| CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice. | CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice.
Dong M, Audiger C, Adegoke A, Lebel MÈ, Valbon SF, Anderson CC, Melichar HJ, Lesage S. | 10/2/2021 |
| CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity. | CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity.
Alotaibi F, Rytelewski M, Figueredo R, Zareardalan R, Zhang M, Ferguson PJ, Maleki Vareki S, Najajreh Y, El-Hajjar M, Zheng X, Min WP, Koropatnick J. | 10/31/2020 |
| CD5 dynamically calibrates basal NF-kappaB signaling in T cells during thymic development and peripheral activation. | CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.
Matson CA, Choi S, Livak F, Zhao B, Mitra A, Love PE, Singh NJ., Free PMC Article | 08/29/2020 |
| Collectively, these data demonstrate that the specific expression of CD5 on dendritic cells inhibits the production of inflammatory cytokines and has a regulatory effect on their activity to stimulate T cells and induce immune responses. | CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.
Li H, Burgueño-Bucio E, Xu S, Das S, Olguin-Alor R, Elmets CA, Athar M, Raman C, Soldevila G, Xu H., Free PMC Article | 03/14/2020 |
| A novel role for BTK in regulating CD1d(hi)CD5(+) Breg differentiation. | BTK signaling drives CD1d(hi)CD5(+) regulatory B-cell differentiation to promote pancreatic carcinogenesis.
Das S, Bar-Sagi D., Free PMC Article | 05/25/2019 |
| Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components. | The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis.
Mourglia-Ettlin G, Miles S, Velasco-De-Andrés M, Armiger-Borràs N, Cucher M, Dematteis S, Lozano F., Free PMC Article | 01/26/2019 |
| The natural substrate for the cell surface sialidase was identified as clustered differentiation 5 (CD5) by PNA-blot analysis of anti-CD5 immunoprecipitate. | Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5.
Kijimoto-Ochiai S, Matsumoto-Mizuno T, Kamimura D, Murakami M, Kobayashi M, Matsuoka I, Ochiai H, Ishida H, Kiso M, Kamimura K, Koda T. | 11/24/2018 |
| FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation. | TLR4 supports the expansion of FasL(+)CD5(+)CD1d(hi) regulatory B cells, which decreases in contact hypersensitivity.
Wang K, Tao L, Su J, Zhang Y, Zou B, Wang Y, Zou M, Chen N, Lei L, Li X. | 09/16/2017 |
| CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals | CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.
Mier-Aguilar CA, Cashman KS, Raman C, Soldevila G., Free PMC Article | 07/8/2017 |
| the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency. | CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.
Dong B, Somani AK, Love PE, Zheng X, Chen X, Zhang J., Free PMC Article | 03/11/2017 |
| In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity. | Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.
Kamimura D, Arima Y, Tsuruoka M, Jiang JJ, Bando H, Meng J, Sabharwal L, Stofkova A, Nishikawa N, Higuchi K, Ogura H, Atsumi T, Murakami M. | 12/17/2016 |
| In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer. | CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.
Zhang C, Xin H, Zhang W, Yazaki PJ, Zhang Z, Le K, Li W, Lee H, Kwak L, Forman S, Jove R, Yu H., Free PMC Article | 10/1/2016 |
| CD5 and CD72 play a critical role in maintaining regulatory T and B cell homeostasis | Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis.
Zheng M, Xing C, Xiao H, Ma N, Wang X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R. | 05/16/2015 |
| CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR activation. | CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens.
Henderson JG, Opejin A, Jones A, Gross C, Hawiger D. | 05/16/2015 |
| Data indicate that CD5-casein kinase 2 (CK2) signaling is necessary for efficient nuclear localization of orphan nuclear receptor ROR-gammaT (RORgammat). | CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization.
McGuire DJ, Rowse AL, Li H, Peng BJ, Sestero CM, Cashman KS, De Sarno P, Raman C., Free PMC Article | 06/28/2014 |
| These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl. | The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.
Roa NS, Ordoñez-Rueda D, Chávez-Rios JR, Raman C, García-Zepeda EA, Lozano F, Soldevila G. | 09/21/2013 |
| Although the percentage of CD1d(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration | Recombinant murine calreticulin fragment 39-272 expands CD1d(hi)CD5+ IL-10-secreting B cells that modulate experimental autoimmune encephalomyelitis in C57BL/6 mice.
Hong C, Zhang T, Gao XM. | 07/13/2013 |
| Different CD5 expression levels influence the proliferation dynamics of activated naive CD4+ T cells while leaving the conversion rate of those cells into memory cells unaffected. | Dynamics of CD4(+) T cell responses against Listeria monocytogenes.
Graw F, Weber KS, Allen PM, Perelson AS., Free PMC Article | 01/26/2013 |
| Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28. | Loss of surface antigens is a conserved feature of apoptotic lymphocytes from several mammalian species.
Diaz D, Chara L, Chevarria J, Ubeda M, Muñoz L, Barcenilla H, Sánchez MA, Moreno Z, Monserrat J, Albillos A, Prieto A, Alvarez-Mon M. | 12/10/2011 |
| CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase | A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.
Bamberger M, Santos AM, Gonçalves CM, Oliveira MI, James JR, Moreira A, Lozano F, Davis SJ, Carmo AM., Free PMC Article | 10/29/2011 |
| Delayed tumor growth in CD5-deficient mice is associated with enhanced activation of tumor-infiltrating lymphocytes due to an upregulated T cell response to T cell receptor (TCR) stimulation. | Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Tabbekh M, Franciszkiewicz K, Haouas H, Lécluse Y, Benihoud K, Raman C, Mami-Chouaib F. | 09/3/2011 |
| A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells. | A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells.
Berland R, Fiering S, Wortis HH., Free PMC Article | 01/8/2011 |
| Reduced numbers of splenic FasL+ CD5+ B cells correlated with increasing arthritis severity and decreased T-cell death in a T-cell receptor transgenic mouse model of collagen-induced arthritis. | Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.
Lundy SK, Fox DA., Free PMC Article | 01/21/2010 |
| Data provide new evidence supporting a potential role of CD5 in thymocyte survival, through a mechanism that may involve the phosphorylation of Akt. | Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling.
Ordoñez-Rueda D, Lozano F, Sarukhan A, Raman C, Garcia-Zepeda EA, Soldevila G. | 01/21/2010 |
| Ly-1 antibody reactive Embryonic stem cells functions to control the stability of nucleolin protein, which in turn is essential for maintaining their self-renewal | Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells.
Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y. | 01/21/2010 |