| Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression. | Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression.
Marinho Y, Villarreal ES, Aboagye SY, Williams DL, Sun J, Silva CLM, Lutz SE, Oliveira SD., Free PMC Article | 11/3/2023 |
| Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension. | Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.
Wang L, Moonen JR, Cao A, Isobe S, Li CG, Tojais NF, Taylor S, Marciano DP, Chen PI, Gu M, Li D, Harper RL, El-Bizri N, Kim YM, Stankunas K, Rabinovitch M., Free PMC Article | 03/7/2023 |
| PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension. | PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Ali MK, Tian X, Zhao L, Schimmel K, Rhodes CJ, Wilkins MR, Nicolls MR, Spiekerkoetter EF., Free PMC Article | 02/11/2023 |
| BMPR2 Variants Underlie Nonsyndromic Oligodontia. | BMPR2 Variants Underlie Nonsyndromic Oligodontia.
Zheng J, Liu H, Yu M, Lin B, Sun K, Liu H, Feng H, Liu Y, Han D., Free PMC Article | 02/4/2023 |
| BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling. | BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling.
Aihara S, Fujimoto S, Sakaguchi R, Imai T. | 02/12/2022 |
| Gonadotrope-specific deletion of the BMP type 2 receptor does not affect reproductive physiology in micedaggerdouble dagger. | Gonadotrope-specific deletion of the BMP type 2 receptor does not affect reproductive physiology in mice†‡.
Ongaro L, Zhou X, Cui Y, Boehm U, Bernard DJ., Free PMC Article | 08/21/2021 |
| BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice. | BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice.
Qian S, Pan J, Su Y, Tang Y, Wang Y, Zou Y, Zhao Y, Ma H, Zhang Y, Liu Y, Guo L, Tang QQ., Free PMC Article | 06/12/2021 |
| An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension. | An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension.
Ryanto GRT, Ikeda K, Miyagawa K, Tu L, Guignabert C, Humbert M, Fujiyama T, Yanagisawa M, Hirata KI, Emoto N., Free PMC Article | 04/13/2021 |
| miR-494 regulates BMP signaling by directly targeting BMPR2 and RUNX2, and thus suppresses BMP2-induced osteogenetic differentiation at multiple levels. | Mir-494 inhibits osteoblast differentiation by regulating BMP signaling in simulated microgravity.
Qin W, Liu L, Wang Y, Wang Z, Yang A, Wang T. | 05/30/2020 |
| COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in pulmonary artery superoxide and its potential regulation of contractile phenotype proteins. | Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia.
Yu H, Alruwaili N, Hu B, Kelly MR, Zhang B, Sun D, Wolin MS., Free PMC Article | 04/4/2020 |
| Smooth muscle cell-endothelial cell contact is required for activation of Notch1 by BMPR2, to coordinate metabolism with chromatin remodeling of genes that enable EC regeneration, and to maintain monolayer integrity and vascular homeostasis in response to injury. | Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.
Miyagawa K, Shi M, Chen PI, Hennigs JK, Zhao Z, Wang M, Li CG, Saito T, Taylor S, Sa S, Cao A, Wang L, Snyder MP, Rabinovitch M., Free PMC Article | 11/23/2019 |
| High BMPR2 expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X syndrome. | Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.
Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A., Free PMC Article | 02/17/2018 |
| BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression | Opposing roles of TGFβ and BMP signaling in prostate cancer development.
Lu X, Jin EJ, Cheng X, Feng S, Shang X, Deng P, Jiang S, Chang Q, Rahmy S, Chaudhary S, Lu X, Zhao R, Wang YA, DePinho RA., Free PMC Article | 02/10/2018 |
| Dual luciferase report assay verified that miR-3065-5p could bind to the 3'UTR of bone morphogenetic protein receptor type II (BMPR2), which dramatically increased in the beginning of odontoblastic differentiation but decreased in the terminal differentiation stage. | miR-3065-5p regulates mouse odontoblastic differentiation partially through bone morphogenetic protein receptor type II.
Lin C, Zhang Q, Yu S, Lin Y, Li S, Liu H, Chen Z. | 01/6/2018 |
| increased BMPR2 signal transduction is linked to fragile X syndrome (FXS) and that the BMPR2-LIMK1 pathway is a putative therapeutic target in patients with FXS and possibly other forms of autism | Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A., Free PMC Article | 12/2/2017 |
| Disrupting BMPR2 impairs TGFbeta1- and BMP4-mediated elastic fiber assembly and is of pathophysiologic significance in pulmonary arterial hypertension. | Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Tojais NF, Cao A, Lai YJ, Wang L, Chen PI, Alcazar MAA, de Jesus Perez VA, Hopper RK, Rhodes CJ, Bill MA, Sakai LY, Rabinovitch M., Free PMC Article | 08/12/2017 |
| These results suggested that endogenous PTH enhanced BMPR2 expression by a cAMP/PKA/CREB pathway in osteoblasts, and increased RUNX2 expression through transduction of the BMP/pSMAD1/5/8 signaling pathway | Endogenous Parathyroid Hormone Promotes Fracture Healing by Increasing Expression of BMPR2 through cAMP/PKA/CREB Pathway in Mice.
Zhou W, Yu L, Fan J, Wan B, Jiang T, Yin J, Huang Y, Li Q, Yin G, Hu Z. | 08/5/2017 |
| Cav-1 depletion, oxidative stress-mediated reduction in BMPRII expression, and enhanced TGF-beta-driven SMAD-2/3 signaling promote pulmonary vascular remodeling in inflamed lungs. | Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.
Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD., Free PMC Article | 08/5/2017 |
| BMPR2 gene transfer reduced TGF-beta effects on Smad2, Smad1/5/8 and Erk1/2 phosphorylation in human pulmonary arterial smooth muscle cells | BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-β-mediated pulmonary cell signalling.
Feng F, Harper RL, Reynolds PN. | 12/17/2016 |
| loss in hippocampus and forebrain impacts exploratory and anxiety-related behaviors | Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration.
McBrayer ZL, Dimova J, Pisansky MT, Sun M, Beppu H, Gewirtz JC, O'Connor MB., Free PMC Article | 06/4/2016 |
| Deleting Bmpr2 in mouse skeletal progenitor cells impaired activin signaling resulting in an increased bone formation rate and high bone mass. | Loss of BMPR2 leads to high bone mass due to increased osteoblast activity.
Lowery JW, Intini G, Gamer L, Lotinun S, Salazar VS, Ote S, Cox K, Baron R, Rosen V., Free PMC Article | 04/23/2016 |
| The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2. | Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors.
Fujimoto M, Ohte S, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Suda N, Katagiri T., Free PMC Article | 03/26/2016 |
| BMPR2 has tumor suppressive functions in the stroma by regulating inflammation. | BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation.
Pickup MW, Hover LD, Polikowsky ER, Chytil A, Gorska AE, Novitskiy SV, Moses HL, Owens P., Free PMC Article | 02/20/2016 |
| Serotonin can increase ERalpha expression in human pulmonary arterial smooth muscle cells and antagonism of oestrogen receptor alpha reverses serotonin-dependent PH in the mouse and increases bone morphogenetic protein receptor type 2 expression | Oestrogen receptor alpha in pulmonary hypertension.
Wright AF, Ewart MA, Mair K, Nilsen M, Dempsie Y, Loughlin L, Maclean MR., Free PMC Article | 02/6/2016 |
| BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. | BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.
Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M., Free PMC Article | 02/6/2016 |