| Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability. | Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
Sampedro-Castañeda M, Baltussen LL, Lopes AT, Qiu Y, Sirvio L, Mihaylov SR, Claxton S, Richardson JC, Lignani G, Ultanir SK., Free PMC Article | 12/20/2023 |
| L-cysteine modulates visceral nociception mediated by the CaV2.3 R-type calcium channels. | L-cysteine modulates visceral nociception mediated by the Ca(V)2.3 R-type calcium channels.
Ghodsi SM, Walz M, Schneider T, Todorovic SM., Free PMC Article | 04/16/2022 |
| GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. | GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Bhandari P, Vandael D, Fernández-Fernández D, Fritzius T, Kleindienst D, Önal C, Montanaro J, Gassmann M, Jonas P, Kulik A, Bettler B, Shigemoto R, Koppensteiner P., Free PMC Article | 11/27/2021 |
| Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression. | Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.
Huang C, Yang X, Zeng B, Zeng L, Gong X, Zhou C, Xia J, Lian B, Qin Y, Yang L, Liu L, Xie P. | 05/16/2020 |
| Cav2.3 channels are regulators of nigral neuronal viability. Cav2.3 knockout reduced activity-associated nigral somatic Ca2+ signals and Ca2+-dependent after-hyperpolarizations, and afforded full protection from degeneration in vivo in a neurotoxin Parkinson's mouse model. Cav2.3 deficiency upregulated transcripts for NCS-1. Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3. | Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B., Free PMC Article | 03/7/2020 |
| The ex vivo neuronal setup of the isolated and superfused murine retina demonstrates a transient effect of bilirubin on neuronal signaling only when Cav2.3/R-type channels are present. Modulation of Cav2.3/R-type Ca2+ channels may contribute to the pathophysiological cascades of vasospasm or delayed cerebral ischemia. | Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Ca(v) 2.3 voltage-gated calcium channel.
Albanna W, Neumaier F, Lüke JN, Kotliar K, Conzen C, Lindauer U, Hescheler J, Clusmann H, Schneider T, Schubert GA., Free PMC Article | 12/22/2018 |
| The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR-34c-5p. | miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.
Gandla J, Lomada SK, Lu J, Kuner R, Bali KK., Free PMC Article | 05/5/2018 |
| Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2+ Channel knockout (CaV2.3-/-) mice. | Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
Wang K, Kelley MH, Wu WW, Adelman JP, Maylie J., Free PMC Article | 06/4/2016 |
| under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis. | Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion.
Drobinskaya I, Neumaier F, Pereverzev A, Hescheler J, Schneider T. | 09/5/2015 |
| Cav2.1-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo | Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.
Ricoy UM, Frerking ME., Free PMC Article | 01/31/2015 |
| Low-voltage activated CaV2.3 R-type Ca(2+) channels in the thalamocortical loop and extra-thalamocortical circuitries substantially regulate rodent sleep architecture and represent a novel potential target for pharmacological treatment of sleep disorders | The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture.
Siwek ME, Müller R, Henseler C, Broich K, Papazoglou A, Weiergräber M., Free PMC Article | 12/20/2014 |
| Cacna1e expression (and Cacna1h) is essential for paraventricular hypothalamic neuronal activity and preventing hyperphagia. | LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
Zaman T, Zhou X, Pandey NR, Qin Z, Keyhanian K, Wen K, Courtney RD, Stewart AF, Chen HH., Free PMC Article | 03/1/2014 |
| Cav2.3 does not only contribute to the cardiac autonomous nervous system but also to intrinsic rhythm propagation. | Pharmacoresistant Cav 2·3 (E-type/R-type) voltage-gated calcium channels influence heart rate dynamics and may contribute to cardiac impulse conduction.
Galetin T, Tevoufouet EE, Sandmeyer J, Matthes J, Nguemo F, Hescheler J, Weiergräber M, Schneider T. | 01/25/2014 |
| This study demonistrated that Immunogold particles were observed over the plasma membrane of dendritic spines of neurin in brain, including both synaptic and extrasynaptic sites | Quantitative regional and ultrastructural localization of the Ca(v)2.3 subunit of R-type calcium channel in mouse brain.
Parajuli LK, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y., Free PMC Article | 12/22/2012 |
| Cav2.3 voltage-gated divalent calcium channels (VGCC) are an important factor in septohippocampal synchronization associated with theta; oscillation. | Atropine-sensitive hippocampal θ oscillations are mediated by Cav2.3 R-type Ca²⁺ channels.
Müller R, Struck H, Ho MS, Brockhaus-Dumke A, Klosterkötter J, Broich K, Hescheler J, Schneider T, Weiergräber M. | 11/24/2012 |
| stimulation with exogenous PACAP and native neuronal stress stimulation both lead to a PKC-mediated phosphodependent recruitment of a T-type Ca(v)3.2 Ca(2+) influx, which in turn evokes catecholamine release during the acute sympathetic stress response | Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.
Hill J, Chan SA, Kuri B, Smith C., Free PMC Article | 02/25/2012 |
| Both high-affinity Ni(2+)-sensitive Ca(2+) channels contribute to transretinal signalling. | Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina.
Alnawaiseh M, Albanna W, Chen CC, Campbell KP, Hescheler J, Lüke M, Schneider T., Free PMC Article | 02/4/2012 |
| This study provides evidence for the first time that Ca(v)2.3 E/R-type Ca2+ channels are important in modulating thalamocortical hyperoscillation exerting anti-epileptogenic effects in non-convulsive absence seizures. | Altered thalamocortical rhythmicity in Ca(v)2.3-deficient mice.
Weiergräber M, Henry M, Ho MS, Struck H, Hescheler J, Schneider T. | 01/21/2010 |
| functional role for the Ca(v)2.3 subunit in hormone secretion and glucose homeostasis | Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels.
Pereverzev A, Mikhna M, Vajna R, Gissel C, Henry M, Weiergräber M, Hescheler J, Smyth N, Schneider T. | 01/21/2010 |
| the postsynaptic role of the R-type channel in the propagation of excitation and other mechanisms underlying the increased halothane MAC(RR) in Ca(v)2.3(-/-) mice | Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel.
Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T. | 01/21/2010 |
| Ca influx through CaV(2.3) voltage-sensitive Ca channels selectively activates SK channels, revealing the presence of functional Ca microdomains within the spine. | Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
Bloodgood BL, Sabatini BL. | 01/21/2010 |
| a specific role for Ca(V)2.3 Ca(2+) channels in second-phase insulin release, that of mediating the Ca(2+) entry needed for replenishment of the releasable pool of granules as well as islet cell differentiation | CaV2.3 calcium channels control second-phase insulin release.
Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E., Free PMC Article | 01/21/2010 |
| Cav2.3 immunoreactivity was found in the outer spiral bundle followed by the inner spiral bundle, efferent endings and by medial efferent fibers | Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti.
Waka N, Knipper M, Engel J. | 01/21/2010 |
| role in calcium currents in spermatocytes | Analysis of Ca(2+) currents in spermatocytes from mice lacking Ca(v)2.3 (alpha(1E)) Ca(2+) channel.
Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T. | 01/21/2010 |
| compensatory expression of Cav2.3 channels at neuromuscular junctions of mice with a single amino acid change in Cav2.1 | Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.
Kaja S, Van de Ven RC, Ferrari MD, Frants RR, Van den Maagdenberg AM, Plomp JJ. | 01/21/2010 |