| p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor. | p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor.
Han X, Kuang Y, Chen H, Liu T, Zhang J, Liu J. | 02/6/2021 |
| The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b), p16(INK4a), and p19(ARF)) was decreased in E6AP(-/-) embryo fibroblasts. | Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y. | 11/11/2017 |
| TWIST1-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 with regard to senescence inhibition over the time course of breast tumorigenesis. | p53 and p16(Ink4a)/p19(Arf) Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor Cells.
Azzopardi S, Pang S, Klimstra DS, Du YN., Free PMC Article | 05/6/2017 |
| Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d. | Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
Ma Q, Grati M, Bai F, Pei J, Pei XH, Liu X., Free PMC Article | 11/19/2016 |
| p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging | p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.
Hilpert M, Legrand C, Bluteau D, Balayn N, Betems A, Bluteau O, Villeval JL, Louache F, Gonin P, Debili N, Plo I, Vainchenker W, Gilles L, Raslova H., Free PMC Article | 11/21/2015 |
| Cdk4 and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4. | Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M. | 03/7/2015 |
| Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase CDK inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues. | p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation.
Bai F, Chan HL, Smith MD, Kiyokawa H, Pei XH., Free PMC Article | 10/4/2014 |
| We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction | p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation.
Sonzogni SV, Ogara MF, Belluscio LM, Castillo DS, Scassa ME, Cánepa ET. | 08/23/2014 |
| CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions. | CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
Ogara MF, Belluscio LM, de la Fuente V, Berardino BG, Sonzogni SV, Byk L, Marazita M, Cánepa ET. | 07/5/2014 |
| an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos. | Differential expression of Axin1, Cdc25c and Cdkn2d mRNA in 2-cell stage mouse blastomeres.
Sun JH, Zhang Y, Yin BY, Li JX, Liu GS, Xu W, Tang S. | 06/29/2013 |
| Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner. | RUVBL2 is a novel repressor of ARF transcription.
Xie C, Wang W, Yang F, Wu M, Mei Y. | 04/14/2012 |
| DeltaNp63alpha has oncogenic activity and its overexpression in human squamous cell carcinomas contributes to the malignant phenotype, and implicate its ability to regulate p16(ink4a)/p19(arf) in the process. | Dysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytes.
Ha L, Ponnamperuma RM, Jay S, Ricci MS, Weinberg WC., Free PMC Article | 11/26/2011 |
| A significant proportion of immortalised cell cultures apparently had neither a p53 mutation nor loss of p19/ARF. | How to become immortal: let MEFs count the ways.
Odell A, Askham J, Whibley C, Hollstein M., Free PMC Article | 11/27/2010 |
| p18Ink4c and p19Ink4d protein levels are not only differentially regulated by the ubiquitin-proteasome pathway, but are subject to completely opposite modes of regulation when associated with their target Cdks. | Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d.
Forget A, Ayrault O, den Besten W, Kuo ML, Sherr CJ, Roussel MF., Free PMC Article | 01/21/2010 |
| p19(INK4D) knockdown led to a moderate increase (31.7% +/- 5%) in the mean ploidy of megakaryocytes suggesting a role of p19(INK4D) in the endomitotic arrest. | P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.
Gilles L, Guièze R, Bluteau D, Cordette-Lagarde V, Lacout C, Favier R, Larbret F, Debili N, Vainchenker W, Raslova H. | 01/21/2010 |
| Results describe the expression of p18(Ink4c) and p19(Ink4d) in spermatogenic and supporting cells in the testis and in pituitary gonadotropes. | p19Ink4d and p18Ink4c cyclin-dependent kinase inhibitors in the male reproductive axis.
Buchold GM, Magyar PL, Arumugam R, Lee MM, O'Brien DA. | 01/21/2010 |
| These studies indicate that a reduction in Ink4 family function by the loss of p19(Ink4d) is sufficient to induce mild reproductive defects in male mice with a mixed genetic background, but not in the C57BL/6 genetic background. | Mice lacking cyclin-dependent kinase inhibitor p19Ink4d show strain-specific effects on male reproduction.
Buchold GM, Magyar PL, O'Brien DA. | 01/21/2010 |
| p19(Ink4d) & p21(Cip1) codeletion triggers S-phase entry of auditory hair cells in early postnatal life & transient appearance of supernumerary hair cells. Aberrant cell cycle reentry activates a DNA damage response pathway & p53-mediated apoptosis. | p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.
Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U., Free PMC Article | 01/21/2010 |
| The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit. | The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit.
Cunningham JJ, Levine EM, Zindy F, Goloubeva O, Roussel MF, Smeyne RJ. | 01/21/2010 |
| Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. | Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis.
Han J, Ito Y, Yeo JY, Sucov HM, Maas R, Chai Y. | 01/21/2010 |
| Deletion of Ink4d alone is sufficient to disrupt the maintenance of the post-mitotic state of sensory hair cells in post-natal mice. In Ink4d-/- animals, hair cells re-enter the cell cycle and undergo apoptosis, resulting in progressive hearing loss. | Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d.
Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. | 01/21/2010 |