| CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge. | CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Sharma A, Wang J, Gandhi CR. | 09/12/2023 |
| CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans. | CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans.
Elias-Oliveira J, Prado MKB, Souza COS, Pastore MR, Ramos SG, Costa Darini AL, Gardinassi LG, Faccioli LH., Free PMC Article | 11/19/2022 |
| Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking. | Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking.
Makaremi S, Rose M, Ranjit S, Digman MA, Bowdish DME, Moran-Mirabal JM., Free PMC Article | 03/13/2021 |
| Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. | Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling.
Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC. | 09/26/2020 |
| CD14 dictates differential activation of mesenchymal stromal cells through AKT, NF-kappaB and P38 signals. | CD14 dictates differential activation of mesenchymal stromal cells through AKT, NF-κB and P38 signals.
Jiang M, Gao T, Liu Y, Cao X, Li Y, Li J, Liu Y, Piao J., Free PMC Article | 09/5/2020 |
| this study provides major insights into molecular mechanisms connecting CD14 and CD36 with differential eicosanoid metabolism and inflammation mediated by IL-1beta. | CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1β Release and Inflammation.
Zoccal KF, Gardinassi LG, Sorgi CA, Meirelles AFG, Bordon KCF, Glezer I, Cupo P, Matsuno AK, Bollela VR, Arantes EC, Guimarães FS, Faccioli LH., Free PMC Article | 07/27/2019 |
| CD14 is critical for ArtinM-induced macrophage activation, providing fundamental insight into the design of anti-infective therapies based on carbohydrate recognition | CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition.
da Silva TA, Zorzetto-Fernandes ALV, Cecílio NT, Sardinha-Silva A, Fernandes FF, Roque-Barreira MC., Free PMC Article | 06/8/2019 |
| the functional activity of TLR2, cluster of differentiation 14 (CD14), and myeloid differentiation primary response gene 88 (MyD88) molecules in the recognition of C. albicans by gingival fibroblast, was investigated. | Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88.
Pinheiro CR, Coelho AL, de Oliveira CE, Gasparoto TH, Garlet GP, Silva JS, Santos CF, Cavassani KA, Hogaboam CM, Campanelli AP., Free PMC Article | 05/4/2019 |
| CD14 plays an important role in progression of structural and functional features of osteoarthritis in the destabilization of the medial meniscus model. | Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis.
Sambamurthy N, Zhou C, Nguyen V, Smalley R, Hankenson KD, Dodge GR, Scanzello CR., Free PMC Article | 04/13/2019 |
| CD14 expression on macrophages is necessary for airway inflammation but not for viral pathogenesis in allergic hosts. | Macrophage CD14 impacts immune defenses against influenza virus in allergic hosts.
Palipane M, Snyder JD, LeMessurier KS, Schofield AK, Woolard SN, Samarasinghe AE., Free PMC Article | 03/16/2019 |
| Overall, CD14/TLR4 signalling seems to be critical for intestinal barrier function and for the crosstalk between B cells and the epithelium, underlining that CD14 serves as a protective modulator of intestinal homeostasis. | Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation.
Basic M, Buettner M, Keubler LM, Smoczek A, Bruesch I, Buchheister S, Bleich A., Free PMC Article | 11/24/2018 |
| Investigations on the variant of CD14 gene revealed negative association among ischemic stroke patients; however, a significant association was observed for hemorrhagic stroke following dominant and recessive genotypic model. | Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke.
Das S, Kaul S, Jyothy A, Munshi A. | 07/21/2018 |
| this paper shows that CD14 gene silencing alters the microRNA expression profile of RAW264.7 cells stimulated by Brucella melitensis infection | CD14 gene silencing alters the microRNA expression profile of RAW264.7 cells stimulated by Brucella melitensis infection.
Rong H, Jiao H, Hao Y, Pang F, Li G, Peng D, Li Y, Wang Y, Zhang H, Fan Q, Wang F, Chen C, Du L. | 04/14/2018 |
| Data show that multiple phagocytes are capable of hyperactivation in response to oxPAPC, with CD14 antigen acting as the earliest regulator in this process, serving to capture and transport these lipids to promote inflammatory cell fate decisions. | By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation.
Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC., Free PMC Article | 11/11/2017 |
| Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1, Cd14, and Scara1 mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 and Scara1 in macrophages. (Lpar1 = LPA receptor 1; Cd14 = monocyte differentiation antigen CD14; Scara1 = scavenger receptor class A type I) | CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation.
An D, Hao F, Zhang F, Kong W, Chun J, Xu X, Cui MZ., Free PMC Article | 09/30/2017 |
| Stimulation of murine peritoneal macrophages with LPS induces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that was abrogated when CD14 was removed from the cell surface. | Contribution of CD14 and TLR4 to changes of the PI(4,5)P2 level in LPS-stimulated cells.
Płóciennikowska A, Hromada-Judycka A, Dembińska J, Roszczenko P, Ciesielska A, Kwiatkowska K. | 09/9/2017 |
| these results indicate that CD14 is a co-receptor of TLR4 in the S100A9-induced cytokine response. | CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes.
He Z, Riva M, Björk P, Swärd K, Mörgelin M, Leanderson T, Ivars F., Free PMC Article | 07/8/2017 |
| this study shows that lipid rafts may serve as sites in which LPS receptors (CD14) are sorted for endocytosis, rather than being platforms for the assembly of TLR4-centered signaling complexes | Lipid raft-dependent endocytosis negatively regulates responsiveness of J774 macrophage-like cells to LPS by down regulating the cell surface expression of LPS receptors.
Józefowski S, Śróttek M. | 07/1/2017 |
| These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14. | Sphingomyelin synthase 2 affects CD14‑associated induction of NF‑κB by lipopolysaccharides in acute lung injury in mice.
Hu S, Ding Y, Gong J, Yan N. | 04/15/2017 |
| Results demonstrate remarkable sophistication of microglial CD14 in enabling, facilitating and moderating innate immune responses to infectious and non-infectious CNS threats of diverse kinds | CD14 is a key organizer of microglial responses to CNS infection and injury.
Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK. | 11/5/2016 |
| CD14-mediated lipid signaling induced epithelial apoptosis, whereas TLR4 antagonistically promoted cell survival and cancer development. | LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.
Kuo WT, Lee TC, Yang HY, Chen CY, Au YC, Lu YZ, Wu LL, Wei SC, Ni YH, Lin BR, Chen Y, Tsai YH, Kung JT, Sheu F, Lin LW, Yu LC., Free PMC Article | 06/28/2016 |
| fucosyllactose directly inhibits lipopolysaccharide-mediated inflammation during E. coli infection of intestinal epithelial cells through attenuation of CD14 induction. | The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation.
He Y, Liu S, Kling DE, Leone S, Lawlor NT, Huang Y, Feinberg SB, Hill DR, Newburg DS. | 04/9/2016 |
| studies revealed a novel physical association between SP-R210S, CD14, and SR-A leading to an enhanced response to LPS, and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms | SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.
Yang L, Carrillo M, Wu YM, DiAngelo SL, Silveyra P, Umstead TM, Halstead ES, Davies ML, Hu S, Floros J, McCormack FX, Christensen ND, Chroneos ZC., Free PMC Article | 02/6/2016 |
| Data indicate that Toll-like receptor 4 (TLR4) endocytosis and the TIR-domain-containing adapter-inducing IFN-beta (TRIF)-signaling pathway in macrophages during endotoxin tolerance in the absence of cluster of differentiation 14 (CD14). | CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.
Rajaiah R, Perkins DJ, Ireland DD, Vogel SN., Free PMC Article | 10/31/2015 |
| 27OHChol can prime monocytes/macrophages by up-regulation of CD14 such that LPS-mediated inflammatory reaction is accelerated, thereby contributing to aggravated development of atherosclerotic lesions. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide.
Kim SM, Kim BY, Eo SK, Kim CD, Kim K. | 09/26/2015 |