| Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc. | Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.
Ohnishi T, Tran V, Sao K, Ramteke P, Querido W, Barve RA, van de Wetering K, Risbud MV., Free PMC Article | 07/24/2023 |
| The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate. | The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate.
Szeri F, Niaziorimi F, Donnelly S, Fariha N, Tertyshnaia M, Patel D, Lundkvist S, van de Wetering K., Free PMC Article | 05/21/2022 |
| The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP. | The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.
Szeri F, Lundkvist S, Donnelly S, Engelke UFH, Rhee K, Williams CJ, Sundberg JP, Wevers RA, Tomlinson RE, Jansen RS, van de Wetering K., Free PMC Article | 09/12/2020 |
| our study provides evidence that ANK plays a critical role in the adipogenic/osteogenic fate decision of adult mesenchymal precursor cells | The role of the progressive ankylosis protein (ANK) in adipogenic/osteogenic fate decision of precursor cells.
Minashima T, Quirno M, Lee YJ, Kirsch T., Free PMC Article | 04/29/2017 |
| regulates the transport of inorganic pyrophosphate, and Ank knock-out mice feature a rapidly forming and thick cementum and increased cementum regeneration | Modulation of phosphate/pyrophosphate metabolism to regenerate the periodontium: a novel in vivo approach.
Rodrigues TL, Nagatomo KJ, Foster BL, Nociti FH, Somerman MJ., Free PMC Article | 04/14/2012 |
| Loss of Ank alters cementoblast gene expression and cervical cementum extracellular matrix composition. | The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition.
Foster BL, Nagatomo KJ, Bamashmous SO, Tompkins KA, Fong H, Dunn D, Chu EY, Guenther C, Kingsley DM, Rutherford RB, Somerman MJ., Free PMC Article | 02/11/2012 |
| the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms | Increased risk of temporomandibular joint closed lock: a case-control study of ANKH polymorphisms.
Huang B, Takahashi K, Sakata T, Kiso H, Sugai M, Fujimura K, Shimizu A, Kosugi S, Sato T, Bessho K., Free PMC Article | 02/4/2012 |
| Phe377del mutation in ANK causes impaired osteoblastogenesis and osteoclastogenesis resulting in hypomineralization and a high bone mass phenotype. | A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).
Chen IP, Wang L, Jiang X, Aguila HL, Reichenberger EJ., Free PMC Article | 05/28/2011 |
| ANK is a positive regulator of osteoblastic and osteoclastic differentiation events toward a mature osteoblastic and osteoclastic phenotype. | Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling.
Kim HJ, Minashima T, McCarthy EF, Winkles JA, Kirsch T., Free PMC Article | 11/27/2010 |
| Analyses on mineralized tissues showed no decrease in mineralization between ank/ank cementum vs. WT controls. Nanoindentation on enamel, dentin or cementum of ank/ank vs. WT molars revealed no significant difference in hardness and elastic modulus. | Structure and mechanical properties of Ank/Ank mutant mouse dental tissues--an animal model for studying periodontal regeneration.
Fong H, Foster BL, Sarikaya M, Somerman MJ., Free PMC Article | 04/19/2010 |
| endogenous expression of ANKH mRNA and protein in whole mouse kidney as well as mouse renal epithelial cell lines and a osteoblast cell line. | The pyrophosphate transporter ANKH is expressed in kidney and bone cells and colocalises to the primary cilium/basal body complex.
Carr G, Moochhala SH, Eley L, Vandewalle A, Simmons NL, Sayer JA. | 02/22/2010 |
| ANK expression and function in vitro and in vivo are repressed in hypoxic environments and that the effect is regulated by HIF-1. | Oxygen tension regulates the expression of ANK (progressive ankylosis) in an HIF-1-dependent manner in growth plate chondrocytes.
Zaka R, Dion AS, Kusnierz A, Bohensky J, Srinivas V, Freeman T, Williams CJ., Free PMC Article | 01/21/2010 |
| Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia. | Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia.
Chen IP, Wang CJ, Strecker S, Koczon-Jaremko B, Boskey A, Reichenberger EJ., Free PMC Article | 01/21/2010 |
| ANK is a positive regulator of differentiation events towards a mature osteoblastic phenotype. | Progressive ankylosis gene (ank) regulates osteoblast differentiation.
Kirsch T, Kim HJ, Winkles JA., Free PMC Article | 01/21/2010 |
| These results revealed a novel function of ANKH in the promotion of early erythroid differentiation and that ank/ank mice have lower serum levels of Epo than the normal littermates, and this is the likely cause of microcytosis in these mutant mice. | Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW. | 01/21/2010 |
| intra-renal and subcellular localisation of ANK is consistent with pyrophosphate export from collecting duct cells and supports a role for ANK in limiting intra-renal calcium-crystal formation | Expression and localisation of the pyrophosphate transporter, ANK, in murine kidney cells.
Carr G, Sayer JA, Simmons NL. | 01/21/2010 |
| Linked regulatory effects on extracellular PP(i) and OPN expression mediate the ability of PC-1 and ANK to regulate calcification. | Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression.
Johnson K, Goding J, Van Etten D, Sali A, Hu SI, Farley D, Krug H, Hessle L, Millán JL, Terkeltaub R. | 01/21/2010 |