| Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions. | Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.
Ochiai K, Shima H, Tamahara T, Sugie N, Funayama R, Nakayama K, Kurosaki T, Igarashi K., Free PMC Article | 08/15/2024 |
| Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages. | Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages.
Schroeder AR, Xia X, Nguyen K, Zhu F, Geng J, Sialer DO, Hu H. | 12/6/2023 |
| Super-killer CTLs are generated by single gene deletion of Bach2. | Super-killer CTLs are generated by single gene deletion of Bach2.
Barton PR, Davenport AJ, Hukelmann J, Cantrell DA, Stinchcombe JC, Richard AC, Griffiths GM., Free PMC Article | 11/12/2022 |
| The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function. | The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
Li S, Bern MD, Miao B, Fan C, Xing X, Inoue T, Piersma SJ, Wang T, Colonna M, Kurosaki T, Yokoyama WM., Free PMC Article | 10/22/2022 |
| BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens. | BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.
Contreras A, Wiesner DL, Kingstad-Bakke B, Lee W, Svaren JP, Klein BS, Suresh M., Free PMC Article | 09/3/2022 |
| Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory. | Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory.
Hu Q, Xu T, Zhang W, Huang C. | 07/16/2022 |
| Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells. | Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells.
Li Y, Rao X, Tang P, Chen S, Guo Q, Fu G, Pan M, Liang L, Yao Y, Gao X, Zhou Y, Zhang Z, Xu X, Hu W, Gao J, Hua G., Free PMC Article | 12/4/2021 |
| Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2. | Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
Finney J, Kelsoe G., Free PMC Article | 09/11/2021 |
| BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells. | BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T., Free PMC Article | 05/1/2021 |
| BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. | BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
Grant FM, Yang J, Nasrallah R, Clarke J, Sadiyah F, Whiteside SK, Imianowski CJ, Kuo P, Vardaka P, Todorov T, Zandhuis N, Patrascan I, Tough DF, Kometani K, Eil R, Kurosaki T, Okkenhaug K, Roychoudhuri R., Free PMC Article | 03/6/2021 |
| Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity. | Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Zhang H, Hu Q, Zhang M, Yang F, Peng C, Zhang Z, Huang C., Free PMC Article | 10/24/2020 |
| The findings suggest that Bach2-deficient autoreactive B cells preferentially react at extrafollicular sites to give rise to IgG class-switched pathogenic plasma cells and that this effect requires the help of Bach2(-)Icos(hi) helper T cells. | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway.
Jang E, Kim UK, Jang K, Song YS, Cha JY, Yi H, Youn J., Free PMC Article | 06/20/2020 |
| Transcription regulator protein Bach2 prevents premature differentiation of suppressive effector Treg cells, limits IL-10 production and is required for the development of peripherally induced Treg cells in the gastrointestinal tract. Bach2 attenuates T-cell receptor (TCR) signaling-induced IRF4-dependent Treg cell differentiation. Bach2 counteracts the DNA-binding activity of IRF4 and limits chromatin accessibility. | Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A., Free PMC Article | 04/25/2020 |
| results demonstrate that Bach2 critically regulates Tfh cell differentiation and CD4(+) T cell memory. | Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4(+) T Cell Memory.
Geng J, Wei H, Shi B, Wang YH, Greer BD, Pittman M, Smith E, Thomas PG, Kutsch O, Hu H., Free PMC Article | 01/4/2020 |
| These data reveal that by replacing an activating complex of Batf and Irf-4 at the Bcl-6 promoter, Bach2 regulates the transcriptional network of Tfh cells in a different way, as in GC B cells. | Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6.
Lahmann A, Kuhrau J, Fuhrmann F, Heinrich F, Bauer L, Durek P, Mashreghi MF, Hutloff A. | 12/28/2019 |
| this study provides new insights into the role of BACH2 in CD4+ T cell activation during experimental malaria | The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS.
Edwards CL, de Oca MM, de Labastida Rivera F, Kumar R, Ng SS, Wang Y, Amante FH, Kometani K, Kurosaki T, Sidwell T, Kallies A, Engwerda CR., Free PMC Article | 10/12/2019 |
| Anemia of inflammation and myelodysplastic syndrome might involve reduced activity of Bach 1 and Bach2. | Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia.
Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, Suzuki K, Muto A, Fujiwara T, Nannya Y, Malcovati L, Cazzola M, Ogawa S, Harigae H, Igarashi K. | 04/27/2019 |
| These findings identify Bach2 as a requisite factor for sustaining high levels of BCR-induced proliferation, survival, and cell cycle progression | Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.
Miura Y, Morooka M, Sax N, Roychoudhuri R, Itoh-Nakadai A, Brydun A, Funayama R, Nakayama K, Satomi S, Matsumoto M, Igarashi K, Muto A. | 04/6/2019 |
| Bach2 interacts with Batf family transcription factors and controls Th2 cell development via binding to the regulatory regions in the Th2 cytokine, Batf and Batf3 gene loci. | Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.
Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M., Free PMC Article | 09/8/2018 |
| The study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4 T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state | Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4＋ T cells.
Jang E, Lee HR, Lee GH, Oh AR, Cha JY, Igarashi K, Youn J., Free PMC Article | 05/26/2018 |
| Results suggest that the mTOR-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement. | The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation.
Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, Koseki T, Igarashi K., Free PMC Article | 12/9/2017 |
| The Bach2-C/EBPbeta gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection. | A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors.
Itoh-Nakadai A, Matsumoto M, Kato H, Sasaki J, Uehara Y, Sato Y, Ebina-Shibuya R, Morooka M, Funayama R, Nakayama K, Ochiai K, Muto A, Igarashi K. | 12/2/2017 |
| Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells. | Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis.
Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K., Free PMC Article | 11/25/2017 |
| Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB subunit proto-oncogene protein c-rel (c-Rel) . | The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma.
Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, Bacon CM, Cockell SJ, Gewurz BE, Perkins ND., Free PMC Article | 09/16/2017 |
| In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2. | Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia.
Zhang H, Chen Z, Miranda RN, Medeiros LJ, McCarty N., Free PMC Article | 08/19/2017 |