| Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome? | Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?†.
Candelaria NR, Richards JS., | 05/1/2024 |
| NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence. | NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.
Wan R, Long S, Ma S, Yan P, Li Z, Xu K, Lian H, Li W, Duan Y, Zhu M, Wang L, Yu G., Free PMC Article | 04/5/2024 |
| hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2. | hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2.
Wu X, Gao H, Li F. | 11/15/2023 |
| Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Mullerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells. | Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells.
Mehanovic S, Pierre KJ, Viger RS, Tremblay JJ. | 10/8/2022 |
| Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1alpha Signaling in Diabetes-Induced Heart Failure Mice. | Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice.
Miao W, Chen M, Chen M, Cui C, Zhu Y, Luo X, Wu B., Free PMC Article | 09/24/2022 |
| Isoforms of the orphan nuclear receptor COUPTFII differentially modulate pancreatic cancer progression. | Isoforms of the orphan nuclear receptor COUP‑TFII differentially modulate pancreatic cancer progression.
Polvani S, Pepe S, Tempesti S, Tarocchi M, Marroncini G, Bencini L, Ceni E, Mello T, Picariello L, Simeone I, Grappone C, Dragoni G, Antonuzzo L, Giommoni E, Milani S, Galli A., Free PMC Article | 04/2/2022 |
| Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cellsdagger. | Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†.
Mehanovic S, Mendoza-Villarroel RE, de Mattos K, Talbot P, Viger RS, Tremblay JJ., Free PMC Article | 01/8/2022 |
| Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. | Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis.
Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV., Free PMC Article | 08/21/2021 |
| Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury. | Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Ishii S, Yamada M, Koibuchi N. | 01/9/2021 |
| Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2. | Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2.
Zhao G, Weiner AI, Neupauer KM, de Mello Costa MF, Palashikar G, Adams-Tzivelekidis S, Mangalmurti NS, Vaughan AE., Free PMC Article | 12/12/2020 |
| Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. | Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.
Kao CY, Xu M, Wang L, Lin SC, Lee HJ, Duraine L, Bellen HJ, Goldstein DS, Tsai SY, Tsai MJ., Free PMC Article | 09/5/2020 |
| Study shows that COUP-TFII is expressed in the subpopulation of neural crest cells (NCCs) and its derivatives, and targeted ablation of COUP-TFII in mouse NCCs results in markedly shortened and bifurcated tympanic rings, which in turn disturb the caudal direction of external acoustic meatus invagination. | COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring.
Hsu WH, Chen CM, You LR., Free PMC Article | 07/6/2019 |
| Study demonstrated mechanistically that COUP-TFII repressed myogenesis through direct transcriptional repression of genes important for myoblast fusion as well as inhibition of FAK activation. | Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.
Lee HJ, Kao CY, Lin SC, Xu M, Xie X, Tsai SY, Tsai MJ., Free PMC Article | 01/12/2019 |
| We showed that the orphan receptor COUP-TFII is an important player in hepatic neoangiogenesis. COUP-TFII expression in hepatic stellate cells (HSC) controls the crosstalk between hepatic HSC and endothelial cells coordinating vascular remodelling during liver injury. | The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells.
Ceni E, Mello T, Polvani S, Vasseur-Cognet M, Tarocchi M, Tempesti S, Cavalieri D, Beltrame L, Marroncini G, Pinzani M, Milani S, Galli A. | 03/10/2018 |
| elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. | Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.
Zhao F, Franco HL, Rodriguez KF, Brown PR, Tsai MJ, Tsai SY, Yao HH., Free PMC Article | 12/30/2017 |
| Together, these results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII. | Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.
Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y., Free PMC Article | 11/11/2017 |
| Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons | Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.
Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR., Free PMC Article | 10/7/2017 |
| A regulatory role of COUP-TFII in the development of muscular dystrophy. | COUP-TFII regulates satellite cell function and muscular dystrophy.
Xie X, Tsai SY, Tsai MJ., Free PMC Article | 09/16/2017 |
| FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation | FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells.
Lee MN, Kim JW, Oh SH, Jeong BC, Hwang YC, Koh JT., Free PMC Article | 07/22/2017 |
| results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene | MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.
Di-Luoffo M, Brousseau C, Tremblay JJ. | 12/17/2016 |
| These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch signaling target gene Hey1. | The Anti-Adipogenic Potential of COUP-TFII Is Mediated by Downregulation of the Notch Target Gene Hey1.
Scroyen I, Bauters D, Vranckx C, Lijnen HR., Free PMC Article | 07/2/2016 |
| Myocardial Nr2f2 overexpression causes heart failure. Nr2f2 represses genes critical for mitochondrial ETC enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased ROS and lower rates of oxygen consumption. | Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure.
Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SY., Free PMC Article | 04/30/2016 |
| Data show that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons. | The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.
Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, Tanaka DH, Kawauchi T, Sekine K, Kusuzawa S, Kawasaki T, Hirata T, Tabata H, Uhlén P, Nakajima K., Free PMC Article | 01/16/2016 |
| These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival. | Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
Tornari C, Towers ER, Gale JE, Dawson SJ., Free PMC Article | 11/28/2015 |
| COUP-TFII cooperates with the nuclear receptor steroidogenic factor 1 (SF1) to further enhance Insl3 promoter activity in Leydig cells. | The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.
Mendoza-Villarroel RE, Di-Luoffo M, Camiré E, Giner XC, Brousseau C, Tremblay JJ. | 10/31/2015 |