| Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle. | Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle.
Han HK, Mukherjee S, Park SY, Lee JH, Lee EH, Kim S, Lee YH, Song DK, Lee S, Bae JH, Im SS., | 07/12/2024 |
| Betaine-homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling. | Betaine-homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling.
Liu C, Zhang Y, Wang Y, Wang N, Xu J, Liang X, Xiong J, Lu S, Zhou P, Liu J, Chen S. | 05/25/2023 |
| This study uncovered a novel antisense lncRNA (Bhmt-AS) that is co-expressed with Bhmt and concordantly and specifically regulates Bhmt expression both in vitro and in vivo to regulate hepatic gluconeogenesis. | Long non-coding RNA Bhmt-AS attenuates hepatic gluconeogenesis via modulation of Bhmt expression.
Shen X, Zhang Y, Zhang X, Yao Y, Zheng Y, Cui X, Liu C, Wang Q, Li JZ. | 07/18/2020 |
| BHMT plays a central role in the homeostasis of cochlear methionine metabolism and Bhmt2 up-regulation could carry out a compensatory role in cochlear protection against noise injury in the absence of BHMT | Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.
Partearroyo T, Murillo-Cuesta S, Vallecillo N, Bermúdez-Muñoz JM, Rodríguez-de la Rosa L, Mandruzzato G, Celaya AM, Zeisel SH, Pajares MA, Varela-Moreiras G, Varela-Nieto I., Free PMC Article | 06/6/2020 |
| Taurine treatment induced BHMT expression in HCU mice by 5-fold and restored maximal lowering of Hcy levels during long-term betaine treatment with a concomitant normalization of inflammatory cytokine expression and a significantly improved coagulative phenotype. | Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.
Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. | 05/16/2020 |
| Data indicate that improved Sp1 transcription factor (Sp1) and betaine homocysteine-S-methyltransferase (BHMT) expression are involved in the effects of zinc on oxidative stress. | Improved Sp1 and Betaine Homocysteine-S-Methyltransferase Expression and Homocysteine Clearance Are Involved in the Effects of Zinc on Oxidative Stress in High-Fat-Diet-Pretreated Mice.
Wu L, Zhou X, Li T, He J, Huang L, Ouyang Z, He L, Wei T, He Q. | 10/27/2018 |
| Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging volume, as well as impaired reference and short-term memories. | Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.
Prieur EAK, Pjetri E, Zeisel SH, Jadavji NM. | 07/7/2018 |
| BHMT expression is robustly regulated by taurine. | Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.
Jurkowska H, Niewiadomski J, Hirschberger LL, Roman HB, Mazor KM, Liu X, Locasale JW, Park E, Stipanuk MH., Free PMC Article | 12/17/2016 |
| It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked. | Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.
Teng YW, Cerdena I, Zeisel SH., Free PMC Article | 01/5/2013 |
| mouse blastocysts are unusual in being able to generate AdoMet not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT | Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development.
Lee MB, Kooistra M, Zhang B, Slow S, Fortier AL, Garrow TA, Lever M, Trasler JM, Baltz JM., Free PMC Article | 12/8/2012 |
| a role for BHMT in energy homeostasis. | Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue.
Teng YW, Ellis JM, Coleman RA, Zeisel SH., Free PMC Article | 07/14/2012 |
| BHMT has an important role in Hcy, choline, and one-carbon homeostasis | Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.
Teng YW, Mehedint MG, Garrow TA, Zeisel SH., Free PMC Article | 12/10/2011 |
| The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death. | Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.
Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N., Free PMC Article | 01/21/2010 |