| Annexin A5 ameliorates traumatic brain injury-induced neuroinflammation and neuronal ferroptosis by modulating the NF-kB/HMGB1 and Nrf2/HO-1 pathways. | Annexin A5 ameliorates traumatic brain injury-induced neuroinflammation and neuronal ferroptosis by modulating the NF-ĸB/HMGB1 and Nrf2/HO-1 pathways.
Gao Y, Zhang H, Wang J, Li F, Li X, Li T, Wang C, Li L, Peng R, Liu L, Cui W, Zhang S, Zhang J. | 02/4/2023 |
| Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH. | Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Xu F, Guo M, Huang W, Feng L, Zhu J, Luo K, Gao J, Zheng B, Kong LD, Pang T, Wu X, Xu Q., Free PMC Article | 07/10/2021 |
| Annexin A5 is essential for PKCtheta translocation during T-cell activation. | Annexin A5 is essential for PKCθ translocation during T-cell activation.
Hu Z, Li L, Zhu B, Huang Y, Wang X, Lin X, Li M, Xu P, Zhang X, Zhang J, Hua Z., Free PMC Article | 02/20/2021 |
| Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells. | Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells.
Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X. | 02/2/2021 |
| These results identify a novel role for ANXA5 specifically in the recognition and binding step of clearance phagocytosis, which is essential to retinal physiology. | Annexin A5 regulates surface αvβ5 integrin for retinal clearance phagocytosis.
Yu C, Muñoz LE, Mallavarapu M, Herrmann M, Finnemann SC., Free PMC Article | 07/18/2020 |
| CD4+ ANXA5+ T cells represent a novel unique Treg cell subset exhibiting similarities to conventional Treg cells but with a distinct phenotype and function. | Annexin V expression on CD4(+) T cells with regulatory function.
Bollinger AL, Bollinger T, Rupp J, Shima K, Gross N, Padayachy L, Chicheportiche R, Puga Yung GL, Seebach JD., Free PMC Article | 02/8/2020 |
| Anxa5 was able to mediate hepatocellular carcinoma carcinogenesis via integrin and MEK-ERK pathways. | Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways.
Sun X, Liu S, Wang J, Wei B, Guo C, Chen C, Sun MZ., Free PMC Article | 11/30/2019 |
| Anxa5 prevents bone overgrowth at the enthesis. | Annexin A5 Involvement in Bone Overgrowth at the Enthesis.
Shimada A, Ideno H, Arai Y, Komatsu K, Wada S, Yamashita T, Amizuka N, Pöschl E, Brachvogel B, Nakamura Y, Nakashima K, Mizukami H, Ezura Y, Nifuji A. | 10/26/2019 |
| AnxA5 treatment attenuates the post-ischemic inflammatory response and ameliorates LV remodeling which improves cardiac function three weeks after myocardial ischemia-reperfusion (MI-R) injury in hypercholesterolemic ApoE*3-Leiden mice. | Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.
de Jong RCM, Pluijmert NJ, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA., Free PMC Article | 10/5/2019 |
| Our results imply that ANXA5 plays a potential role in asthma pathogenesis and may be a promising marker for exacerbated bronchial asthma and exposure to air pollutants. | Annexin A5 Protein as a Potential Biomarker for the Diagnosis of Asthma.
Lee SH, Lee PH, Kim BG, Hong J, Jang AS. | 07/20/2019 |
| Study identified an alternative means of supplementing anticoagulation, through elevated ANXA5 expression. Micromolar Zn2+ stimulated ANXA5 expression in cell culture directly and alleviated RPL in AnxA5 genetically deficient mice, without notable toxicity effects. | Micromolar Zinc in Annexin A5 Anticoagulation as a Potential Remedy for RPRGL3-Associated Recurrent Pregnancy Loss.
Danisik H, Bogdanova N, Markoff A. | 04/20/2019 |
| Results show that despite its high levels in stereocilia, ANXA5 does not appear to play a unique functional role for the auditory and vestibular systems. | Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function.
