| The Regulatory Impact of CFLAR Methylation Modification on Liver Lipid Metabolism. | The Regulatory Impact of CFLAR Methylation Modification on Liver Lipid Metabolism.
Ye C, Jiang W, Hu T, Liang J, Chen Y., Free PMC Article | 09/3/2024 |
| cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma. | cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma.
Yang X, Zeng Q, İnam MG, İnam O, Lin CS, Tezel G., Free PMC Article | 06/10/2024 |
| Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. | Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Martinez Lagunas K, Savcigil DP, Zrilic M, Carvajal Fraile C, Craxton A, Self E, Uranga-Murillo I, de Miguel D, Arias M, Willenborg S, Piekarek M, Albert MC, Nugraha K, Lisewski I, Janakova E, Igual N, Tonnus W, Hildebrandt X, Ibrahim M, Ballegeer M, Saelens X, Kueh A, Meier P, Linkermann A, Pardo J, Eming S, Walczak H, MacFarlane M, Peltzer N, Annibaldi A., Free PMC Article | 09/8/2023 |
| Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury. | Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, Kuang Y, Yu Z, Geng Y, Zhao C, Tang J., Free PMC Article | 03/26/2022 |
| Oncogenic signaling inhibits c-FLIPL expression and its non-apoptotic function during ECM-detachment. | Oncogenic signaling inhibits c-FLIP(L) expression and its non-apoptotic function during ECM-detachment.
Tsegaye MA, He J, McGeehan K, Murphy IM, Nemera M, Schafer ZT., Free PMC Article | 11/13/2021 |
| c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability. | c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability.
Tomaipitinca L, Petrungaro S, D'Acunzo P, Facchiano A, Dubey A, Rizza S, Giulitti F, Gaudio E, Filippini A, Ziparo E, Cecconi F, Giampietri C., Free PMC Article | 09/25/2021 |
| Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway.
Zhai T, Xu W, Liu Y, Qian K, Xiong Y, Chen Y., Free PMC Article | 09/11/2021 |
| hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages. | hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages.
Feng J, Li H, Li J, Meng P, Wang L, Liu C, Zhao S, Sun W, Zhang Y., Free PMC Article | 08/28/2021 |
| TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP. | TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP.
Feoktistova M, Makarov R, Leverkus M, Yazdi AS, Panayotova-Dimitrova D., Free PMC Article | 03/6/2021 |
| The data demonstrate a non-redundant function of c-FLIP for the generation of NKp46(+) innate lymphoid cells, which protect T/B lymphocyte-sufficient mice from intestinal inflammation. | c-FLIP is crucial for IL-7/IL-15-dependent NKp46(+) ILC development and protection from intestinal inflammation in mice.
Bank U, Deiser K, Plaza-Sirvent C, Osbelt L, Witte A, Knop L, Labrenz R, Jänsch R, Richter F, Biswas A, Zenclussen AC, Vivier E, Romagnani C, Kühl AA, Dunay IR, Strowig T, Schmitz I, Schüler T., Free PMC Article | 05/2/2020 |
| findings reveal an important role for cFLIP in the regulation of the inflammatory response; specifically show that deficiency of the long isoform cFLIPL promotes complex II formation, driving pyroptosis, and the secretion of IL-1beta in response to LPS alone | cFLIP(L) protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation.
Muendlein HI, Jetton D, Connolly WM, Eidell KP, Magri Z, Smirnova I, Poltorak A., Free PMC Article | 03/28/2020 |
| CFLAR could be considered as a novel candidate to develop effective therapeutic treatment against cerebral I/R injury. | CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress.
Xiaohong W, Jun Z, Hongmei G, Fan Q. | 01/18/2020 |
| Caspase-8 synergizes with the canonical NLRP3 inflammasome pathway to control caspase-1 processing and IL-1beta maturation, providing a regulatory role for caspase-8 in host resistance to in vivo Paracoccidioides brasiliensis infection. | A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1β Release in Response to a Pathogenic Fungus.
Ketelut-Carneiro N, Ghosh S, Levitz SM, Fitzgerald KA, da Silva JS., Free PMC Article | 04/13/2019 |
| The antagonistic caspase 8-homolog cFLIP is a critical regulator of acute, cholestatic liver injury. | Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.
Gehrke N, Nagel M, Straub BK, Wörns MA, Schuchmann M, Galle PR, Schattenberg JM. | 03/2/2019 |
| Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis. | Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.
McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ., Free PMC Article | 02/24/2018 |
| c-FLIP modulation of AKT activity is crucial in controlling PERK signalling and sensitivity to endoplasmic reticulum stress. | A novel role of c-FLIP protein in regulation of ER stress response.
Conti S, Petrungaro S, Marini ES, Masciarelli S, Tomaipitinca L, Filippini A, Giampietri C, Ziparo E. | 12/2/2017 |
| Regulatory T cells have a high apoptosis rate ex vivo correlating with low c-FLIP expression. | c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity.
Plaza-Sirvent C, Schuster M, Neumann Y, Heise U, Pils MC, Schulze-Osthoff K, Schmitz I. | 11/25/2017 |
| In conclusion, our data indicated that miR-150 potentially contributes to the hepatic steatosis and insulin resistance in NAFLD. miR-150/CFLAR pathway may be a new therapeutic strategy against NAFLD. | MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Zhuge B, Li G. | 11/25/2017 |
| Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 dimerization are new and feasible approaches for NASH treatment. | Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Wang PX, Ji YX, Zhang XJ, Zhao LP, Yan ZZ, Zhang P, Shen LJ, Yang X, Fang J, Tian S, Zhu XY, Gong J, Zhang X, Wei QF, Wang Y, Li J, Wan L, Xie Q, She ZG, Wang Z, Huang Z, Li H. | 08/12/2017 |
| knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS accompanied by JNK1 activation to substantiate apoptosis. | Expression of FADD and cFLIP(L) balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death.
Ranjan K, Pathak C. | 02/18/2017 |
| CASP8 is present exclusively as its cleaved p43 product, bound to cFLIPL. | Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo.
Ram DR, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, Poltorak A., Free PMC Article | 07/16/2016 |
| The generation of mouse line with Flip deficiency in cells that express cre under the CD11c promoter is reported. | CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.
Huang QQ, Perlman H, Birkett R, Doyle R, Fang D, Haines GK, Robinson W, Datta S, Huang Z, Li QZ, Phee H, Pope RM., Free PMC Article | 05/7/2016 |
| c-FLIPL deficiency induces the caspase-mediated processing of RTN4, thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk. | The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria.
Marini ES, Giampietri C, Petrungaro S, Conti S, Filippini A, Scorrano L, Ziparo E., Free PMC Article | 04/9/2016 |
| Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors. | Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.
Gehrke N, Garcia-Bardon D, Mann A, Schad A, Alt Y, Wörns MA, Sprinzl MF, Zimmermann T, Menke J, Engstler AJ, Bergheim I, He YW, Galle PR, Schuchmann M, Schattenberg JM., Free PMC Article | 12/26/2015 |
| The results reveal a novel inhibitory role of c-FLIP in myeloid cell activation and demonstrate the unexpected anti-inflammatory activity of c-FLIP. | Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
Wu YJ, Wu YH, Mo ST, Hsiao HW, He YW, Lai MZ. | 12/19/2015 |