| Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors. | Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors.
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V., Free PMC Article | 04/21/2023 |
| Mice with a mutant thyroid hormone receptor alpha1 have permanently reduced Car4 in lung and brain. These findings identify a previously unknown marker of thyroid hormone receptor alpha1 action in brain and lung. | Thyroid hormone drives the expression of mouse carbonic anhydrase Car4 in kidney, lung and brain.
Vujovic M, Dudazy-Gralla S, Hård J, Solsjö P, Warner A, Vennström B, Mittag J. | 08/13/2016 |
| two CA isoforms, CAII and CAIV, are distributed along the epididymal epithelium and appear with the onset of puberty | Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm.
Wandernoth PM, Mannowetz N, Szczyrba J, Grannemann L, Wolf A, Becker HM, Sly WS, Wennemuth G., Free PMC Article | 04/23/2016 |
| eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation | Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.
Wen T, Mingler MK, Wahl B, Khorki ME, Pabst O, Zimmermann N, Rothenberg ME., Free PMC Article | 08/23/2014 |
| membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol in neurons | GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons.
Schneider HP, Alt MD, Klier M, Spiess A, Andes FT, Waheed A, Sly WS, Becker HM, Deitmer JW., Free PMC Article | 03/23/2013 |
| Data show a 32.13% reduction in total CA activity in CA IV(-/-) mice. | Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm.
Wandernoth PM, Raubuch M, Mannowetz N, Becker HM, Deitmer JW, Sly WS, Wennemuth G., Free PMC Article | 04/30/2011 |
| Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland. | Carbonic anhydrases in the mouse harderian gland.
Pan PW, Waheed A, Sly WS, Parkkila S. | 02/26/2011 |
| Both methazolamide and dichlorphenamide increased the tetanic muscle force in the treated M. extensor digitorum longus muscle group. | Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.
Giacomotto J, Pertl C, Borrel C, Walter MC, Bulst S, Johnsen B, Baillie DL, Lochmüller H, Thirion C, Ségalat L. | 03/1/2010 |
| study demonstrated that the sour-sensing cells act as the taste sensors for carbonation, and showed that carbonic anhydrase 4, a glycosylphosphatidylinositol-anchored enzyme, functions as the principal CO2 taste sensor | The taste of carbonation.
Chandrashekar J, Yarmolinsky D, von Buchholtz L, Oka Y, Sly W, Ryba NJ, Zuker CS., Free PMC Article | 01/21/2010 |
| Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice. | Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.
Borenshtein D, Schlieper KA, Rickman BH, Chapman JM, Schweinfest CW, Fox JG, Schauer DB., Free PMC Article | 01/21/2010 |
| Both carbonic anhydrase 4 (CA4) and CA14 contribute to neuronal pH regulation by enabling the acid-loading function of anion exchanger AE3 protein. | Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
Svichar N, Waheed A, Sly WS, Hennings JC, Hübner CA, Chesler M., Free PMC Article | 01/21/2010 |
| Data show that spermatozoa pick up membrane-bound carbonic anhydrase IV during their passage through the epididymal duct. | Carbonic anhydrase in mouse testis and epididymis; transfer of isozyme IV to spermatozoa during passage.
Ekstedt E, Holm L, Ridderstråle Y. | 01/21/2010 |
| studies on hippocampal slices on these KO mice showed that either CA can mediate buffering after synaptic transmission in hippocampal slices in the absence of the other, but that eliminating both is as effective in blocking the buffering seen in WT mice | Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain.
Shah GN, Ulmasov B, Waheed A, Becker T, Makani S, Svichar N, Chesler M, Sly WS., Free PMC Article | 01/21/2010 |