| Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are Susceptible to Obesity and Glucose Intolerance. | Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are Susceptible to Obesity and Glucose Intolerance.
Wang F, Ko CW, Qu J, Wu D, Zhu Q, Liu M, Tso P., Free PMC Article | 03/13/2024 |
| Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling. | Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.
Cheng C, Liu XH, He J, Gao J, Zhou JT, Fan JN, Jin X, Zhang J, Chang L, Xiong Z, Yu J, Li S, Li X. | 10/8/2022 |
| Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV. | Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.
Pan X, Hussain MM., Free PMC Article | 06/25/2022 |
| Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice. | Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.
Perampalam P, Hassan HM, Lilly GE, Passos DT, Torchia J, Kiser PK, Bozovic A, Kulasingam V, Dick FA., Free PMC Article | 09/25/2021 |
| Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages. | Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages.
Shimabukuro Okuda L, Tallada Iborra R, Ramos Pinto P, Fabres Machado U, Corrêa-Giannella ML, Pickford R, Woods T, Brimble MA, Rye KA, Passarelli M., Free PMC Article | 07/10/2021 |
| Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice. | Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice.
Wang Y, Yang Z, Wei Y, Li X, Li S. | 06/12/2021 |
| Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics. | Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics.
Yang N, Yu L, Deng Y, Han Q, Wang J, Yu L, Zhai Z, Li W. | 04/17/2021 |
| Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue. | Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue.
Pence S, LaRussa Z, Shen Z, Liu M, Coschigano KT, Shi H, Lo CC., Free PMC Article | 04/17/2021 |
| Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naive allergic patients and allergen-challenged mice. | Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice.
Roula D, Theiler A, Luschnig P, Sturm GJ, Tomazic PV, Marsche G, Heinemann A, Sturm EM., Free PMC Article | 01/23/2021 |
| ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice | Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.
Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T., Free PMC Article | 07/11/2020 |
| Reduced levels of endogenous SRC-1 and apoA-IV expression are responsible for the impaired E2's anorectic action in obese females. | Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.
Shen L, Liu Y, Tso P, Wang DQ, Davidson WS, Woods SC, Liu M., Free PMC Article | 02/16/2019 |
| This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with APOA4, and concordantly and specifically regulates APOA4 expression both in vitro and in vivo with the involvement of HuR. | A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, Chen Z., Free PMC Article | 06/24/2017 |
| Our findings may throw light on the function of ApoA4 in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 relative diseases. | Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes.
Zhang Y, He J, Zhao J, Xu M, Lou D, Tso P, Li Z, Li X., Free PMC Article | 06/24/2017 |
| Very Low Density Lipoprotein (VLDL) assembly and CREBH activation play key roles in the response to hepatic steatosis by up-regulating apoA-IV and promoting assembly and secretion of larger, more triglyceride - enriched VLDL particles. | Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression.
Cheng D, Xu X, Simon T, Boudyguina E, Deng Z, VerHague M, Lee AH, Shelness GS, Weinberg RB, Parks JS., Free PMC Article | 06/3/2017 |
| It was suggested that increased ileal GPR119 is a potential mechanism by which GLP-1 secretion is enhanced in apoA-IV-/- mice. | The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion.
Wang F, Yang Q, Huesman S, Xu M, Li X, Lou D, Woods SC, Marziano C, Tso P., Free PMC Article | 01/30/2016 |
| these data suggest that apoA-IV is not necessary for the metabolic improvements shown with VSG, but also suggest an interesting role for apoA-IV in regulating macronutrient preference and hepatic triglyceride levels. | Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice.
Pressler JW, Haller A, Sorrell J, Wang F, Seeley RJ, Tso P, Sandoval DA., Free PMC Article | 04/4/2015 |
| These results reveal ApoA-IV as a novel follicle-associated epithelium-specific marker especially in the upper small intestine of adult mice. | Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine.
Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. | 01/10/2015 |
| transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH | Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH.
Xu X, Park JG, So JS, Hur KY, Lee AH., Free PMC Article | 12/20/2014 |
| apoA-IV inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase and PEPCK gene expression through NR1D1. | Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.
Li X, Xu M, Wang F, Kohan AB, Haas MK, Yang Q, Lou D, Obici S, Davidson WS, Tso P., Free PMC Article | 03/29/2014 |
| Hepatic steatosis in mice induces hepatic apoA-IV expression, which in turn promotes lipoprotein particle expansion and reduces hepatic lipid burden without increasing the number of secreted atherogenic apoB-containing lipoprotein particles. | Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion.
VerHague MA, Cheng D, Weinberg RB, Shelness GS. | 12/14/2013 |
| Data indicate that plasma lipids, lipid absorption, and microsomal triglyceride transfer protein (MTP), FoxO1, and FoxA2 levels are lower at night and at mealtime in apoAIV-/- mice. | Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein.
Pan X, Munshi MK, Iqbal J, Queiroz J, Sirwi AA, Shah S, Younus A, Hussain MM., Free PMC Article | 09/28/2013 |
| a novel function of apoA-IV in the biogenesis of discrete HDL-A-IV particles with the participation of ABCA1 and LCAT | ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.
Duka A, Fotakis P, Georgiadou D, Kateifides A, Tzavlaki K, von Eckardstein L, Stratikos E, Kardassis D, Zannis VI., Free PMC Article | 06/1/2013 |
| peripheral apo AIV requires an intact CCK system and vagal afferents to activate neurons in the hindbrain to reduce food intake | Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake.
Lo CC, Langhans W, Georgievsky M, Arnold M, Caldwell JL, Cheng S, Liu M, Woods SC, Tso P., Free PMC Article | 02/2/2013 |
| results suggest that apoA-IV may provide a therapeutic target for the regulation of glucose-stimulated insulin secretion and treatment of diabetes | Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.
Wang F, Kohan AB, Kindel TL, Corbin KL, Nunemaker CS, Obici S, Woods SC, Davidson WS, Tso P., Free PMC Article | 09/1/2012 |
| Data show that ApoA4 is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs). | Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells.
Sanecka A, Ansems M, van Hout-Kuijer MA, Looman MW, Prosser AC, Welten S, Gilissen C, Sama IE, Huynen MA, Veltman JA, Jansen BJ, Eleveld-Trancikova D, Adema GJ. | 05/12/2012 |