| Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex. | Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex.
Laguardia A, Dapueto A, McCuistion H, Rossi FM. | 02/4/2023 |
| Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton. | Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton.
Wennagel D, Braz BY, Capizzi M, Barnat M, Humbert S. | 09/24/2022 |
| The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis. | The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis.
Schiavi-Ehrenhaus LJ, Romarowski A, Jabloñski M, Krapf D, Luque GM, Buffone MG., Free PMC Article | 07/2/2022 |
| The effect of cofilin 1 expression and phosphorylation dynamics on cell fate determination and neuron maturation in neural stem cells. | The effect of cofilin 1 expression and phosphorylation dynamics on cell fate determination and neuron maturation in neural stem cells.
Jiang X, Lv J, Zhou R, Xiang X. | 03/5/2022 |
| The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies. | The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.
Vignier N, Chatzifrangkeskou M, Pinton L, Wioland H, Marais T, Lemaitre M, Le Dour C, Peccate C, Cardoso D, Schmitt A, Wu W, Biferi MG, Naouar N, Macquart C, Beuvin M, Decostre V, Bonne G, Romet-Lemonne G, Worman HJ, Tedesco FS, Jégou A, Muchir A., Free PMC Article | 02/19/2022 |
| ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration. | ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration.
Luo J, Zheng H, Wang S, Li D, Ma W, Wang L, Crabbe MJC. | 02/12/2022 |
| Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death. | Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death.
Hoffmann L, Waclawczyk MS, Tang S, Hanschmann EM, Gellert M, Rust MB, Culmsee C., Free PMC Article | 02/5/2022 |
| Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin. | Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin.
McGrath J, Tung CY, Liao X, Belyantseva IA, Roy P, Chakraborty O, Li J, Berbari NF, Faaborg-Andersen CC, Barzik M, Bird JE, Zhao B, Balakrishnan L, Friedman TB, Perrin BJ., Free PMC Article | 01/29/2022 |
| hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons. | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Kim SW, Hong IK, Kim M, Song YS, Kim KT., Free PMC Article | 01/8/2022 |
| Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling. | Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling.
Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS, Tsai NP., Free PMC Article | 10/30/2021 |
| Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus. | Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Salz A, Gurniak C, Jönsson F, Witke W. | 08/7/2021 |
| Cofilin 1 promotes the aggregation and cell-to-cell transmission of alpha-synuclein in Parkinson's disease. | Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease.
Yan M, Meng L, Dai L, Zhang X, Chen G, Zheng Y, Zha Y, Zeng Y, Zhang Z. | 02/13/2021 |
| Cofilin dysregulation alters actin turnover in frataxin-deficient neurons. | Cofilin dysregulation alters actin turnover in frataxin-deficient neurons.
Muñoz-Lasso DC, Mollá B, Calap-Quintana P, García-Giménez JL, Pallardo FV, Palau F, Gonzalez-Cabo P., Free PMC Article | 12/5/2020 |
| FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation. | FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation.
Feuge J, Scharkowski F, Michaelsen-Preusse K, Korte M. | 11/21/2020 |
| Global inhibition of neddylation in developing neurons leads to cytoskeletal defects, altered actin dynamics and neurite growth impairments, whereas site-specific neddylation of cofilin 1 at K112 regulates neurite outgrowth, suggesting that cofilin 1 neddylation contributes to the regulation of neuronal actin organization. | Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M. | 04/25/2020 |
| Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage. | ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F., Free PMC Article | 03/28/2020 |
| Data suggest that response similar to nicotine withdrawal or/and hypoxia induced by childhood chronic asthma enhances the BDNF-Cdc42/RhoA signaling pathway and activates cofilin1, leading to the remodeling of actin, causing the loss of dendritic spines and atrophy of dendrites, eventually resulting in behavioral alterations. | Chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with BDNF, cofilin1 and Cdc42/RhoA alterations in immature mice.
Zhuang TT, Pan C, Chen JJ, Han F, Zhu XL, Xu H, Lu YP. | 10/5/2019 |
| The authors show that activated cofilin (S3A) preferentially forms a complex with p53 and promotes its mitochondrial and nuclear localization, resulting in transcription of p53-responsive genes and promotion of apoptosis. This cofilin-p53 pro-apoptotic pathway is subject to negative regulation by PLD1 thorough cofilin inactivation and inhibition of cofilin/p53 complex formation. | Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation.
Liu T, Wang F, LePochat P, Woo JA, Bukhari MZ, Hong KW, Trotter C, Kang DE., Free PMC Article | 06/29/2019 |
| This study evaluated four mouse models of brain ischemia to define the conditions that drive formation of cofilin-actin rods. Where acute reperfusion occurred, rod formation was maximal within 4 hours after reperfusion. Where infarction occurred, rods continued to form for at least 24 hours after ischemic onset, and extended into the adjacent non-ischemic tissue. | Cofilin-actin rod formation in neuronal processes after brain ischemia.
Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA., Free PMC Article | 03/16/2019 |
| this study reports that 5'UTR of cofilin mRNA contains an internal ribosome entry site (IRES) element, and cofilin is predominantly translated by IRES-mediated mechanism in neurons. | IRES-mediated translation of cofilin regulates axonal growth cone extension and turning.
Choi JH, Wang W, Park D, Kim SH, Kim KT, Min KT., Free PMC Article | 11/17/2018 |
| These findings suggest a causal relationship between increased Rac1-cofilin signaling, synaptic defects, and impaired sensory processing in fragile X syndrome (FXS) and uncover a previously unappreciated role for impaired Rac1-cofilin signaling in the aberrant spine morphology and spine density associated with FXS. | Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.
Pyronneau A, He Q, Hwang JY, Porch M, Contractor A, Zukin RS., Free PMC Article | 07/14/2018 |
| Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 activity | Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.
Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB., Free PMC Article | 06/9/2018 |
| These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin, CTTN, and the microtubule + ends. | The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro.
Zalli D, Neff L, Nagano K, Shin NY, Witke W, Gori F, Baron R., Free PMC Article | 12/23/2017 |
| the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse. | The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse.
Wang JC, Lee JY, Christian S, Dang-Lawson M, Pritchard C, Freeman SA, Gold MR. | 08/12/2017 |
| VEGFA induced phosphorylation of Pak1 and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta. | A new role for cofilin in retinal neovascularization.
Kumar R, Janjanam J, Singh NK, Rao GN., Free PMC Article | 01/14/2017 |