| The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. | The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E, Mühl-Zürbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bäuerle T, Nagel L, Schett G, Bozec A, Steinkasserer A., Free PMC Article | 09/3/2022 |
| Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy. | Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy.
Yu Y, Jin QR, Mi Y, Liu JQ, Liu ZQ, Wang S, Liu ZG, Yang PC, Zheng PY., Free PMC Article | 01/22/2022 |
| Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. | Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses.
Song W, Li H, Jia B, Wang Z, Liu Q, Yang G, Li X. | 08/28/2021 |
| CD83 expression regulates antibody production in response to influenza A virus infection. | CD83 expression regulates antibody production in response to influenza A virus infection.
Akauliya M, Gautam A, Maharjan S, Park BK, Kim J, Kwon HJ., Free PMC Article | 08/21/2021 |
| Endogenous CD83 Expression in CD4(+) Conventional T Cells Controls Inflammatory Immune Responses. | Endogenous CD83 Expression in CD4(+) Conventional T Cells Controls Inflammatory Immune Responses.
Liedtke K, Alter C, Günther A, Hövelmeyer N, Klopfleisch R, Naumann R, Wunderlich FT, Buer J, Westendorf AM, Hansen W. | 02/13/2021 |
| CD83 orchestrates immunity toward self and non-self in dendritic cells. | CD83 orchestrates immunity toward self and non-self in dendritic cells.
Wild AB, Krzyzak L, Peckert K, Stich L, Kuhnt C, Butterhof A, Seitz C, Mattner J, Grüner N, Gänsbauer M, Purtak M, Soulat D, Winkler TH, Nitschke L, Zinser E, Steinkasserer A., Free PMC Article | 10/24/2020 |
| of arthritis was associated with increased numbers of regulatory T cells, which are induced in a sCD83-IDO-TGF-beta dependent manner. Taken together, sCD83 represents an interesting approach for downregulating cytokine production, inducing regulatory T cells and inducing resolution of autoimmune arthritis. | Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.
Royzman D, Andreev D, Stich L, Rauh M, Bäuerle T, Ellmann S, Boon L, Kindermann M, Peckert K, Bozec A, Schett G, Steinkasserer A, Zinser E., Free PMC Article | 06/13/2020 |
| Study presents for the first-time data suggesting that Treg-intrinsic expression of CD83 is essential for Treg differentiation upon activation. Interestingly, mice with Treg-intrinsic CD83 deficiency are characterized by a proinflammatory phenotype. Furthermore, the loss of CD83 expression by Tregs leads to the downregulation of Treg-specific differentiation markers and the induction of an inflammatory profile. | CD83 expression is essential for Treg cell differentiation and stability.
Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M., Free PMC Article | 11/2/2019 |
| CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection. | Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.
von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L., Free PMC Article | 08/12/2017 |
| orchestrated regulation of MHC II surface expression in thymic epithelial cells (TECs) by MARCH 8 and CD83 plays a major role in CD4(+) T cell selection. | Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.
Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta NL, Gray DH, Villadangos JA, Mintern JD., Free PMC Article | 08/12/2017 |
| results show that CD83 is important for B cell activation and modulates germinal center composition and IgE Ab responses in vivo | CD83 Modulates B Cell Activation and Germinal Center Responses.
Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L. | 07/29/2017 |
| Our findings indicate that CD83 homotypic interactions regulate DC activation and promote mucosal homeostasis. | Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis.
Bates JM, Flanagan K, Mo L, Ota N, Ding J, Ho S, Liu S, Roose-Girma M, Warming S, Diehl L., Free PMC Article | 10/31/2015 |
| CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. | Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.
Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, Tucher C, Knippertz I, Becker C, Günther C, Steinkasserer A, Lechmann M. | 08/8/2015 |
| CD83 differentially modulates follicular and marginal zone B cell responses | Differential regulation of marginal zone and follicular B cell responses by CD83.
Uhde M, Kuehl S, Richardt U, Fleischer B, Osterloh A. | 06/28/2014 |
| Dendritic cells co-cultivated with antigen-specific induced Tregs expressed lower levels of CD83. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 on MARCH1 & CD83 expression. | Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Chattopadhyay G, Shevach EM., Free PMC Article | 02/22/2014 |
| activated T cells induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells. | Activated T cells induce rapid CD83 expression on B cells by engagement of CD40.
Kretschmer B, Kühl S, Fleischer B, Breloer M. | 07/16/2011 |
| found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1 | CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
Tze LE, Horikawa K, Domaschenz H, Howard DR, Roots CM, Rigby RJ, Way DA, Ohmura-Hoshino M, Ishido S, Andoniou CE, Degli-Esposti MA, Goodnow CC., Free PMC Article | 02/26/2011 |
| Data strongly suggest that CD83 is expressed by B cells upon activation and contributes to the regulation of B cell function. | CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
Kretschmer B, Lüthje K, Guse AH, Ehrlich S, Koch-Nolte F, Haag F, Fleischer B, Breloer M., Free PMC Article | 03/15/2010 |
| Cd36, Cd44 and Cd83 might play a role in specific neural circuits and present functions other than those attributed to leukocyte biology and these surface proteins, or their associated mRNA, could be used to label neurons in specific circuits/regions | Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits.
Glezer I, Bittencourt JC, Rivest S. | 02/1/2010 |
| CD83 serves as a substrate of gene related to anergy in lymphocytes (GRAIL) protein and plays a role in CD4 T cell activation. | The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells.
Su LL, Iwai H, Lin JT, Fathman CG., Free PMC Article | 01/21/2010 |
| CD83 expression levels did not significantly affect the capacity of the APC to activate CD8(+) or T cellsCD4(+) T cell activation | CD83 on murine APC does not function as a costimulatory receptor for T cells.
Kretschmer B, Lüthje K, Ehrlich S, Osterloh A, Piedavent M, Fleischer B, Breloer M. | 01/21/2010 |
| provide much needed clarification of the true nature of CD83 promoter activity | The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo.
Lechmann M, Shuman N, Wakeham A, Mak TW., Free PMC Article | 01/21/2010 |
| CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells in vivo. | CD83 expression in CD4+ T cells modulates inflammation and autoimmunity.
Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J, Hansen W. | 01/21/2010 |
| These studies further emphasize a role for CD83 in lymphocyte development and immune regulation and reveal an unexpected role for CD83 expression in influencing cell-surface MHC class II turnover. | CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
Kuwano Y, Prazma CM, Yazawa N, Watanabe R, Ishiura N, Kumanogoh A, Okochi H, Tamaki K, Fujimoto M, Tedder TF. | 01/21/2010 |
| CD83 is a functionally significant and sensitive marker of early lymphocyte activation in vivo | CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo.
Prazma CM, Yazawa N, Fujimoto Y, Fujimoto M, Tedder TF. | 01/21/2010 |