| Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2-->CNTF axis to promote progression of brain metastases. | Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases.
Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, Arrigo A, Manore SG, Wagner C, Thomas A, Singh R, Xing F, Jin G, Watabe K, Lo HW., Free PMC Article | 06/11/2022 |
| Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices. | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices.
Perugini J, Di Mercurio E, Giuliani A, Sabbatinelli J, Bonfigli AR, Tortato E, Severi I, Cinti S, Olivieri F, le Roux CW, Gesuita R, Giordano A., Free PMC Article | 06/11/2022 |
| Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRalpha) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study. | Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study.
Fantone S, Tossetta G, Montironi R, Senzacqua M, Marzioni D, Mazzucchelli R., Free PMC Article | 07/10/2021 |
| NGF and CNTF expression and regulation mechanism by miRNA in acute paralytic strabismus. | NGF and CNTF expression and regulation mechanism by miRNA in acute paralytic strabismus.
Liu H, Tan N, Xu D, Li CY, Xian GJ. | 03/13/2021 |
| Association between CNTF Polymorphisms and Adiposity Markers in European Adolescents. | Association between CNTF Polymorphisms and Adiposity Markers in European Adolescents.
Pascual-Gamarra JM, Salazar-Tortosa DF, Labayen I, Rupérez AI, Censi L, Béghin L, Michels N, Gonzalez-Gross M, Manios Y, Lambrinou CP, Moreno LA, Meirhaeghe A, Castillo MJ, Ruiz JR. | 09/12/2020 |
| Increased CNTF levels in adults with autism spectrum disorders. | Increased CNTF levels in adults with autism spectrum disorders.
Brondino N, Rocchetti M, Fusar-Poli L, Damiani S, Goggi A, Chiodelli G, Corti S, Visai L, Politi P. | 09/5/2020 |
| identify a multimodal pathway that is rate-limited by CNTF volume transmission and poised to directly convert hypothalamic activation into long-lasting cortical excitability following acute stress. | Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.
Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T., Free PMC Article | 10/5/2019 |
| This study demonstrated that hypomethylation leading to CNTFRalpha up-regulation, together with autocrine expression of CNTF, was involved in glioma growth regulation. | Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas.
Fan K, Wang X, Zhang J, Ramos RI, Zhang H, Li C, Ye D, Kang J, Marzese DM, Hoon DSB, Hua W., Free PMC Article | 02/16/2019 |
| Our findings suggest that CNTF over-expression enhances the protective effects of bone marrow mesenchymal stem cells on retinal pigment epithelium cells, thus indicating subretinal-transplantation of CNTF-bone marrow mesenchymal stem cells may be a promising therapy for blue-light -injured retina | Over-expression of CNTF in bone marrow mesenchymal stem cells protects RPE cells from short-wavelength, blue-light injury.
Lin W, Xu G. | 09/22/2018 |
| Cytokines of the LIF/CNTF family and metabolism | Cytokines of the LIF/CNTF family and metabolism.
Pasquin S, Sharma M, Gauchat JF. | 12/16/2017 |
| High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration. | High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration.
Wang Q, Liu Y, Zhang C, Guo F, Feng C, Li X, Shi H, Su Z. | 07/22/2017 |
| CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRalpha-LIFRbeta-gp130 receptor. | Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies.
Pasquin S, Sharma M, Gauchat JF. | 06/28/2016 |
| Human CNTF expression through lentiviral gene transfer in the rat striatum significantly decreased the levels of neuronal metabolites (N-acetyl-aspartate, N-acetyl-aspartyl-glutamate, and glutamate). | The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study.
Carrillo-de Sauvage MA, Flament J, Bramoulle Y, Ben Haim L, Guillermier M, Berniard A, Aurégan G, Houitte D, Brouillet E, Bonvento G, Hantraye P, Valette J, Escartin C., Free PMC Article | 08/15/2015 |
| the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells and the underlying molecular mechanism of this effect were investigated for the first time | Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells.
Wang K, Zhou F, Zhu X, Zhang K, Huang B, Zhu L, Zhu L. | 04/11/2015 |
| R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR. | The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J., Free PMC Article | 10/18/2014 |
| In this review, CNTF plays an important role in neurogenesis and differentiation of neural stem cells. | Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.
Ding J, He Z, Ruan J, Ma Z, Liu Y, Gong C, Iqbal K, Sun S, Chen H. | 06/28/2014 |
| The levels of expression and secretion of BDNF and CTNF of induced cells were assessed using immunocytochemical, Real-Time polymerase chain reaction, and enzyme linked immunosorbent assay (ELISA). | Comparing brain-derived neurotrophic factor and ciliary neurotrophic factor secretion of induced neurotrophic factor secreting cells from human adipose and bone marrow-derived stem cells.
Razavi S, Razavi MR, Zarkesh Esfahani H, Kazemi M, Mostafavi FS. | 06/7/2014 |
| CNTF elevated in umbilical cord blood from pre-eclamptic pregnancies | Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies.
Bienertova-Vasku J, Bienert P, Zlamal F, Splichal Z, Tomandl J, Tomandlova M, Hodicka Z, Ventruba P, Vasku A. | 04/26/2014 |
| CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells. | CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells.
Rhee KD, Nusinowitz S, Chao K, Yu F, Bok D, Yang XJ., Free PMC Article | 01/25/2014 |
| Report favourable allelic patterns of ACTN3 and CNTF genes on aerobic performance in athletes. | Polymorphisms of alpha-actinin-3 and ciliary neurotrophic factor in national-level Italian athletes.
Persi A, Maltese PE, Bertelli M, Cecchin S, Ciaghi M, Guarnieri MC, Agnello L, Maggioni MA, Merati G, Veicsteinas A. | 12/7/2013 |
| Data indicate that aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. | Up-regulation of ciliary neurotrophic factor in astrocytes by aspirin: implications for remyelination in multiple sclerosis.
Modi KK, Sendtner M, Pahan K., Free PMC Article | 09/7/2013 |
| we show that the release of CNTF by glial cells is a very powerful stimulus for optic fiber regeneration and retinal ganglion cell survival after optic nerve crush | Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve.
Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME. | 07/27/2013 |
| Ciliary neurotrophic factor levels were increased in painful PTT only. | Increased expression of IL-6 family members in tendon pathology.
Legerlotz K, Jones ER, Screen HR, Riley GP., Free PMC Article | 09/8/2012 |
| Peptide 6c, corresponding to human CNTF amino acid residues 147-150, induces neurogenesis, neuronal activity and proliferation of immature neurons in the dentate gyrus and improvement of spatial reference memory in mice. | Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice.
Blanchard J, Chohan MO, Li B, Liu F, Iqbal K, Grundke-Iqbal I. | 02/4/2012 |
| CNTF's effects on retinal pigment epithelial (RPE) physiology | CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium.
Li R, Wen R, Banzon T, Maminishkis A, Miller SS., Free PMC Article | 12/31/2011 |