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    ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide [ Homo sapiens (human) ]

    Gene ID: 126, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    LncRNA LINC01339 Hinders the Development of Wilms' Tumor via MiR-135b-3p/ADH1C Axis.

    LncRNA LINC01339 Hinders the Development of Wilms' Tumor via MiR-135b-3p/ADH1C Axis.
    Yu Y, Liu Y.

    03/4/2024
    ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder.

    ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder.
    Kukowka A, Brzuchalski B, Kurzawski M, Malinowski D, Białecka MA., Free PMC Article

    08/9/2023
    Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam.

    Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam.
    Hoang YTT, Nguyen YT, Vu LT, Bui HTT, Nguyen QV, Vu NP, Nguyen TD, Nguyen HH., Free PMC Article

    07/5/2023
    INVESTIGATION OF ALCOHOL DEHYDROGENASE (ADH3) GENE POLYMOPHISM IN PATIENTS WITH CHRONIC ALCOHOLIC PANCRATITIS IN AZERBAIJAN POPULATION.

    INVESTIGATION OF ALCOHOL DEHYDROGENASE (ADH3) GENE POLYMOPHISM IN PATIENTS WITH CHRONIC ALCOHOLIC PANCRATITIS IN AZERBAIJAN POPULATION.
    Aliyeva G, Muslumov G, Bayramov B, Zeynalov N, Behbudov V.

    02/4/2023
    Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam.

    Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam.
    Hoang YTT, Nguyen YT, Nguyen HD, Le ATP, Bui HTT, Vu NP, Nguyen HH., Free PMC Article

    01/11/2023
    ADH1C Facilitates Cisplatin Resistance of Lung Adenocarcinoma Cells.

    ADH1C Facilitates Cisplatin Resistance of Lung Adenocarcinoma Cells.
    Jiang F, Shen Q, Zhang F, Fu J, Hu L, Wang J, Zhou H, Chen J, Wang Y.

    06/18/2022
    The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis.

    The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis.
    Song F, Zhang Y, Pan Z, Hu X, Zhang Q, Huang F, Ye X, Huang P.

    11/22/2021
    Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population.

    Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population.
    Huang YH, Chang KH, Lee YS, Chen CM, Chen YC., Free PMC Article

    11/21/2020
    Single-nucleotide polymorphism in ADH1C gene is associated with susceptibility to Multiple Head and Neck Cancers.

    Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers.
    Chien HT, Young CK, Chen TP, Liao CT, Wang HM, Cheng SD, Huang SF.

    07/18/2020
    These findings indicated that ADH1C and SPP1 might be novel promising biomarkers for predicting lung adenocarcinoma prognosis.

    Genome-wide analysis reveals alcohol dehydrogenase 1C and secreted phosphoprotein 1 for prognostic biomarkers in lung adenocarcinoma.
    Shen XY, Liu XP, Song CK, Wang YJ, Li S, Hu WD.

    06/20/2020
    Alcohol-dependent A allele carriers rs1789891 reported increased craving and higher consumption compared with the group of alcohol-dependent individuals homozygous for the C allele, which displayed craving values similar to the control group. Alcohol-dependent individuals with two C alleles had reduced gray matter volume in the left and right temporal gyri.

    Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.
    Bach P, Zois E, Vollstädt-Klein S, Kirsch M, Hoffmann S, Jorde A, Frank J, Charlet K, Treutlein J, Beck A, Heinz A, Walter H, Rietschel M, Kiefer F.

    04/4/2020
    Findings support medium to large and unique associations of ALDH2, ADH1B, and ADH1C with Alcohol Use Disorder in East Asians.

    Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians.
    Zaso MJ, Goodhines PA, Wall TL, Park A., Free PMC Article

    11/30/2019
    This first study of polymorphisms in Colombian patients diagnosed with cirrhosis and/or HCC showed genotypes ADH1B*1/1, ADH1C*1/1 and CYP2E1*C/C as the most frequent

    Polymorphisms in alcohol dehydrogenase (ADH1) and cytochrome p450 2E1 (CYP2E1) genes in patients with cirrhosis and/or hepatocellular carcinoma.
    Gaviria-Calle M, Duque-Jaramillo A, Aranzazu M, Di Filippo D, Montoya M, Roldán I, Palacio N, Jaramillo S, Restrepo JC, Hoyos S, Navas MC.

