| Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak. | Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.
Sovilj D, Kelemen CD, Dvorakova S, Zobalova R, Raabova H, Kriska J, Hermanova Z, Knotek T, Anderova M, Klener P, Filimonenko V, Neuzil J, Andera L. | 02/20/2024 |
| Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunctiondagger. | Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunction†.
Wei L, Feng Z, Dou Q, Tan L, Zhao X, Hao B. | 02/20/2024 |
| BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction. | BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction.
Qin D, Jia XF, Hanna A, Lee J, Pekson R, Elrod JW, Calvert JW, Frangogiannis NG, Kitsis RN., Free PMC Article | 12/18/2023 |
| Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia. | Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia.
Zhou J, Zhao Y, An P, Zhao H, Li X, Xiong Y., Free PMC Article | 08/14/2023 |
| Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage. | Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y. | 03/30/2023 |
| Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis. | Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M., Free PMC Article | 03/20/2023 |
| G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis. | G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis.
Liu W, Yang Y, Zeng Z, Tian Y, Wu Q, Zhou M, Fu ZF, Zhao L. | 04/16/2022 |
| Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, gammaH2AX accumulation, and Bax/Bak-dependence. | Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence.
Masteika IF, Sathya A, Homma S, Miller BM, Boyce FM, Miller JB., Free PMC Article | 04/9/2022 |
| Paradoxical implication of BAX/BAK in the persistence of tetraploid cells. | Paradoxical implication of BAX/BAK in the persistence of tetraploid cells.
Deng J, Gutiérrez LG, Stoll G, Motiño O, Martins I, Núñez L, Bravo-San Pedro JM, Humeau J, Bordenave C, Pan J, Fohrer-Ting H, Souquere S, Pierron G, Hetz C, Villalobos C, Kroemer G, Senovilla L., Free PMC Article | 02/5/2022 |
| MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure. | MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure.
Zhang B, Mao S, Liu X, Li S, Zhou H, Gu Y, Liu W, Fu L, Liao C, Wang P., Free PMC Article | 01/15/2022 |
| Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage. | Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.
Ding D, Prolla T, Someya S, Manohar S, Salvi R., Free PMC Article | 12/18/2021 |
| Structure of detergent-activated BAK dimers derived from the inert monomer. | Structure of detergent-activated BAK dimers derived from the inert monomer.
Birkinshaw RW, Iyer S, Lio D, Luo CS, Brouwer JM, Miller MS, Robin AY, Uren RT, Dewson G, Kluck RM, Colman PM, Czabotar PE. | 06/19/2021 |
| Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic beta-cells under glucolipotoxic stress. | Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress.
White SA, Zhang LS, Pasula DJ, Yang YHC, Luciani DS., Free PMC Article | 12/12/2020 |
| Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon. | Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
Lin L, Zhang M, Stoilov P, Chen L, Zheng S., Free PMC Article | 11/21/2020 |
| These results establish the ripoptosome/caspase-8 complex as a pro-inflammatory checkpoint that senses the perturbation of mitochondrial integrity. | BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V. | 12/14/2019 |
| BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1beta maturation and secretion. | The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE. | 12/14/2019 |
| the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes. | A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
Bayoumi AS, Park KM, Wang Y, Teoh JP, Aonuma T, Tang Y, Su H, Weintraub NL, Kim IM., Free PMC Article | 06/29/2019 |
| Our results show that reprogramming is enhanced in MEFs deficient in BAK and BAX, but only when MYC is part of the reprogramming cocktail. Thus, the propensity for Myc overexpression to elicit apoptosis creates a significant roadblock to reprogramming under OKSM conditions. | BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming.
Kim EJY, Anko ML, Flensberg C, Majewski IJ, Geng FS, Firas J, Huang DCS, van Delft MF, Heath JK., Free PMC Article | 01/19/2019 |
| It was shown that double knockout of Bax and Bak from proximal tubules attenuated renal tubular cell apoptosis and suppressed renal interstitial fibrosis in UUO. | Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis.
Mei S, Li L, Wei Q, Hao J, Su Y, Mei C, Dong Z., Free PMC Article | 11/17/2018 |
| Study reports the proximal alpha1-alpha2 loop as a second activation site in Bak and in mitochondrial Bax. | Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.
Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM., Free PMC Article | 09/8/2018 |
| Here the authors show that mouse embryonic fibroblasts deficient in Bax/Bak1 are resistant to the third major form of cell death associated with autophagy through a mechanism involving lysosome permeability. | Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.
Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, Molkentin JD., Free PMC Article | 07/7/2018 |
| BH3-only proteins bind inactive full-length BAK at mitochondria and then dissociate following exposure of the BAK BH3 and BH4 domains before BAK homodimerization | BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.
Li MX, Tan IKL, Ma SB, Hockings C, Kratina T, Dengler MA, Alsop AE, Kluck RM, Dewson G., Free PMC Article | 06/9/2018 |
| Resultdetermined the mouse Bak BH3-in-groove homodimers (BGH) structure, which allowed more accurate modeling within and between the BGHs. The BGHs were shown to oligomerize via the 'alpha 3/alpha 5 interface' in mitochondria. These findings suggest for a probable assembly of the Bak homodimers in the mitochondrial apoptotic pore. | Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore.
Mandal T, Shin S, Aluvila S, Chen HC, Grieve C, Choe JY, Cheng EH, Hustedt EJ, Oh KJ., Free PMC Article | 04/28/2018 |
| We propose that the GC-induced mitochondrial accumulation of Bax and the interaction between the GR and Bim, Bcl-xL and Bak could play a role in the regulation of thymocyte apoptosis. | The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells.
Prenek L, Boldizsár F, Kugyelka R, Ugor E, Berta G, Németh P, Berki T., Free PMC Article | 02/10/2018 |
| Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE. | 12/2/2017 |