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    Casp1 caspase 1 [ Mus musculus (house mouse) ]

    Gene ID: 12362, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3/Caspase-1 pathway.

    Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3/Caspase-1 pathway.
    Sun X, Lu Y, Pang Q, Luo B, Jiang Q.

    09/24/2024
    Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.

    Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.
    Hao QN, Xue XB, Zhou H, Hu ZL.

    05/31/2024
    Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.

    Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
    Román-Domínguez L, Salazar-León J, Meza-Sosa KF, Pérez-Martínez L, Pedraza-Alva G., Free PMC Article

    05/1/2024
    Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.

    Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.
    Hegde A, Ghosh S, Ananthan AS, Kataria S, Dutta A, Prabhu S, Khedkar SU, Dutta A, Jamora C., Free PMC Article

    04/10/2024
    NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.

    NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.
    He Q, Meng C, Jia M, Tan J, Huang K, Gan H, Li L, Zhao J.

    03/1/2024
    miR-96-5p alleviates cerebral ischemia-reperfusion injury in mice by inhibiting pyroptosis via downregulating caspase 1.

    miR-96-5p alleviates cerebral ischemia-reperfusion injury in mice by inhibiting pyroptosis via downregulating caspase 1.
    Jin F, Jin L, Wei B, Li X, Li R, Liu W, Guo S, Fan H, Duan C.

    02/28/2024
    Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection.

    Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection.
    Marques-da-Silva C, Schmidt-Silva C, Baptista RP, Kurup SP.,

    02/13/2024
    Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.

    Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.
    Chen L, Yu H, Li Z, Wang Y, Jin S, Yu M, Zhu L, Ding C, Wu X, Wu T, Xun C, Zhou Y, He D, Liu Y., Free PMC Article

    01/17/2024
    Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.

    Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.
    Wu Y, Huang X, Yang L, Liu Y., Free PMC Article

    11/2/2023
    CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1beta signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.

    CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.
    Qi J, Yan X, Li L, Qiu K, Huang W, Zhou Z.

    09/23/2023
    High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.

    High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.
    Thomas SM, Olive AJ., Free PMC Article

    09/7/2023
    Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.

    Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.
    Alam MA, Caocci M, Ren M, Chen Z, Liu F, Khatun MS, Kolls JK, Qin X, Burdo TH., Free PMC Article

    08/30/2023
    Yersiniabactin-Producing E. coli Induces the Pyroptosis of Intestinal Epithelial Cells via the NLRP3 Pathway and Promotes Gut Inflammation.

    Yersiniabactin-Producing E. coli Induces the Pyroptosis of Intestinal Epithelial Cells via the NLRP3 Pathway and Promotes Gut Inflammation.
    Wang H, Shan CL, Gao B, Xiao JL, Shen J, Zhao JG, Han DM, Chen BX, Wang S, Liu G, Xin AG, Lv LB, Xiao P, Gao H., Free PMC Article

    08/16/2023
    Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus.

    Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus.
    Ketelauri P, Scharov K, von Gall C, Johann S., Free PMC Article

    08/2/2023
    ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus.

    ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus.
    Li D, Bühler M, Runft S, Gerold G, Marek K, Baumgärtner W, Strowig T, Gerhauser I., Free PMC Article

    07/12/2023
    Caspase-1 affects chronic restraint stress-induced depression-like behaviors by modifying GABAergic dysfunction in the hippocampus.

    Caspase-1 affects chronic restraint stress-induced depression-like behaviors by modifying GABAergic dysfunction in the hippocampus.
    Li M, Sun X, Wang Z, Li Y., Free PMC Article

    06/30/2023
    Comment on "Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice".

    Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".
    Wang Y, Weber M, Foreman O, Remy H, Mracsko EZ, Hanson JE.

    06/7/2023
    Response to Comment on "Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice".

    Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".
    Albornoz EA, Gordon R, Kumar V, Robertson AAB, Schroder K, Woodruff TM.

    06/7/2023
    GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.

    GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
    Lin A, Guo Y, Zhang H, Lin P, Tao K, Jiang L, Xu D, Chen B.

    05/23/2023
    Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.

    Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.
    Jing M, Qiong L, Wang Z, Xiong X, Fu Y, Yan W., Free PMC Article

    04/26/2023
    Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.

    Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
    Liu M, Cao W, Qin X, Tong J, Wu X, Cheng Y.

    03/10/2023
    [Caspase-1/-11 participates in LPS-induced sepsis-associated acute kidney injury by cleaving GSDMD].

    [Caspase-1/-11 participates in LPS-induced sepsis-associated acute kidney injury by cleaving GSDMD].
    Zhai B, Ma LS, Shen RQ, Yu J, Tao YN, Xu AP, Shao DC.

    03/6/2023
    m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-kappaB pathway mediated NLRP3-ASC-Caspase1 inflammasome.

    m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.
    Chen Y, Cao P, Xiao Z, Ruan Z.

    12/17/2022
    Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice.

    Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice.
    Flores J, Fillion ML, LeBlanc AC., Free PMC Article

    10/15/2022
    Age-dependent aggregation of alpha-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation.

    Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation.
    Hu Q, Hong M, Huang M, Gong Q, Zhang X, Uversky VN, Pan-Montojo F, Huang T, Zhou H, Zhu S.

    05/28/2022
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