| The ST2[+] Treg/amphiregulin axis protects from immune-mediated hepatitis. | The ST2(+) Treg/amphiregulin axis protects from immune-mediated hepatitis.
Wachtendorf S, Jonin F, Ochel A, Heinrich F, Westendorf AM, Tiegs G, Neumann K., Free PMC Article | 04/8/2024 |
| Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse. | Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Park JS, Heo H, Kim MS, Lee SE, Park S, Kim KH, Kang YH, Kim JS, Sung YH, Shim WH, Kim DH, Song Y, Yoon SY., Free PMC Article | 03/12/2024 |
| Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis. | Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis.
Li N, Xia N, He J, Liu M, Gu M, Lu Y, Yang H, Hao Z, Zha L, Wang X, Wang W, Hu D, Hu J, Cheng X. | 02/21/2024 |
| Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis. | Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis.
Savage TM, Fortson KT, de Los Santos-Alexis K, Oliveras-Alsina A, Rouanne M, Rae SS, Gamarra JR, Shayya H, Kornberg A, Cavero R, Li F, Han A, Haeusler RA, Adam J, Schwabe RF, Arpaia N., | 02/21/2024 |
| Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets. | Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets.
Hsu CY, Faisal Mutee A, Porras S, Pineda I, Ahmed Mustafa M, J Saadh M, Adil M, H A Z. | 01/8/2024 |
| Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia-Reperfusion Injury via Enhancement of Amphiregulin Production. | Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia-Reperfusion Injury via Enhancement of Amphiregulin Production.
Inoue Y, Uchiyama A, Amalia SN, Ishikawa M, Kosaka K, Sekiguchi A, Ogino S, Yokoyama Y, Torii R, Hosoi M, Akai R, Iwawaki T, Morasso MI, Motegi SI., | 12/26/2023 |
| The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes. | The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes.
Raugh A, Jing Y, Bettini ML, Bettini M., Free PMC Article | 11/3/2023 |
| Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis. | Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis.
Ji M, Liu Y, Zuo Z, Xu C, Lin L, Li Y., Free PMC Article | 08/27/2022 |
| Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension. | Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension.
Florentin J, Zhao J, Tai YY, Sun W, Ohayon LL, O'Neil SP, Arunkumar A, Zhang X, Zhu J, Al Aaraj Y, Watson A, Sembrat J, Rojas M, Chan SY, Dutta P., Free PMC Article | 07/2/2022 |
| Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53. | Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Lindzen M, Ghosh S, Noronha A, Drago D, Nataraj NB, Leitner O, Carvalho S, Zmora E, Sapoznik S, Shany KB, Levanon K, Aderka D, Ramírez BS, Dahlhoff M, McNeish I, Yarden Y., Free PMC Article | 01/22/2022 |
| Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin. | Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin.
Coniglio SJ, Segall JE., Free PMC Article | 01/8/2022 |
| Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma. | Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.
Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Nguyen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M, Sasahara M., Free PMC Article | 12/11/2021 |
| In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals. | In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals.
Son SS, Hwang S, Park JH, Ko Y, Yun SI, Lee JH, Son B, Kim TR, Park HO, Lee EY., Free PMC Article | 09/18/2021 |
| Cardiac macrophages prevent sudden death during heart stress. | Cardiac macrophages prevent sudden death during heart stress.
Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I., Free PMC Article | 04/17/2021 |
| Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG. | Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.
Yaojia Cheng YX, Lu Q, Shi N, Zhou Q, Rong J, Li L, Wang L, Liu C., Free PMC Article | 12/5/2020 |
| Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage. | Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage.
Kim KM, Oh HT, Yoo GD, Hwang JH, Oh A, Hwang ES, Hong JH. | 09/26/2020 |
| Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland. | Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland.
Cai C, Geng A, Wang M, Yang L, Yu QC, Zeng YA. | 08/15/2020 |
| Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin-epidermal growth factor receptor signaling. | Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin-epidermal growth factor receptor signaling.
