| Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1[+/-] mouse model of craniosynostosis. | Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1(+/-) mouse model of craniosynostosis.
Feng S, Feng Q, Dong L, Lv Q, Mei S, Zhang Y., Free PMC Article | 02/21/2024 |
| Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition. | Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition.
Wan S, Liu X, Sun R, Liu H, Jiang J, Wu B., Free PMC Article | 02/6/2024 |
| Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases. | Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases.
Kellett KAB, Fisher K, Aldworth H, Hooper NM., Free PMC Article | 08/25/2023 |
| Long noncoding RNA Bmp1 modulates PHF6 expression by sponging miR-128-3p to protect intestinal mucosal in burned mice. | Long noncoding RNA Bmp1 modulates PHF6 expression by sponging miR-128-3p to protect intestinal mucosal in burned mice.
Zhuang M, Yan H, Li Q, Sun Y. | 08/2/2023 |
| BMP1 is not required for lung fibrosis in mice. | BMP1 is not required for lung fibrosis in mice.
Ma HY, N'Diaye EN, Caplazi P, Huang Z, Arlantico A, Jeet S, Wong A, Brightbill HD, Li Q, Wong WR, Sandoval W, Tam L, Newman R, Roose-Girma M, Ding N., Free PMC Article | 04/9/2022 |
| Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts. | Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.
N'Diaye EN, Cook R, Wang H, Wu P, LaCanna R, Wu C, Ye Z, Seshasayee D, Hazen M, Lin W, Tyagi T, Hotzel I, Tam L, Newman R, Roose-Girma M, Wolters PJ, Ding N. | 02/27/2021 |
| Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake. | Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake.
Banerjee S, Andrew RJ, Duff CJ, Fisher K, Jackson CD, Lawrence CB, Maeda N, Greenspan DS, Kellett KAB, Hooper NM., Free PMC Article | 10/31/2020 |
| Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases. | Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.
Eshed-Eisenbach Y, Devaux J, Vainshtein A, Golani O, Lee SJ, Feinberg K, Sukhanov N, Greenspan DS, Susuki K, Rasband MN, Peles E. | 09/12/2020 |
| Study show that integrin alpha9beta1 antagonizes both alpha3beta1-dependent mTLD/BMP-1 expression and basement membrane (BM) assembly/maturation. These findings indicate a complex interplay between these two integrins whereby alpha3beta1 promotes, and coordinately, alpha9beta1 inhibits mTLD/BMP-1 production and laminin-gamma2 processing to effect timely BM assembly and maturation during wound healing. | Opposing Roles of Epidermal Integrins α3β1 and α9β1 in Regulation of mTLD/BMP-1-Mediated Laminin-γ2 Processing during Wound Healing.
Longmate WM, Lyons SP, DeFreest L, Van De Water L, DiPersio CM., Free PMC Article | 03/9/2019 |
| Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes that is essential for murine skeletal development. | Glucose metabolism induced by Bmp signaling is essential for murine skeletal development.
Lee SY, Abel ED, Long F., Free PMC Article | 12/22/2018 |
| Loss of BMP1-like proteinase activity is shown to result in markedly thinned and fragile skin with unusually densely packed collagen fibrils and delayed wound healing. | BMP1-like proteinases are essential to the structure and wound healing of skin.
Muir AM, Massoudi D, Nguyen N, Keene DR, Lee SJ, Birk DE, Davidson JM, Marinkovich MP, Greenspan DS., Free PMC Article | 02/10/2018 |
| plays crucial role in maintaining extracellular matrix homeostasis essential to root formation and dentin mineralization | Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.
Wang J, Muir AM, Ren Y, Massoudi D, Greenspan DS, Feng JQ., Free PMC Article | 11/25/2017 |
| Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice. | Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice.
Miyauchi H, Ohta H, Nagaoka S, Nakaki F, Sasaki K, Hayashi K, Yabuta Y, Nakamura T, Yamamoto T, Saitou M., Free PMC Article | 11/11/2017 |
| the proteinases encoded by Bmp1 and Tll1 genes play essential roles in the development and maintenance of mouse dentin and periodontal ligaments. | Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.
Zhang H, Jani P, Liang T, Lu Y, Qin C., Free PMC Article | 04/15/2017 |
| The presented data demonstrate Bmp1/Tll1 products to be of profound importance to bone growth and modeling. | Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.
Muir AM, Ren Y, Butz DH, Davis NA, Blank RD, Birk DE, Lee SJ, Rowe D, Feng JQ, Greenspan DS., Free PMC Article | 01/17/2015 |
| Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. | Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
Kim B, Huang G, Ho WB, Greenspan DS., Free PMC Article | 10/22/2011 |
| during endochondral ossification, BMP and TGFbeta signaling can have antagonistic effects on chondrocyte proliferation and differentiation in vivo | Interaction of TGFβ and BMP signaling pathways during chondrogenesis.
Keller B, Yang T, Chen Y, Munivez E, Bertin T, Zabel B, Lee B., Free PMC Article | 08/6/2011 |
| BMP-1 protein was expressed in type I and IIa but not in IIb muscle fibers. BMP-1 mRNA levels were unaffected by either food deprivation or hindlimb suspension. | Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.
Allen DL, Greybeck BJ, Hanson AM, Cleary AS, Lindsay SF., Free PMC Article | 12/4/2010 |
| periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking. | Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.
Maruhashi T, Kii I, Saito M, Kudo A., Free PMC Article | 05/31/2010 |
| FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases. | Fibronectin binds and enhances the activity of bone morphogenetic protein 1.
Huang G, Zhang Y, Kim B, Ge G, Annis DS, Mosher DF, Greenspan DS., Free PMC Article | 01/21/2010 |
| proteolytic cleavage of the propeptide by BMP-1/TLD proteases plays a critical role in the activation of latent myostatin in vivo | Genetic analysis of the role of proteolysis in the activation of latent myostatin.
Lee SJ., Free PMC Article | 01/21/2010 |
| processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils | Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis.
Ge G, Seo NS, Liang X, Hopkins DR, Höök M, Greenspan DS. | 01/21/2010 |
| products of Bmp1 and Tll1 are responsible for in vivo cleavage of Chordin in mammals | Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.
Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS., Free PMC Article | 01/21/2010 |
| BMP signaling promotes the generation of astrocytes and mature, myelinating oligodendrocytes in vivo but does not affect oligodendrocyte precursor development, thus suggesting tight regulation of BMP signaling to ensure proper gliogenesis | BMP signaling mutant mice exhibit glial cell maturation defects.
See J, Mamontov P, Ahn K, Wine-Lee L, Crenshaw EB 3rd, Grinspan JB., Free PMC Article | 01/21/2010 |
| Bmp1 processes prl to a 17-kDa anti-angiogenic factor. | Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor.
Ge G, Fernández CA, Moses MA, Greenspan DS., Free PMC Article | 01/21/2010 |