| Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function. | Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function.
Sun Z, Sen H, Zhu X, Islam SA., | 12/6/2023 |
| CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. | CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S., Free PMC Article | 03/12/2022 |
| Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry. | Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry.
Tanaka T, Nanamiya R, Takei J, Nakamura T, Yanaka M, Hosono H, Sano M, Asano T, Kaneko MK, Kato Y. | 01/8/2022 |
| Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis. | Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis.
Honda F, Tsuboi H, Ono Y, Abe S, Takahashi H, Ito K, Yamada K, Kawano M, Kondo Y, Asano K, Tanaka M, Malissen M, Malissen B, Matsumoto I, Sumida T., Free PMC Article | 09/11/2021 |
| CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. | CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis.
Kang L, Schmalzl A, Leupold T, Gonzalez-Acera M, Atreya R, Neurath MF, Becker C, Wirtz S., Free PMC Article | 06/26/2021 |
| Disruption of the CCL1-CCR8 axis promotes atherosclerosis. | Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice.
Vila-Caballer M, González-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sánchez P, Ait-Oufella H, Andrés-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutiérrez J, Mallat Z, Andrés V. | 06/27/2020 |
| this study shows that the chemokine receptor CCR8 promotes the migration of dendritic cells into the lymph node parenchyma to initiate the allergic immune response | The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response.
Sokol CL, Camire RB, Jones MC, Luster AD., Free PMC Article | 04/13/2019 |
| CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. | CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.
Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, Iwakura Y. | 12/19/2015 |
| Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. | Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.
Oshio T, Kawashima R, Kawamura YI, Hagiwara T, Mizutani N, Okada T, Otsubo T, Inagaki-Ohara K, Matsukawa A, Haga T, Kakuta S, Iwakura Y, Hosokawa S, Dohi T., Free PMC Article | 12/6/2014 |
| A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. | CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.
Coghill JM, Fowler KA, West ML, Fulton LM, van Deventer H, McKinnon KP, Vincent BG, Lin K, Panoskaltsis-Mortari A, Cook DN, Blazar BR, Serody JS., Free PMC Article | 11/2/2013 |
| Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. | Effects of chemokine (C-C motif) ligand 1 on microglial function.
Akimoto N, Ifuku M, Mori Y, Noda M. | 09/14/2013 |
| C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity | C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.
Denis C, Deiteren K, Mortier A, Tounsi A, Fransen E, Proost P, Renauld JC, Lambeir AM., Free PMC Article | 11/17/2012 |
| Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. | Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice.
Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Rüsseler V, Gassler N, Lira SA, Luedde T, Trautwein C, Tacke F., Free PMC Article | 05/19/2012 |
| a key regulator of Th2 cell skin recruitment during IL-5-mediated allergic inflammation | Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD., Free PMC Article | 06/18/2011 |
| Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. | Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.
Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD., Free PMC Article | 01/21/2010 |
| CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation | Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1.
Cantor J, Haskins K. | 01/21/2010 |
| Results suggest that CCR8 plays a significant role in the pathogenesis of experimental autoimmune encephalomyelitis and probalby of multiple sclerosis. | Expression of chemokine receptors CCR7 and CCR8 in the CNS during ChREAE.
Bielecki B, Mazurek A, Wolinski P, Glabinski A. | 01/21/2010 |
| Mast cell-derived CCR8- and CCL1-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. | Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.
Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez-A C, Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJ. | 01/21/2010 |
| mediates increased responsiveness of murine eosinophils to TCA-3 | Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8.
Oliveira SH, Lira S, Martinez-A C, Wiekowski M, Sullivan L, Lukacs NW. | 01/21/2010 |
| Ccr8 has a pivotal role in the progression of experimental fungal asthma. | Remission of chronic fungal asthma in the absence of CCR8.
Buckland KF, O'connor EC, Coleman EM, Lira SA, Lukacs NW, Hogaboam CM. | 01/21/2010 |
| IL-10 production correlates with CCR8 ligand (CCL1) expression and the appearance of CCR8+ cells in granulomatous lungs and is required for full expression of the T helper type 2 cell response to parasite antigens. | CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice.
Freeman CM, Chiu BC, Stolberg VR, Hu J, Zeibecoglou K, Lukacs NW, Lira SA, Kunkel SL, Chensue SW., Free PMC Article | 01/21/2010 |
| CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. | CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes.
Soler D, Chapman TR, Poisson LR, Wang L, Cote-Sierra J, Ryan M, McDonald A, Badola S, Fedyk E, Coyle AJ, Hodge MR, Kolbeck R. | 01/21/2010 |
| sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence | Analysis of post-translational CCR8 modifications and their influence on receptor activity.
Gutiérrez J, Kremer L, Zaballos A, Goya I, Martínez-A C, Márquez G. | 01/21/2010 |
| CCR8 ligands are allotropic, binding to distinct sites within CCR8 | Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.
Fox JM, Najarro P, Smith GL, Struyf S, Proost P, Pease JE. | 01/21/2010 |
| CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity. | Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis.
Matsukawa A, Kudoh S, Sano G, Maeda T, Ito T, Lukacs NW, Hogaboam CM, Kunkel SL, Lira SA. | 01/21/2010 |