| De novo disruptive heterozygous MMP21 variants are potential predisposing genetic risk factors in Chinese Han heterotaxy children. | De novo disruptive heterozygous MMP21 variants are potential predisposing genetic risk factors in Chinese Han heterotaxy children.
Qin XJ, Xu MM, Ye JJ, Niu YW, Wu YR, Xu R, Li F, Fu QH, Chen S, Sun K, Xu YJ., Free PMC Article | 10/22/2022 |
| A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients. | A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients.
Rusek M, Michalska-Jakubus M, Kowal M, Bełtowski J, Krasowska D., Free PMC Article | 11/21/2020 |
| TWIST1, MMP-21, and HLAG-1 co-overexpression is associated with ESCC aggressiveness. | TWIST1, MMP-21, and HLAG-1 co-overexpression is associated with ESCC aggressiveness.
Golyan FF, Abbaszadegan MR, Forghanifard MM. | 08/29/2020 |
| MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. | Effect of matrix metalloproteinase-21 (572C/T) polymorphism on HIV-associated neurocognitive disorder.
Singh H, Samani D, Nambiar N, Ghate MV, Gangakhedkar RR. | 04/21/2018 |
| loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. | A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Perles Z, Moon S, Ta-Shma A, Yaacov B, Francescatto L, Edvardson S, Rein AJ, Elpeleg O, Katsanis N., Free PMC Article | 09/17/2016 |
| Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. | MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M, Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S, Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG, Masson C, Schoen P, Deleuze JF, Nitschké P, Lyonnet S, de Pontual L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW, Gordon CT., Free PMC Article | 03/12/2016 |
| Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. | Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.
Zhao Z, Yan L, Li S, Sun H, Zhou Y, Li X. | 05/16/2015 |
| These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM | High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.
Pu Y, Wang L, Wu H, Feng Z, Wang Y, Guo C. | 12/20/2014 |
| analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients | Increased MMP-21 expression is associated with poor overall survival of patients with gastric cancer.
Wu T, Li Y, Lu J, Qiao Q, Bao G, Wang N, He X, Du X. | 07/27/2013 |
| MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. | Identification of high-risk stage II and stage III colorectal cancer by analysis of MMP-21 expression.
Wu T, Li Y, Liu X, Lu J, He X, Wang Q, Li J, Du X. | 12/17/2011 |
| MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. | MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.
Boyd S, Virolainen S, Pärssinen J, Skoog T, van Hogerlinden M, Latonen L, Kyllönen L, Toftgard R, Saarialho-Kere U. | 05/10/2010 |
| MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes | Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.
Suomela S, Koljonen V, Skoog T, Kukko H, Böhling T, Saarialho-Kere U. | 02/8/2010 |
| MMP-21 may be an important protease in the terminal differentiation of keratinocytes | Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
Skoog T, Elomaa O, Pasonen-Seppänen SM, Forsberg S, Ahokas K, Jeskanen L, Pärssinen J, Tiala I, Rollman O, Lohi J, Saarialho-Kere U. | 01/21/2010 |
| A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. | No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
Qiu W, Zhou G, Zhai Y, Zhang X, Xie W, Zhang H, Yang H, Zhi L, Yuan X, Zhang X, He F, Qiu W, Zhou G, Zhai Y, Zhang X, Xie W, Zhang H, Yang H, Zhi L, Yuan X, Zhang X, He F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNo association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
Qiu W, Zhou G, Zhai Y, Zhang X, Xie W, Zhang H, Yang H, Zhi L, Yuan X, Zhang X, He F, Qiu W, Zhou G, Zhai Y, Zhang X, Xie W, Zhang H, Yang H, Zhi L, Yuan X, Zhang X, He F. The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer.
Shagisultanova EI, Novikova IA, Sidorenko YS, Marchenko GN, Strongin AY, Malkhosyan SR, Shagisultanova EI, Novikova IA, Sidorenko YS, Marchenko GN, Strongin AY, Malkhosyan SR. | 03/13/2008 |
| MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer | Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma.
Bister V, Skoog T, Virolainen S, Kiviluoto T, Puolakkainen P, Saarialho-Kere U. | 01/21/2010 |
| During esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns. | Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer.
Ahokas K, Karjalainen-Lindsberg ML, Sihvo E, Isaka K, Salo J, Saarialho-Kere U. | 01/21/2010 |
| results suggest that MMP-21 and MMP-26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorde | MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture.
Skoog T, Ahokas K, Orsmark C, Jeskanen L, Isaka K, Saarialho-Kere U. | 01/21/2010 |
| The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. | The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer.
Shagisultanova EI, Novikova IA, Sidorenko YS, Marchenko GN, Strongin AY, Malkhosyan SR, Shagisultanova EI, Novikova IA, Sidorenko YS, Marchenko GN, Strongin AY, Malkhosyan SR. | 01/21/2010 |