| Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1beta. | Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
Morales-Maldonado A, Humphry M, Figg N, Clarke MC. | 03/11/2024 |
| Recombinant SARS-CoV-2 Spike Protein Stimulates Secretion of Chymase, Tryptase, and IL-1beta from Human Mast Cells, Augmented by IL-33. | Recombinant SARS-CoV-2 Spike Protein Stimulates Secretion of Chymase, Tryptase, and IL-1β from Human Mast Cells, Augmented by IL-33.
Tsilioni I, Theoharides TC., Free PMC Article | 06/13/2023 |
| Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland. | Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland.
Nishimura H, Jin D, Kinoshita I, Taniuchi M, Higashino M, Terada T, Takai S, Kawata R., Free PMC Article | 05/22/2023 |
| Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1. | Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1.
Fairhurst-Hunter Z, Walters RG, Zink A, Lin K, Guo Y, Yu C, Lv J, Li L, Freitag DF, Chen Z, Millwood IY., Free PMC Article | 12/17/2022 |
| Chymase-positive Mast cells correlate with tumor angiogenesis: first report in pancreatic cancer patients. | Chymase-positive Mast cells correlate with tumor angiogenesis: first report in pancreatic cancer patients.
Laface C, Laforgia M, Zito AF, Loisi D, Zizzo N, Tamma R, Gadaleta CD, Porcelli M, Currò G, Ammendola M, Ranieri G. | 04/2/2022 |
| Elevated salivary activity of mast cell chymase of periodontitis patients, and a new bradykinin generation cascade, mediating the cross-talks between mast cell and gingival fibroblast. | Elevated salivary activity of mast cell chymase of periodontitis patients, and a new bradykinin generation cascade, mediating the cross-talks between mast cell and gingival fibroblast.
Lu X, Liu J, Wei T, Zhou X. | 03/12/2022 |
| Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland. | Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland.
Kinoshita I, Jin D, Higashino M, Terada T, Kurisu Y, Takai S, Kawata R., Free PMC Article | 01/1/2022 |
| The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system. | The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system.
Ferrario CM, Groban L, Wang H, Cheng CP, VonCannon JL, Wright KN, Sun X, Ahmad S., Free PMC Article | 12/4/2021 |
| CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer. | CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer.
Shi S, Ye S, Mao J, Ru Y, Lu Y, Wu X, Xu M, Zhu T, Wang Y, Chen Y, Tang X, Xi Y. | 06/5/2021 |
| Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients. | Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.
Rathore APS, Senanayake M, Athapathu AS, Gunasena S, Karunaratna I, Leong WY, Lim T, Mantri CK, Wilder-Smith A, St John AL., Free PMC Article | 12/19/2020 |
| Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue. | Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.
Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM., Free PMC Article | 10/31/2020 |
| CMA1 polymorphisms may be associated with atrial fibrillation, and the rs1800875 GG genotype might be a susceptibility factor for AF in the Chinese Han population. | Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population.
Zhou D, Chen Y, Wu J, Shen J, Shang Y, Zheng L, Xie X., Free PMC Article | 06/27/2020 |
| Findings suggest that the angiotensin II (Ang II) generation from hAng-(1-12) is primarily mediated by chymase rather than carboxypeptidase A (CPA). | Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate.
Ahmad S, Wright KN, Sun X, Groban L, Ferrario CM., Free PMC Article | 06/6/2020 |
| Data show that chymase cleavage of chemerin (chem163S) to partially active chemerin (chem156F) can be found in synovial fluids where it can play a role in modulation of the inflammation in joints. | Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients.
Zhao L, Yamaguchi Y, Ge X, Robinson WH, Morser J, Leung LLK., Free PMC Article | 04/27/2019 |
| These findings reveal the critical role of hypoxia in producing local angiotensin II by a lactate-chymase-dependent mechanism and highlight the importance of local angiotensin II in regulating radioresistance of hypoxic tumor cells. | Hypoxia-induced angiotensin II by the lactate-chymase-dependent mechanism mediates radioresistance of hypoxic tumor cells.
Xie G, Liu Y, Yao Q, Zheng R, Zhang L, Lin J, Guo Z, Du S, Ren C, Yuan Q, Yuan Y., Free PMC Article | 11/3/2018 |
| expression markedly increased in the maternal vascular endothelium in subjects with preeclampsia compared with normal pregnant controls | Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia.
Gu Y, Lewis DF, Alexander JS, Wang Y. | 07/21/2018 |
| Cleavage of the alarmins by Human mast cell chymase and human neutrophil cathepsin G suggests a function in regulating excessive inflammation. | Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.
Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, Åbrink M, Hellman L. | 09/2/2017 |
| activation of endothelial CLP/chymase may directly relate to the increased inflammatory phenotypic changes in the vascular system in women with preeclampsia | Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentas.
Yang Gu, Chang Liu, Alexander JS, Groome LJ, Yuping Wang., Free PMC Article | 09/26/2016 |
| Placenta-derived chymotrypsin-like protease contributes to the altered endothelial barrier function in preeclampsia. | Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia.
Gu Y, Lewis DF, Alexander JS, Wang Y., Free PMC Article | 09/26/2016 |
| promoter single nucleotide polymorphism is not associated with Dengue Hemorrhagic Fever and Dengue Shock Syndrome in Vietnam and Philippines | Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Velasquez CV, Roman AD, Lan NT, Huy NT, Mercado ES, Espino FE, Perez ML, Huong VT, Thuy TT, Tham VD, Nga CT, Ha TT, Bilar JM, Bajaro JD, Baello BQ, Kikuchi M, Yasunami M, Morita K, Watanabe N, Karbwang J, Hirayama K. | 02/27/2016 |
| Our data demonstrated that mast cell chymase plays an important role in keloid formation through TGF-beta1/Smad signaling pathway. | Mast cell chymase in keloid induces profibrotic response via transforming growth factor-β1/Smad activation in keloid fibroblasts.
Dong X, Zhang C, Ma S, Wen H., Free PMC Article | 05/16/2015 |
| These data suggest a possible contribution of human chymase activation to LPS-induced mortality | Chymase activities and survival in endotoxin-induced human chymase transgenic mice.
Rafiq K, Fan YY, Sherajee SJ, Takahashi Y, Matsuura J, Hase N, Mori H, Nakano D, Kobara H, Hitomi H, Masaki T, Urata H, Nishiyama A., Free PMC Article | 04/25/2015 |
| we present data indicating that MC tryptase and chymase contribute to the development of OSF and malignant transformation of the overlying epithelium. | Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Yadav A, Desai RS, Bhuta BA, Singh JS, Mehta R, Nehete AP., Free PMC Article | 01/24/2015 |
| The polymorphisms and haplotypes of the CMA1 locus are associated with cardiac hypertrophy in male patients with symptomatic aortic stenosis. | Association of the common genetic polymorphisms and haplotypes of the chymase gene with left ventricular mass in male patients with symptomatic aortic stenosis.
Orlowska-Baranowska E, Gora J, Baranowski R, Stoklosa P, Gadomska vel Betka L, Pedzich-Placha E, Milkowska M, Koblowska MK, Hryniewiecki T, Gaciong Z, Placha G., Free PMC Article | 01/10/2015 |
| CMA1 gene single nucleotide polymorphisms is associated with essential hypertension. | [Association of CMA1 gene tag single nucleotide polymorphisms with essential hypertension in Yi population from Yunnan].
Wu Y, Li Q, Yang K, Xiao C. | 10/11/2014 |