| Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype. | Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype.
Wang Y, Li M, Chen J, Yu Y, Yu Y, Shi H, Liu X, Chen Z, Chen R, Ge J. | 11/2/2023 |
| Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis. | Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis.
Zhang L, Zheng D, Yan Y, Yu Y, Chen R, Li Z, Greer PA, Peng T, Wang Q., Free PMC Article | 07/2/2022 |
| Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis. | Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis.
Huang X, Zhang KJ, Jiang JJ, Jiang SY, Lin JB, Lou YJ., Free PMC Article | 03/12/2022 |
| Capn4 aggravates angiotensin II-induced cardiac hypertrophy by activating the IGF-AKT signalling pathway. | Capn4 aggravates angiotensin II-induced cardiac hypertrophy by activating the IGF-AKT signalling pathway.
Cao Y, Wang Q, Liu C, Wang W, Lai S, Zou H, Tao E, Wang F, Wan L. | 02/12/2022 |
| Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways. | Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.
Liang L, Li H, Cao T, Qu L, Zhang L, Fan GC, Greer PA, Li J, Jones DL, Peng T., Free PMC Article | 05/8/2021 |
| deletion of Capns1 elevated the protein levels of beta-catenin in endothelial cells of Capns1-KO mice and constitutive activity of calpain 2 suppressed beta-catenin protein expression in cultured endothelial cells | Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis.
Teng X, Ji C, Zhong H, Zheng D, Ni R, Hill DJ, Xiong S, Fan GC, Greer PA, Shen Z, Peng T., Free PMC Article | 02/15/2020 |
| Mitochondrial calpain-1 disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia. | Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Ni R, Zheng D, Wang Q, Yu Y, Chen R, Sun T, Wang W, Fan GC, Greer PA, Gardiner RB, Peng T., Free PMC Article | 12/5/2015 |
| Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1. Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance. | Overview of calpain-mediated regulation of bone and fat mass in osteoblasts.
Shimada M., Free PMC Article | 12/21/2013 |
| effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB activation, resulting in inhibition of inflammatory responses. | Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.
Ma J, Wei M, Wang Q, Li J, Wang H, Liu W, Lacefield JC, Greer PA, Karmazyn M, Fan GC, Peng T., Free PMC Article | 11/17/2012 |
| Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces. | Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4.
Menon S, Kang CM, Beningo KA., Free PMC Article | 09/3/2011 |
| osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin levels and a lean phenotype under a normal chow diet. | A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.
Kashiwagi A, Fein MJ, Shimada M., Free PMC Article | 08/13/2011 |
| Calpain 4 is not necessary for LFA-1-mediated adhesion, conjugation or migration. | Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
Wernimont SA, Simonson WT, Greer PA, Seroogy CM, Huttenlocher A., Free PMC Article | 09/13/2010 |
| Data suggest that the calpain small subunit, Capn4, is essential for proper chondrocyte functions in embryonic growth plates. | Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation.
Kashiwagi A, Schipani E, Fein MJ, Greer PA, Shimada M., Free PMC Article | 06/14/2010 |
| Capn4 overexpression underlies invasion and metastasis after liver transplantation for hepatocellular carcinoma and may be a candidate biomarker for future diagnosis and a target for therapy. | Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Bai DS, Dai Z, Zhou J, Liu YK, Qiu SJ, Tan CJ, Shi YH, Huang C, Wang Z, He YF, Fan J. | 01/21/2010 |
| CAPNS1 interferes with PP2A-Akt interaction consequently affecting FoxO3A-dependent cell death. | Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.
Bertoli C, Copetti T, Lam EW, Demarchi F, Schneider C. | 01/21/2010 |
| Capn4 plays an important role in the production of mechanical forces and in mediating mechanosensing during fibroblast migration and is a regulatory subunit for calpain 1 and calpain 2 | The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.
Undyala VV, Dembo M, Cembrola K, Perrin BJ, Huttenlocher A, Elce JS, Greer PA, Wang YL, Beningo KA., Free PMC Article | 01/21/2010 |
| Capn4 in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation | In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.
Shimada M, Greer PA, McMahon AP, Bouxsein ML, Schipani E., Free PMC Article | 01/21/2010 |
| results suggest a regulatory connection between calpain and RhoGDI-1 in promoting formation of membrane blebs | Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin.
Larsen AK, Lametsch R, Elce J, Larsen JK, Thomsen B, Larsen MR, Lawson MA, Greer PA, Ertbjerg P. | 01/21/2010 |
| The molecular ordering of PARP-1, calpains, Bax, and AIF activation is established. | Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.
Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA., Free PMC Article | 01/21/2010 |
| In calpain-deficient cells, autophagy is impaired with a resulting dramatic increase in apoptotic cell death. | Calpain is required for macroautophagy in mammalian cells.
Demarchi F, Bertoli C, Copetti T, Tanida I, Brancolini C, Eskelinen EL, Schneider C., Free PMC Article | 01/21/2010 |
| calpain-mediated endoproteolytic cleavage of PrP(Sc) may be an important event in prion propagation | Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.
Yadavalli R, Guttmann RP, Seward T, Centers AP, Williamson RA, Telling GC. | 01/21/2010 |