| Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity. | Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity.
Grahammer F, Dumoulin B, Gulieva RE, Wu H, Xu Y, Sulaimanov N, Arnold F, Sandner L, Cordts T, Todkar A, Moulin P, Reichardt W, Puelles VG, Kramann R, Freedman BS, Busch H, Boerries M, Walz G, Huber TB. | 10/21/2024 |
| CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis. | CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
Nayyar N, de Sauvage MA, Chuprin J, Sullivan EM, Singh M, Torrini C, Zhang BS, Bandyopadhyay S, Daniels KA, Alvarez-Breckenridge C, Dahal A, Brehm MA, Brastianos PK., Free PMC Article | 01/26/2024 |
| Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation. | Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J, Zhao L, Ruppert C, Weiss A, Schermuly RT, Eaton P, Rudyk O., Free PMC Article | 12/22/2023 |
| Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors. | Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
Pedraza N, Monserrat MV, Ferrezuelo F, Torres-Rosell J, Colomina N, Miguez-Cabello F, Párraga JP, Soto D, López-Merino E, García-Vilela C, Esteban JA, Egea J, Garí E., Free PMC Article | 11/1/2023 |
| CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue. | CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
Portales AE, Miguel I, Rodriguez MJ, Novaro V, Gambaro SE, Giovambattista A. | 04/26/2023 |
| Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling. | Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
Lee HJ, Hoe HS. | 04/10/2023 |
| Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle. | Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle.
Kim SH, Rodriguez LRL, Macias E, Rodriguez-Puebla ML., Free PMC Article | 04/30/2022 |
| Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer. | Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.
Padhye A, Konen JM, Rodriguez BL, Fradette JJ, Ochieng JK, Diao L, Wang J, Lu W, Solis LS, Batra H, Raso MG, Peoples MD, Minelli R, Carugo A, Bristow CA, Gibbons DL., Free PMC Article | 03/26/2022 |
| RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. | RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.
Pesch AM, Hirsh NH, Michmerhuizen AR, Jungles KM, Wilder-Romans K, Chandler BC, Liu M, Lerner LM, Nino CA, Ward C, Cobain EF, Lawrence TS, Pierce LJ, Rae JM, Speers CW., Free PMC Article | 03/26/2022 |
| P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway. | P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.
Shi J, Sun J, Liu L, Shan T, Meng H, Yang T, Wang S, Wei T, Chen B, Ma Y, Wang Q, Wang H, Liu J, Wang L. | 03/19/2022 |
| Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. | Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.
Tone Y, Mamchaoui K, Tsoumpra MK, Hashimoto Y, Terada R, Maruyama R, Gait MJ, Arzumanov AA, McClorey G, Imamura M, Takeda S, Yokota T, Wood MJA, Mouly V, Aoki Y., Free PMC Article | 11/27/2021 |
| Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system. | Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.
Maurer B, Brandstoetter T, Kollmann S, Sexl V, Prchal-Murphy M., Free PMC Article | 10/30/2021 |
| Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression. | Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression.
Dong F, Meng TG, Li J, Wang F, Li YY, Ouyang YC, Hou Y, Wang ZB, Schatten H, Sun QY. | 10/2/2021 |
| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. | The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D., Free PMC Article | 02/20/2021 |
| CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice. | CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice.
Costa-Guda J, Corrado K, Bellizzi J, Romano R, Saria E, Saucier K, Rose M, Shah S, Alander C, Mallya S, Arnold A., Free PMC Article | 02/6/2021 |
| Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas. | Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas.
Esteban-Burgos L, Wang H, Nieto P, Zheng J, Blanco-Aparicio C, Varela C, Gómez-López G, Fernández-García F, Sanclemente M, Guerra C, Drosten M, Galán J, Caleiras E, Martínez-Torrecuadrada J, Fajas L, Peng SB, Santamaría D, Musteanu M, Barbacid M., Free PMC Article | 12/19/2020 |
| Fkbp5 sequesters Cdk4 within the Hsp90 storage complex and prevents the formation of the cyclin D1-Cdk4 complex, which is a major inhibitor of differentiation. | Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.
Ruiz-Estevez M, Staats J, Paatela E, Munson D, Katoku-Kikyo N, Yuan C, Asakura Y, Hostager R, Kobayashi H, Asakura A, Kikyo N., Free PMC Article | 12/14/2019 |
| The authors' findings establish a firm molecular link of multiaggressiveness among SCP3, NANOG, cyclin D1, and CDK4/6 and identify CDK4/6 inhibitors as actionable drugs for controlling SCP3(high) immune-refractory cancer. These findings reveal cyclin D1-CDK4/6 inhibition as an effective strategy for controlling SCP3high immune-refractroy cancer. | Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.
Oh SJ, Cho H, Kim S, Noh KH, Song KH, Lee HJ, Woo SR, Kim S, Choi CH, Chung JY, Hewitt SM, Kim JH, Baek S, Lee KM, Yee C, Park HC, Kim TW., Free PMC Article | 06/15/2019 |
| DNA Damage Response in Proliferating Muller Glia in the Mammalian Retina. | DNA Damage Response in Proliferating Müller Glia in the Mammalian Retina.
Nomura-Komoike K, Saitoh F, Komoike Y, Fujieda H. | 04/23/2019 |
| CDK4/CDK6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. | CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.
Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, Qin B, Li Y, Wu C, Ren T, Han Y, Yin P, Kim J, Lee S, Lin J, Zhang L, Zhang J, Nowsheen S, Wang L, Boughey J, Goetz MP, Yuan J, Lou Z., Free PMC Article | 11/17/2018 |
| Study examined proliferation rates of cortical progenitor cells in mice lacking individual cdk proteins or combinations thereof. Results provide evidence that concomitant loss of cdk4 and cdk6 leads to reduced proliferation rates specifically in basal progenitor cells in both the dorsal and ventral forebrain. Cdk4-/-;Cdk6-/- double mutant progenitor cells in the dorsal telencephalon exhibit accelerated cell cycle exit. | Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain.
Grison A, Gaiser C, Bieder A, Baranek C, Atanasoski S. | 11/10/2018 |
| These results indicate that p18 blocks reprogramming by targeting Cdk4/6-mediated cell cycle regulation. | p18 inhibits reprogramming through inactivation of Cdk4/6.
Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T., Free PMC Article | 04/28/2018 |
| Activation of cdk4 triggers NAFLD. | Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.
Jin J, Valanejad L, Nguyen TP, Lewis K, Wright M, Cast A, Stock L, Timchenko L, Timchenko NA., Free PMC Article | 11/26/2017 |
| This novel mechanism explains how CDK4 promotes anabolism by blocking catabolic processes (FAO) that are activated by AMPK. | CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L. | 10/28/2017 |
| PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration. | Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice.
Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J., Free PMC Article | 09/2/2017 |