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    Cdk5r2 cyclin dependent kinase 5, regulatory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 12570, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    p39 Affects Myelin Formation in Cerebral Ischemic Injury.

    p39 Affects Myelin Formation in Cerebral Ischemic Injury.
    Meng D, Wu D, Li X, Miao Z.

    06/10/2024
    Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice.

    Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice.
    Takahashi M, Takasugi T, Kawakami A, Wei R, Ando K, Ohshima T, Hisanaga SI.

    09/24/2022
    p39-associated Cdk5 activity regulates dendritic morphogenesis.

    p39-associated Cdk5 activity regulates dendritic morphogenesis.
    Ouyang L, Chen Y, Wang Y, Chen Y, Fu AKY, Fu WY, Ip NY., Free PMC Article

    03/6/2021
    that the knockout of p39 in mice did not affect orofacial and peripheral nociception

    Peripheral and orofacial pain sensation is unaffected by the loss of p39.
    Prochazkova M, Hall B, Hu M, Okine T, Reukauf J, Binukumar BK, Amin ND, Roque E, Pant HC, Kulkarni A., Free PMC Article

    09/8/2018
    In this study, we discovered that selective upregulation of p39 is the underlying mechanism that accommodates the increased functional requirement of Cdk5 activation during neuronal differentiation. In addition, we demonstrated that p39 selectively directs Cdk5 to phosphorylate protein substrates essential for axonal development, dendritic spine formation, and synaptogenesis. Moreover, our studies suggest opposing roles o

    p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.
    Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y., Free PMC Article

    07/22/2017
    These data suggest p35 and p39 have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 activation.

    The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.
    Luo F, Zhang J, Burke K, Miller RH, Yang Y., Free PMC Article

    07/30/2016
    it was found that Tyr-15 phosphorylation occurred only on monomeric Cdk5, and the coexpression of activators, p35/p25, p39, or Cyclin I, inhibited the phosphorylation.

    Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.
    Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S., Free PMC Article

    10/4/2014
    Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.

    Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.
    Saito T, Yano M, Kawai Y, Asada A, Wada M, Doi H, Hisanaga SI., Free PMC Article

    01/25/2014
    Data indicate that p39 is selectively up-regulated in oligodendroglia (OL) during differentiation along with elevated Cdk5 activity.

    p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.
    Bankston AN, Li W, Zhang H, Ku L, Liu G, Papa F, Zhao L, Bibb JA, Cambi F, Tiwari-Woodruff SK, Feng Y., Free PMC Article

    09/7/2013
    A set of REST target genes, including Cdk5r2, is important for beta cell survival.

    Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.
    Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, Meda P, Haefliger JA., Free PMC Article

    03/2/2013
    The differential nuclear accumulation of p39 and p35 suggests their segregated functions, p35-Cdk5 in the cytoplasm and p39-Cdk5 in the nucleus.

    Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.
    Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S.

    01/21/2010
    Data show that both p35 and p39 are expressed in insulin-secreting beta cells, where they exhibit individual subcellular distributions and associate with membranous organelles of different densities.

    Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.
    Lilja L, Johansson JU, Gromada J, Mandic SA, Fried G, Berggren PO, Bark C.

    01/21/2010
    The alternating p39 parasagittal band pattern may reflect a role for p39 or Cdk5/p39 in the functional compartmentation of the cerebellum.

    The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum.
    Jeong YG, Rosales JL, Marzban H, Sillitoe RV, Park DG, Hawkes R, Lee KY.

    01/21/2010
    These findings demonstrate that Cdk5, p35, and p39 are endogenously expressed in NG108-15 cells, exhibit distinct subcellular localizations, and that both Cdk5/p35 and Cdk5/p39 are central in formation of functional synapses.

    Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.
    Johansson JU, Lilja L, Chen XL, Higashida H, Meister B, Noda M, Zhong ZG, Yokoyama S, Berggren PO, Bark C.

    01/21/2010
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