Krey JF, Drummond M, Foster S, Porsov E, Vijayakumar S, Choi D, Friderici K, Jones SM, Nuttall AL, Barr-Gillespie PG., Free PMC Article | 05/26/2018 |
| Eight-week-old ApoE-/-mice were fed a western diet while being administered AnxA5 or control (M1234) for a total of 6 weeks. AnxA5 administration reduced plaque size in the aortic root as well as the aortic arch by 36% and 55% respectively | Annexin A5 reduces early plaque formation in ApoE -/- mice.
Stöhr R, Schurgers L, van Gorp R, Jaminon A, Marx N, Reutelingsperger C., Free PMC Article | 01/20/2018 |
| Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells via ERK2/c-Jun/p-c-Jun(Ser73) and ERK2/E-cadherin pathways. | Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin.
Sun X, Wei B, Liu S, Guo C, Wu N, Liu Q, Sun MZ. | 02/18/2017 |
| findings suggest that GnRH is necessary for constitutive ANXA5 expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types | Gonadotropin-releasing hormone is prerequisite for the constitutive expression of pituitary annexin A5.
Yonezawa T, Watanabe A, Kurusu S, Kawaminami M. | 10/8/2016 |
| As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. | ANXA5 level is linked to in vitro and in vivo tumor malignancy and lymphatic metastasis of murine hepatocarcinoma cell.
Peng B, Liu S, Guo C, Sun X, Sun MZ. | 10/1/2016 |
| These data suggest that AnxA2 and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles | Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells.
Genetos DC, Wong A, Weber TJ, Karin NJ, Yellowley CE., Free PMC Article | 12/19/2015 |
| annexin A5 may play a crucial role in cisplatin-induced toxicity by mediating the mitochondrial apoptotic pathway via the induction and oligomerization of VDAC. | Role of annexin A5 in cisplatin-induced toxicity in renal cells: molecular mechanism of apoptosis.
Jeong JJ, Park N, Kwon YJ, Ye DJ, Moon A, Chun YJ., Free PMC Article | 03/29/2014 |
| The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 expression and activity during heart failure. | An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart.
Tritsch E, Mallat Y, Lefebvre F, Diguet N, Escoubet B, Blanc J, De Windt LJ, Catalucci D, Vandecasteele G, Li Z, Mericskay M. | 01/4/2014 |
| double and opposite role of annexin A5 in regulating the endocytic and autophagic pathways and the fusion of autophagosomes with lysosomes and endosomes | Annexin A5 stimulates autophagy and inhibits endocytosis.
Ghislat G, Aguado C, Knecht E. | 06/8/2013 |
| Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss. | Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss.
Ueki H, Mizushina T, Laoharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachvogel B, Pöschl E, Kawaminami M., Free PMC Article | 05/25/2013 |
| Annexins and collagen X may rather fulfill functions in growth plate cartilage not directly linked to the mineralization process. | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.
Grskovic I, Kutsch A, Frie C, Groma G, Stermann J, Schlötzer-Schrehardt U, Niehoff A, Moss SE, Rosenbaum S, Pöschl E, Chmielewski M, Rappl G, Abken H, Bateman JF, Cheah KS, Paulsson M, Brachvogel B. | 03/30/2013 |
| AnV blocked phosphatidylserine, enhanced T cell mediated tumor immunity, and inhibited tumor growth. | Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo.
Yan X, Doffek K, Yin C, Krein M, Phillips M, Sugg SL, Johnson B, Shilyansky J., Free PMC Article | 02/2/2013 |
| inhibited efferocytosis with annexin V worsened elastase-induced pulmonary emphysema in mice, which was, at least partly, attributed to a lack of phenotypic change in macrophages toward anti-inflammatory one. | Annexin V decreases PS-mediated macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice.
Yoshida S, Minematsu N, Chubachi S, Nakamura H, Miyazaki M, Tsuduki K, Takahashi S, Miyasho T, Iwabuchi T, Takamiya R, Tateno H, Mouded M, Shapiro SD, Asano K, Betsuyaku T. | 01/26/2013 |
| AnxA5 participates in the membrane repair process. | Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair.
Bouter A, Gounou C, Bérat R, Tan S, Gallois B, Granier T, d'Estaintot BL, Pöschl E, Brachvogel B, Brisson AR., Free PMC Article | 07/23/2011 |