Scheffschick A, Kiritsi D, Magin TM. | 06/13/2020 |
| YAP1-dependent upregulation of amphiregulin transcript and protein amplifies amphiregulin signaling in a positive feedback loop. Soluble amphiregulin was required to induce sustained EGFR activation in proximal tubule cells in vitro. Soluble amphiregulin injection reversed protection from fibrosis after ischemia-reperfusion injury in ADAM17 hypomorphic mice and the corresponding protective proximal tubule cell phenotype. | Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis.
Kefaloyianni E, Keerthi Raja MR, Schumacher J, Muthu ML, Krishnadoss V, Waikar SS, Herrlich A., Free PMC Article | 06/13/2020 |
| Study showed that basophils contribute to inflammation in murine models of prurigo and atopic dermatitis via the release of Areg. Inhibition of local Areg production by repeated administration of the siRNA resulted in a partial, but significant, attenuation of skin responses. Histological findings showed ameliorated infiltration of inflammatory cells and improvement of acanthosis. | Amphiregulin from Basophils Amplifies Basophil-Mediated Chronic Skin Inflammation.
Hashimoto T, Satoh T, Karasuyama H, Yokozeki H. | 06/6/2020 |
| AREG-EGFR signaling protects from cholestatic injury and participates in physiological regulation of bile acid synthesis | The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis.
Santamaría E, Rodríguez-Ortigosa CM, Uriarte I, Latasa MU, Urtasun R, Alvarez-Sola G, Bárcena-Varela M, Colyn L, Arcelus S, Jiménez M, Deutschmann K, Peleteiro-Vigil A, Gómez-Cambronero J, Milkiewicz M, Milkiewicz P, Sangro B, Keitel V, Monte MJ, Marin JJG, Fernández-Barrena MG, Ávila MA, Berasain C. | 05/30/2020 |
| Study demonstrated that luteinizing hormone (LH) surge-induced Hdac3 downregulation in granulosa cells (GCs) is essential for oocyte maturation. Hdac3 inhibits Areg expression through H3K14 deacetylation prior to the LH surge. Conditional knockout and inhibition of Hdac3 in GCs increase Areg expression and result in LH-independent oocyte maturation in mice. | HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge.
Wang H, Cai H, Wang X, Zhang M, Liu B, Chen Z, Yang T, Fang J, Zhang Y, Liu W, Han J, Guo Q, Zhang H, Wang H, Xia G, Wang C., Free PMC Article | 04/4/2020 |
| FOSL1 is a determinant of lung cancer in vivo and regulates tumor cell proliferation and survival, largely in the context of KRAS mutations through amphiregulin and cell survival gene regulation. | FOSL1 Promotes Kras-induced Lung Cancer through Amphiregulin and Cell Survival Gene Regulation.
Elangovan IM, Vaz M, Tamatam CR, Potteti HR, Reddy NM, Reddy SP., Free PMC Article | 07/20/2019 |
| Study using murine luminal B breast cancer model, MMTV-PyMT crossed to Areg-knockout mice has revealed a previously unknown role of Areg in myoepithelial cell development and PyMT expression. Areg expression is essential for proper myoepithelial coverage of mammary ducts. Both Areg and myoepithelial cells can suppress PyMT expression. | Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth.
Mao SPH, Park M, Cabrera RM, Christin JR, Karagiannis GS, Oktay MH, Zaiss DMW, Abrams SI, Guo W, Condeelis JS, Kenny PA, Segall JE., Free PMC Article | 06/8/2019 |
| these results imply that IL-18 may participate in controlling the severity of stromal keratitis and contribute to tissue repair by converting both Treg and effector T cells into those that produce Amphiregulin. | Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.
Varanasi SK, Rajasagi NK, Jaggi U, Rouse BT., Free PMC Article | 04/13/2019 |