| T-Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids. | T-Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids.
Gaykema LH, van Nieuwland RY, Lievers E, Moerkerk WBJ, de Klerk JA, Dumas SJ, Kers J, Zaldumbide A, van den Berg CW, Rabelink TJ., Free PMC Article | 01/17/2024 |
| B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy. | B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy.
Zhao Y, Cao Y, Chen Y, Wu L, Hang H, Jiang C, Zhou X., Free PMC Article | 11/13/2021 |
| Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair. | Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair.
Molenaar B, Timmer LT, Droog M, Perini I, Versteeg D, Kooijman L, Monshouwer-Kloots J, de Ruiter H, Gladka MM, van Rooij E., Free PMC Article | 08/14/2021 |
| Knockout of beta-2 microglobulin reduces stem cell-induced immune rejection and enhances ischaemic hindlimb repair via exosome/miR-24/Bim pathway. | Knockout of beta-2 microglobulin reduces stem cell-induced immune rejection and enhances ischaemic hindlimb repair via exosome/miR-24/Bim pathway.
Zhang Y, Wang Y, Shao L, Pan X, Liang C, Liu B, Zhang Y, Xie W, Yan B, Liu F, Yu XY, Li Y., Free PMC Article | 05/15/2021 |
| Data show that serum beta-2 microglobulin (beta2M) level was increased in patients with hypertension and further increased in patients with chronic heart failure (HF). | Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor.
Li Y, Zhang X, Li L, Wang X, Chen Z, Wang X, Wang Y, Kang L, Ye Y, Jia J, Zhang G, Yang C, Yuan J, Zhou J, Ge J, Gong H, Zou Y. | 08/31/2019 |
| When no programmed delay interval was imposed, the beta2m-deficient mice acquired the task as fast as controls, suggesting that discrimination of left and right positions is not impaired by the total loss of hippocampal asymmetry. beta2m-deficient mice made fewer correct responses than control mice when variable delay was imposed, suggesting that the asymmetry of hippocampal circuitry plays an important role in working... | The asymmetry defect of hippocampal circuitry impairs working memory in β2-microglobulin deficient mice.
Goto K, Ito I. | 03/3/2018 |
| The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M. | Comparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation.
Pashley CL, Hewitt EW, Radford SE., Free PMC Article | 07/30/2016 |
| Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients. | Downregulation of beta-microglobulin to diminish T-lymphocyte lysis of non-syngeneic cell sources of engineered heart tissue constructs.
Karabekian Z, Idrees S, Ding H, Jamshidi A, Posnack NG, Sarvazyan N., Free PMC Article | 12/5/2015 |
| systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis | β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.
Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA., Free PMC Article | 11/7/2015 |
| Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment. | Dissociation of β2-microglobulin determines the surface quality control of major histocompatibility complex class I molecules.
Montealegre S, Venugopalan V, Fritzsche S, Kulicke C, Hein Z, Springer S. | 09/26/2015 |
| We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens. | Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus.
Singh RR, Yang JQ, Kim PJ, Halder RC., Free PMC Article | 06/6/2015 |
| The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN and gFAP expression in different sections of the brain in mice. | Proteasomes in the brain of β2-microglobulin knockout mice.
Lyupina YV, Bogatyrev ME, Orlova ASh, Marjukhnich EV, Kazansky DB, Sharova NP. | 01/10/2015 |
| MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex | The similar expression pattern of MHC class I molecules in human and mouse cerebellar cortex.
Lv D, Shi Q, Liu J, Zhang A, Miao F, He Y, Shen Y, Zhang J. | 09/13/2014 |
| Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits. | MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression.
Nelson PA, Sage JR, Wood SC, Davenport CM, Anagnostaras SG, Boulanger LM., Free PMC Article | 02/22/2014 |
| This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis | Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.
Denic A, Pirko I, Wootla B, Bieber A, Macura S, Rodriguez M., Free PMC Article | 04/27/2013 |
| Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. | Impact of beta 2-microglobulin on tapasin expression and covalent association.
Simone LC, Smith BL, Solheim JC., Free PMC Article | 04/6/2013 |
| This gene is known to be important for immune responses and may potentially regulate alcohol consumption. | Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies.
Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA., Free PMC Article | 05/19/2012 |
| Data show that NK subsets bearing Ly49s, which bind "self-MHC" were found to be the dominant subset responsible for beta2m(-/-) BMC rejection. | Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ., Free PMC Article | 04/7/2012 |
| NKT cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d | Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.
Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL., Free PMC Article | 01/21/2010 |
| results indicate that beta(2)m may be involved in proliferation of uNK cells in the metrial gland, and that beta(2)m may affect the maturation of uNK cells in the decidua basalis. | Uterine natural killer cells in perforin and beta(2)-microglobulin deficient mice.
Phichitrasilp T, Hondo E, Kusakabe K, Nakagawa Y, Ihara K, Wakitani S, Kiso Y. | 01/21/2010 |
| the mechanism by which beta(2)-microglobulin negatively regulates gammadelta T cell homeostasis remains to be determined | Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin.
French JD, Roark CL, Born WK, O'Brien RL., Free PMC Article | 01/21/2010 |
| these studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK T-cell-independent mechanism critical for survival during K. pneumoniae bacteremia. | Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia.
Cogen AL, Moore TA., Free PMC Article | 01/21/2010 |
| A natural killer T (NKT) cell subset is restricted by a beta-2 microglobulin-independent form of CD1d antigen and may induce bronchial hyperreactivity. | Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.
Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, DeKruyff RH, Umetsu DT., Free PMC Article | 01/21/2010 |
| Data show that cerebella from adult mice deficient for H2-D1 and H2-K1, and for beta2-microglobulin gene are of deficient elimination of supernumerary climbing fiber synapses on their Purkinje cells. | Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules.
Letellier M, Willson ML, Gautheron V, Mariani J, Lohof AM. | 01/21/2010 |
| beta 2m-associated effect other than FcRn prolongs the survival of both IgG and albumin | Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn- alpha-chain deficient mice.
Kim J, Bronson CL, Wani MA, Oberyszyn TM, Mohanty S, Chaudhury C, Hayton WL, Robinson JM, Anderson CL. | 01/21/2010 |