| CAIII transgenic hearts showed significantly less decrease in cardiac function than that of wild-type control animals. | Transgenic expression of carbonic anhydrase III in cardiac muscle demonstrates a mechanism to tolerate acidosis.
Feng HZ, Jin JP., Free PMC Article | 04/11/2020 |
| these data clearly suggests that CAIII serves as an important antioxidant critical in protecting NP cells against oxidative stress-induced injury. | Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death.
Silagi ES, Batista P, Shapiro IM, Risbud MV., Free PMC Article | 10/26/2019 |
| This study illustrates that skeletal muscle cell CAR3 is critical for CHRN homeostasis in the neuromuscular junction, and its deficiency leads to accelerated degradation of CHRN (cholinergic receptor nicotinic) and development of myasthenia gravis. | Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis.
Du A, Huang S, Zhao X, Feng K, Zhang S, Huang J, Miao X, Baggi F, Ostrom RS, Zhang Y, Chen X, Xu C., Free PMC Article | 06/8/2019 |
| CAIII is highly expressed in osteocytes, is regulated by parathyroid hormone both in vitro and in vivo, and protects osteocytes from oxidative stress. | Carbonic anhydrase III protects osteocytes from oxidative stress.
Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein AI, Petty CA, Fulzele K, Mitterberger-Vogt MC, Zwerschke W, Pereira R, Wang K, Pajevic PD., Free PMC Article | 11/3/2018 |
| Our results indicate that Car3 is not required for de novo lipogenesis, and Car3 knockout mice fed high-fat diet do not have significant differences in responses to various diets to wild type mice. | Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice.
Renner SW, Walker LM, Forsberg LJ, Sexton JZ, Brenman JE., Free PMC Article | 09/9/2017 |
| The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury. | Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.
Carter WG, Vigneswara V, Newlaczyl A, Wayne D, Ahmed B, Saddington S, Brewer C, Raut N, Gerdes HK, Erdozain AM, Tooth D, Bolt EL, Osna NA, Tuma DJ, Kharbanda KK., Free PMC Article | 05/16/2015 |
| During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes. | A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Wu L, Sagong B, Choi JY, Kim UK, Bok J. | 08/10/2013 |
| We conclude that down-regulation of CAIII in preadipocytes enhances adipogenesis and that CAIII is a regulator of adipogenic differentiation which acts at the level of PPAR-gamma2 gene expression. | Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-γ2.
Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W., Free PMC Article | 05/26/2012 |
| Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland. | Carbonic anhydrases in the mouse harderian gland.
Pan PW, Waheed A, Sly WS, Parkkila S. | 02/26/2011 |
| lack of proximal tubule cLCN5 in mice and men is associated with CAIII induction, increased cell proliferation, and oxidative stress | A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.
Gailly P, Jouret F, Martin D, Debaix H, Parreira KS, Nishita T, Blanchard A, Antignac C, Willnow TE, Courtoy PJ, Scheinman SJ, Christensen EI, Devuyst O. | 01/21/2010 |
| Mice lacking carbonic anhydrase III were viable and fertile and had normal life spans. | Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span.
Kim G, Lee TH, Wetzel P, Geers C, Robinson MA, Myers TG, Owens JW, Wehr NB, Eckhaus MW, Gros G, Wynshaw-Boris A, Levine RL., Free PMC Article | 01/21/2010 |