, Bertorello AM., Free PMC Article | 01/21/2010 |
| AP-2 and clathrin participate in MHC-II molecule trafficking to antigen-processing compartments. | Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments.
McCormick PJ, Martina JA, Bonifacino JS., Free PMC Article | 01/21/2010 |
| V1H can function as an adaptor for interactions between Nef and AP-2. | Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.
Geyer M, Yu H, Mandic R, Linnemann T, Zheng YH, Fackler OT, Peterlin BM. | 01/21/2010 |
| AP-2 is completely dependent on both (D/E)xxxL(L/I) motifs and 20 YxxO motifs signals to mediate TCR internalization; AP2M1 interacts with tyrosine in CD3delta and CD3gamma | Plasticity and rigidity in adaptor protein-2-mediated internalization of the TCR:CD3 complex.
Szymczak AL, Vignali DA. | 01/21/2010 |