| Implicating the cholecystokinin B receptor in liver stem cell oncogenesis. | Implicating the cholecystokinin B receptor in liver stem cell oncogenesis.
Gay MD, Drda JC, Chen W, Huang Y, Yassin AA, Duka T, Fang H, Shivapurkar N, Smith JP., Free PMC Article | 03/1/2024 |
| CCK2-receptor deficiency impairs immune balance by influencing CD4[+] T cells development by inhibiting cortical-thymic-epithelial-cells. | CCK2-receptor deficiency impairs immune balance by influencing CD4(+) T cells development by inhibiting cortical-thymic-epithelial-cells.
Zhang D, Jia M, Wang C, Li Y, Ma C, Zhu G, Ma R, Wen D, Jia X, Xu G, Zhang X, Cong B., Free PMC Article | 01/6/2024 |
| Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs. | Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
Mihara Y, Ishimoto T, Ozasa R, Omura T, Yamato Y, Yamada T, Okamoto A, Matsuyama Y, Nakano T. | 11/30/2023 |
| Effect of GRK4 on renal gastrin receptor regulation in hypertension. | Effect of GRK4 on renal gastrin receptor regulation in hypertension.
Xia X, Zeng Y, Li Z, Luo H, Wang W, He Y, Lu B, Guo J, Chen K, Xu X. | 08/31/2023 |
| Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway. | Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
Jiang X, Liu Y, Zhang XY, Liu X, Liu X, Wu X, Jose PA, Duan S, Xu FJ, Yang Z., Free PMC Article | 07/30/2022 |
| weevaluated the chemopreventive potential of two CCK2R antagonists,JNJ-26070109 and YF476, against pancreatic cancer using the genetically engineered mice | Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.
Mohammed A, Janakiram NB, Suen C, Stratton N, Lightfoot S, Singh A, Pathuri G, Ritchie R, Madka V, Rao CV., Free PMC Article | 02/1/2020 |
| Our data suggest a progression model for BE to EAC in which CCK2R+ progenitor cells, stimulated by hypergastrinemia, proliferate to give rise to metaplasia and dysplasia. | Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
Lee Y, Urbanska AM, Hayakawa Y, Wang H, Au AS, Luna AM, Chang W, Jin G, Bhagat G, Abrams JA, Friedman RA, Varro A, Wang KK, Boyce M, Rustgi AK, Sepulveda AR, Quante M, Wang TC., Free PMC Article | 03/10/2018 |
| CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake | The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
Jiang X, Chen W, Liu X, Wang Z, Liu Y, Felder RA, Gildea JJ, Jose PA, Qin C, Yang Z., Free PMC Article | 07/30/2016 |
| findings provide novel evidence that Cnr1 contributes to cued fear expression via an interaction with the CCKB receptor. | Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
Bowers ME, Ressler KJ., Free PMC Article | 03/19/2016 |
| There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. | Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A., Free PMC Article | 01/16/2016 |
| mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion | Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.
Zhao CM, Kodama Y, Flatberg A, Beisvag V, Kulseng B, Sandvik AK, Rehfeld JF, Chen D. | 11/7/2015 |
| CCK2R labels +4 antral stem cells that can be activated and expanded by progastrin, thus identifying one hormonal trigger for gastric stem cell interconversion and a potential target for gastric cancer chemoprevention and therapy. | CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.
Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC., Free PMC Article | 05/23/2015 |
| CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling. | Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.
Mohammad S, Ozaki T, Takeuchi K, Unno K, Yamoto K, Morioka E, Takiguchi S, Ikeda M., Free PMC Article | 02/23/2013 |
| cholecystokinin receptor-2 has a role in stress-triggered fear memory and anxiety in the mouse | Bi-directional effect of cholecystokinin receptor-2 overexpression on stress-triggered fear memory and anxiety in the mouse.
Chen Q, Tang M, Mamiya T, Im HI, Xiong X, Joseph A, Tang YP., Free PMC Article | 07/9/2011 |
| shift of breakpoint on Arrhenius plot established in CCK(2) receptor-deficiency confirms that such kind of alteration in Na(+),K(+)-ATPase temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump. | Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice.
Salum T, Kõks S, Kairane C, Mahlapuu R, Zilmer M, Vasar E. | 07/12/2010 |
| Environmental enrichment has beneficial effects in neuropathic conditions and reinforce the causal link between CCK(2) receptors, mechanical sensitivity and the development of CCI-induced hypersensitivity. | Environmental enrichment reduces mechanical hypersensitivity in neuropathic mice, but fails to abolish the phenotype of CCK2 receptor deficient mice.
Abramov U, Kurrikoff K, Matsui T, Vasar E. | 02/15/2010 |
| the expressions of CCK and CCK(2)R were increased in the hypothalamus, and the density of CCK(2)R were increased in the hypothalamus and amygdala of progastrin transgenic mice vs WT mice. | Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS.
Li Q, Deng X, Singh P. | 01/21/2010 |
| The H(2) receptor and gastrin receptor do not affect emergence of spasmolytic polypeptide (SP/TFF2)-expressing metaplasia (SPEM). The absence of H(2) receptor signaling causes a delay in the maturation of chief cells from mucous neck cells. | Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.
Aikou S, Fukushima Y, Ogawa M, Nozaki K, Saito T, Matsui T, Goldenring JR, Kaminishi M, Nomura S. | 01/21/2010 |
| CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion, while the role of CCK-1R in acid secretion is less important | Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice.
Kanai S, Hosoya H, Akimoto S, Ohta M, Matsui T, Takiguchi S, Funakoshi A, Miyasaka K., Free PMC Article | 01/21/2010 |
| in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism. | Interrelationships between circulating gastrin and iron status in mice and humans.
Kovac S, Smith K, Anderson GJ, Burgess JR, Shulkes A, Baldwin GS., Free PMC Article | 01/21/2010 |
| Data show that lacking cholecystokinin B receptors, housed in standard conditions are more anxious, display stronger restraint-induced analgesia and perform worse in the water maze when compared to corresponding wild-type littermates. | Different housing conditions alter the behavioural phenotype of CCK(2) receptor-deficient mice.
Abramov U, Raud S, Innos J, Lasner H, Kurrikoff K, Türna T, Puussaar T, Okva K, Matsui T, Vasar E. | 01/21/2010 |
| Gene expression profiling indicates that elements of the immune response are not activated in Cckbr knockout mice following chronic constriction injury. | Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice.
Kõks S, Fernandes C, Kurrikoff K, Vasar E, Schalkwyk LC. | 01/21/2010 |
| Functional postsynaptic G-protein-coupled CCK B receptors are prevalent in neonatal rodent spinal cord. | Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.
Oz M, Yang KH, Shippenberg TS, Renaud LP, O'Donovan MJ. | 01/21/2010 |
| These results suggest that mice lacking the CCK2 receptor gene are less anxious than normal mice. | Reduced anxious behavior in mice lacking the CCK2 receptor gene.
Horinouchi Y, Akiyoshi J, Nagata A, Matsushita H, Tsutsumi T, Isogawa K, Noda T, Nagayama H. | 01/21/2010 |
| This study suggests that not only pain sensitivity, but also mechanical sensitivity and the development of neuropathic pain are regulated by antagonistic interactions between CCK and opioid systems. | Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.
Kurrikoff K, Kõks S, Matsui T, Bourin M, Arend A, Aunapuu M, Vasar E. | 01/21/2010 |