| Identification of an Electrogenic 2Cl[-]/H[+] Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis. | Identification of an Electrogenic 2Cl(-)/H(+) Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis.
Barone S, Brooks M, Zahedi K, Holliday LS, Bissler J, Yu JJ, Soleimani M., Free PMC Article | 02/4/2023 |
| This study demonistrated that Clcn5 gene expression in mouse dorsal raphe nucleus | Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG., Free PMC Article | 09/15/2012 |
| ClC-5 plays an essential role in exocytosis of NHE3. | Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).
Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, Cha B, Hubbard A, Donowitz M, Guggino SE., Free PMC Article | 09/10/2011 |
| HNF1alpha directly regulates the expression of ClC-5 in the renal proximal tubule | The transcription factor HNF1α regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule.
Tanaka K, Terryn S, Geffers L, Garbay S, Pontoglio M, Devuyst O. | 01/15/2011 |
| ClC-5 is unique among CLC proteins in being crucial for proximal tubular endocytosis and the PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this rol | Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.
Rickheit G, Wartosch L, Schaffer S, Stobrawa SM, Novarino G, Weinert S, Jentsch TJ., Free PMC Article | 06/28/2010 |
| findings show that endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by H+-ATPase, may play a role in endocytosis | Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino G, Weinert S, Rickheit G, Jentsch TJ. | 06/28/2010 |
| Our studies demonstrate a role for CLC-5 in the immunopathogenesis of ulcerative colitis | Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis.
Alex P, Ye M, Zachos NC, Sipes J, Nguyen T, Suhodrev M, Gonzales L, Arora Z, Zhang T, Centola M, Guggino SE, Li X., Free PMC Article | 05/3/2010 |
| ClC-5 regulates dentin development through TGF-beta1 pathway | ClC-5 regulates dentin development through TGF-beta1 pathway.
Duan X, Mao Y, Yang T, Wen X, Wang H, Hou J, Xue Y, Zhang R. | 04/12/2010 |
| in the thyroid, unlike in the kidney, ClC-5 does not affect megalin expression and function | ClC-5 does not affect megalin expression and function in the thyroid.
Maritzen T, Lisi S, Botta R, Pinchera A, Fanelli G, Viacava P, Marcocci C, Marinò M. | 01/21/2010 |
| lack of proximal tubule cLCN5 in mice and men is associated with CAIII induction, increased cell proliferation, and oxidative stress | A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.
Gailly P, Jouret F, Martin D, Debaix H, Parreira KS, Nishita T, Blanchard A, Antignac C, Willnow TE, Courtoy PJ, Scheinman SJ, Christensen EI, Devuyst O. | 01/21/2010 |
| observed a significant decrease in solute carrier family 2 protein expression levels in isolated proximal tubule ((n=10, p<0.01)) of knockout mice | Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression.
Souza-Menezes J, Morales MM, Tukaye DN, Guggino SE, Guggino WB. | 01/21/2010 |
| High citrate diet preserved renal function and delayed progression of renal disease in ClC-5 knockout mice even in the apparent absence of stone formation. | High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease.
Cebotaru V, Kaul S, Devuyst O, Cai H, Racusen L, Guggino WB, Guggino SE. | 01/21/2010 |
| hypercalciuria in the ClC-5 KO mice on low and high calcium diets is of bone and renal origin and is not caused by increased intestinal calcium absorption | The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE. | 01/21/2010 |
| The segmental expression of ClC-5 and H+-ATPase is essentially achieved during early nephrogenesis, in parallel with the onset of glomerular filtration. | Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
Jouret F, Igarashi T, Gofflot F, Wilson PD, Karet FE, Thakker RV, Devuyst O. | 01/21/2010 |
| Our results provide direct evidence for ClC-5 involvement in acidification of early endosomes in proximal tubule by a chloride shunt mechanism. | Impaired acidification in early endosomes of ClC-5 deficient proximal tubule.
Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. | 01/21/2010 |
| A role for CBS domain 2 in transport of CLC-5. | A role for CBS domain 2 in trafficking of chloride channel CLC-5.
Carr G, Simmons N, Sayer J. | 01/21/2010 |
| collecting duct cells with reduced CLC-5 expression lead to a tendency to form calcium crystal agglomeration | Calcium phosphate and calcium oxalate crystal handling is dependent upon CLC-5 expression in mouse collecting duct cells.
Sayer JA, Carr G, Simmons NL. | 01/21/2010 |
| ClC-5 has a role in apical iodide efflux and in euthyroid goiter in the mouse thyroid gland | The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
van den Hove MF, Croizet-Berger K, Jouret F, Guggino SE, Guggino WB, Devuyst O, Courtoy PJ. | 01/21/2010 |
| Disruption of CLC-5 expression causes abnormal calcium crystal agglomeration on the surface of kidney collecting duct cells. | Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cells.
Sayer JA, Carr G, Pearce SH, Goodship TH, Simmons NL. | 01/21/2010 |
| increased CLC-5 levels in mouse medullary thick ascending limb may serve to maintain the endocytotic activity in a hypertonic environment. | Hypertonicity increases CLC-5 expression in mouse medullary thick ascending limb cells.
Pham PC, Devuyst O, Pham PT, Matsumoto N, Shih RN, Jo OD, Yanagawa N, Sun AM. | 01/21/2010 |
| Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin and cubilin in PTC. | Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
Christensen EI, Devuyst O, Dom G, Nielsen R, Van der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ., Free PMC Article | 01/21/2010 |
| Target genes of 1,25(OH)(2)-vitamin D(3) were upregulated in ClC-5 knockout kidneys. | Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.
Maritzen T, Rickheit G, Schmitt A, Jentsch TJ. | 01/21/2010 |