    08/24/2019
    alcohol consumption was shown to increase the risk of postmenopausal breast cancer. This association was not significantly modified by common single nucleotide polymorphisms in ADH1B and ADH1C, neither in overall breast cancer nor in hormone receptor-defined subtypes.

    Alcohol drinking, ADH1B and ADH1C genotypes and the risk of postmenopausal breast cancer by hormone receptor status: the Netherlands Cohort Study on diet and cancer.
    Hahn M, Simons CCJM, Weijenberg MP, van den Brandt PA.

    06/15/2019
    Our meta-analysis results suggested that a potential relationship between ADH1C (*)1/(*)2 polymorphism and AD risk in Turkish population.

    Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis.
    Zhang S, Wu H, Zhou H, Liang L.

    02/23/2019
    ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women.

    Alcohol intake, ADH1B and ADH1C genotypes, and the risk of colorectal cancer by sex and subsite in the Netherlands Cohort Study.
    Offermans NSM, Ketcham SM, van den Brandt PA, Weijenberg MP, Simons CCJM.

    11/3/2018
    In analysis using the ADH1B and ADH1C genotypes as instrumental variables for alcohol consumption, the hazards ratio for atrial fibrillation per genetic drink per day was 0.79 (0.44-1.41) among men and 0.64 (0.12-3.42) among women

    Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association.
    Tolstrup JS, Wium-Andersen MK, Ørsted DD, Nordestgaard BG.

    12/16/2017
    The influence of ADH3 genetic polymorphisms on the status of liver function showed significant difference according to GGT measurement, but the same cannot be said on the other two values measuring SGOT and SGPT.

    The Analysis of Polymorphism of Alcohol Dehydrogenase 3 (ADH3) Gene and Influence of Liver Function Status in Indonesia.
    Suhartini, Mustofa, Nurhantari Y, Rianto BU., Free PMC Article

    08/26/2017
    Expression of xylanase under the regulation of ADH3, AOX1 and GAP was compared.The highest enzyme production was obtained with AOX1 culture at shake-flask level.The PADH3 cultures were more productive than AOX1 and GAP at fermentor scale

    Comparison of ADH3 promoter with commonly used promoters for recombinant protein production in Pichia pastoris.
    Karaoglan M, Karaoglan FE, Inan M.

    12/17/2016
    The ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk.

    Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis.
    Fang F, Pan J, Su GH, Xu LX, Li G, Li ZH, Zhao H, Wang J.

    11/5/2016
    the combination of genotypes ADH2 * 2, CYP2E1 * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism. The role of ADH3 was not indicated.

    Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population.
    Méndez C, Rey M., Free PMC Article

    10/1/2016
    Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics

    Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.
    Roy N, Dasgupta D, Mukhopadhyay I, Chatterjee A, Das K, Bhowmik P, Das S, Basu P, Santra AK, Datta S, Dhali GK, Chowdhury A, Banerjee S., Free PMC Article

    08/13/2016
    Even at early stages of malignant transformation, a significant decrease in ADH1B, ADH3, RDHL, and RALDH1 mRNA levels was observed in 82, 79, 73, and 64% of tumor specimens, respectively

    [Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].
    Kuznetsova ES, Zinovieva OL, Oparina NY, Prokofjeva MM, Spirin PV, Favorskaya IA, Zborovskaya IB, Lisitsyn NA, Prassolov VS, Mashkova TD.

    07/2/2016
    ADH1B and ADH1C genetic variations are not related to the development of alcoholism or susceptibility to alcoholic cirrhosis.

    Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis.
    Vatansever S, Tekin F, Salman E, Altintoprak E, Coskunol H, Akarca US., Free PMC Article

    03/5/2016
    Results show that mutation of this protein confers associated protection against alcohol dependence. However these associations were not completely independent

    Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.
    Way M, McQuillin A, Saini J, Ruparelia K, Lydall GJ, Guerrini I, Ball D, Smith I, Quadri G, Thomson AD, Kasiakogia-Worlley K, Cherian R, Gunwardena P, Rao H, Kottalgi G, Patel S, Hillman A, Douglas E, Qureshi SY, Reynolds G, Jauhar S, O'Kane A, Dedman A, Sharp S, Kandaswamy R, Dar K, Curtis D, Morgan MY, Gurling HM.

    01/2/2016
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