| CaMKIIbeta deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I. | CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I.
Falcetta D, Quirim S, Cocchiararo I, Chabry F, Théodore M, Stiefvater A, Lin S, Tintignac L, Ivanek R, Kinter J, Rüegg MA, Sinnreich M, Castets P., Free PMC Article | 05/28/2024 |
| MFG-E8 facilitates heart repair through M1/M2 polarization after myocardial infarction by inhibiting CaMKII. | MFG-E8 facilitates heart repair through M1/M2 polarization after myocardial infarction by inhibiting CaMKII.
Ding P, Liu J, Meng Y, Wang H, Huang Y, Su G, Xia C, Du X, Dong N, Cui T, Zhang J, Li J. | 01/4/2024 |
| CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta. | CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.
Besio R, Contento BM, Garibaldi N, Filibian M, Sonntag S, Shmerling D, Tonelli F, Biggiogera M, Brini M, Salmaso A, Jovanovic M, Marini JC, Rossi A, Forlino A., Free PMC Article | 06/1/2023 |
| Differential roles of CaMKII isoforms in phase separation with NMDA receptors and in synaptic plasticity. | Differential roles of CaMKII isoforms in phase separation with NMDA receptors and in synaptic plasticity.
Cai Q, Chen X, Zhu S, Nicoll RA, Zhang M. | 04/7/2023 |
| CaMKII may regulate renal tubular epithelial cell apoptosis through YAP/NFAT2 in acute kidney injury mice. | CaMKII may regulate renal tubular epithelial cell apoptosis through YAP/NFAT2 in acute kidney injury mice.
Huang Z, Peng Y, Ke G, Xiao Y, Chen Y., Free PMC Article | 02/11/2023 |
| Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP. | Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP.
Franz A, Weber AI, Preußner M, Dimos N, Stumpf A, Ji Y, Moreno-Velasquez L, Voigt A, Schulz F, Neumann A, Kuropka B, Kühn R, Urlaub H, Schmitz D, Wahl MC, Heyd F., Free PMC Article | 01/14/2023 |
| GluN1 antibody causes behavioral deficits in prepulse inhibition and memory through CaMKIIbeta signaling. | GluN1 antibody causes behavioral deficits in prepulse inhibition and memory through CaMKIIβ signaling.
Luo Y, Yu Y, Zhang M, Fan N. | 12/10/2022 |
| A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIbeta Signaling in Limb Girdle Muscular Dystrophy. | A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy.
Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ., Free PMC Article | 02/26/2022 |
| Synaptic memory requires CaMKII. | Synaptic memory requires CaMKII.
Tao W, Lee J, Chen X, Díaz-Alonso J, Zhou J, Pleasure S, Nicoll RA., Free PMC Article | 02/19/2022 |
| Adeno-associated virus-mediated expression of an inactive CaMKIIbeta mutant enhances muscle mass and strength in mice. | Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice.
Eguchi T, Yamanashi Y. | 02/12/2022 |
| CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles. | CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles.
Moro A, van Woerden GM, Toonen RF, Verhage M., Free PMC Article | 09/19/2020 |
| Loss of Camk2 in a Camk2a/Camk2b double-mutant mice is lethal. | CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM., Free PMC Article | 06/20/2020 |
| Study shows that autophosphorylation of F-actin binding domain of CaMKIIbeta is required for fear learning. | Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.
Kim K, Suzuki A, Kojima H, Kawamura M, Miya K, Abe M, Yamada I, Furuse T, Wakana S, Sakimura K, Hayashi Y. | 11/30/2019 |
| Region-specific overexpression of betaCaMKII in dentate gyrus (DG) impairs behavioral flexibility, and severely attenuates the NMDAR-dependent long-term depression (LTD) in DG medial perforant path, which is further confirmed by the diminished AMPAR internalization and dephosphorylation during LTD. | Overexpression of βCaMKII impairs behavioral flexibility and NMDAR-dependent long-term depression in the dentate gyrus.
Yin P, Xu H, Wang Q, Wang J, Yin L, Xu M, Xie Z, Liu W, Cao X. | 05/12/2018 |
| data suggest that phosphorylation of CaMKIIbeta through the mGluR/IP3R1/PKC signaling pathway represses excessive spine formation and elongation in mature Purkinje cells. | Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ.
Sugawara T, Hisatsune C, Miyamoto H, Ogawa N, Mikoshiba K., Free PMC Article | 05/12/2018 |
| The molecular, temporal and region-specific requirements of the CAMK2B in mouse locomotion have been described. | The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion.
Kool MJ, van de Bree JE, Bodde HE, Elgersma Y, van Woerden GM., Free PMC Article | 04/7/2018 |
| CaMKII is a target of PTENalpha phosphatase and that PTENalpha is an essential element in the molecular regulation of neural activity. | PTENα Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning.
Wang P, Mei F, Hu J, Zhu M, Qi H, Chen X, Li R, McNutt MA, Yin Y. | 03/31/2018 |
| these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism. | Protein Kinase A Subunit Balance Regulates Lipid Metabolism in Caenorhabditis elegans and Mammalian Adipocytes.
Lee JH, Han JS, Kong J, Ji Y, Lv X, Lee J, Li P, Kim JB., Free PMC Article | 05/20/2017 |
| Study used an unbiased semiquantitative proteomics approach to identify biologically relevant phosphorylation sites on both CaMKIIa and CaMKIIb | Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain.
Baucum AJ 2nd, Shonesy BC, Rose KL, Colbran RJ., Free PMC Article | 01/16/2016 |
| VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. | Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, Rebeck GW, Hoe HS., Free PMC Article | 09/5/2015 |
| CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia. | Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia.
McCullough LD, Tarabishy S, Liu L, Benashski S, Xu Y, Ribar T, Means A, Li J., Free PMC Article | 11/23/2013 |
| Our data point toward a critical role of CaMKIIbeta in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism | CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.
Waggener CT, Dupree JL, Elgersma Y, Fuss B., Free PMC Article | 08/31/2013 |
| Data suggest that the CaMKIIdeltaB-induced imbalance between NCX1 and SERCA2 is partially responsible for the disturbance of intracellular Ca(2) homeostasis and the pathological process of heart failure. | CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart.
Lu YM, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li XM, Han F., Free PMC Article | 03/3/2012 |
| Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. | Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Jiao Y, Jalan-Sakrikar N, Robison AJ, Baucum AJ 2nd, Bass MA, Colbran RJ., Free PMC Article | 01/28/2012 |
| our data provide compelling support for a model of CaMKII function in which alphaCaMKII and betaCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning. | βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.
Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y., Free PMC Article | 09/17/2011 |