| Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss. | Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss.
Verdoodt D, Peeleman N, Szewczyk K, Van Camp G, Ponsaerts P, Van Rompaey V., Free PMC Article | 12/18/2021 |
| Upon infection, the LCCL domain is cleaved from cochlin and secreted into the perilymph. This cleaved fragment sequesters infiltrating bacteria in the scala tympani and subsequently recruits resident immune cells to eliminate the bacteria. | Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear.
Jung J, Yoo JE, Choe YH, Park SC, Lee HJ, Lee HJ, Noh B, Kim SH, Kang GY, Lee KM, Yoon SS, Jang DS, Yoon JH, Hyun YM, Choi JY. | 11/23/2019 |
| accumulation of acellular deposits in the incudomalleal and incudostapedial joints in Coch (G88E/G88E) mice similar to those found in human DFNA9-affected temporal bones | Cochlin in normal middle ear and abnormal middle ear deposits in DFNA9 and Coch (G88E/G88E) mice.
Robertson NG, O'Malley JT, Ong CA, Giersch AB, Shen J, Stankovic KM, Morton CC., Free PMC Article | 07/25/2015 |
| study reports that cochlin is expressed by follicular dendritic cells (FDCs) and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes; by producing cochlin, FDCs contribute to the innate immune response in defense against bacteria | Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J., Free PMC Article | 08/3/2013 |
| COCH is a part of the downstream target network of BMP4 signaling and serves as another important effector to fine-tune mouse embryonic stem cell fates. | BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells.
Zhang J, Fei T, Li Z, Zhu G, Wang L, Chen YG., Free PMC Article | 05/18/2013 |
| Loss of Cochlin is associated with reduced intraocular pressure and mechanosensing. | Cochlin, intraocular pressure regulation and mechanosensing.
Goel M, Sienkiewicz AE, Picciani R, Wang J, Lee RK, Bhattacharya SK., Free PMC Article | 08/25/2012 |
| In Coch knock-in/knockout mouse models of sensorineural hearing loss and vestibular dysfunction vestibular function is compromised before cochlear function. | Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder.
Jones SM, Robertson NG, Given S, Giersch AB, Liberman MC, Morton CC., Free PMC Article | 06/18/2011 |
| Up-regulation of cochlin is an important etiologic factor leading to Usher syndrome type 1F. | Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F.
Chance MR, Chang J, Liu S, Gokulrangan G, Chen DH, Lindsay A, Geng R, Zheng QY, Alagramam K., Free PMC Article | 09/20/2010 |
| introduced the G88E mutation by gene targeting into the mouse and have created a Coch(G88E/G88E) mouse model for the study of DFNA9 pathogenesis and cochlin function | A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction.
Robertson NG, Jones SM, Sivakumaran TA, Giersch AB, Jurado SA, Call LM, Miller CE, Maison SF, Liberman MC, Morton CC., Free PMC Article | 01/21/2010 |
| Cochlin was found in the trabecular meshwork of very young mice, prior to elevated intraocular pressure, suggesting that over time the protein may contribute to the events leading to increased IOP and optic nerve damage--{REVIEW} | Cochlin and glaucoma: a mini-review.
Bhattacharya SK, Peachey NS, Crabb JW., Free PMC Article | 01/21/2010 |
| gene expression in glaucomatous trabecular meshwork | Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork.
Bhattacharya SK, Rockwood EJ, Smith SD, Bonilha VL, Crabb JS, Kuchtey RW, Robertson NG, Peachey NS, Morton CC, Crabb JW., Free PMC Article | 01/21/2010 |
| Areas that express COCH mRNA as determined by in situ hybridization, and to the regions of the inner ear which show histological abnormalities in autosomal dominant sensorineural deafness and vestibular disorder, DFNA9. | Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9.
Robertson NG, Resendes BL, Lin JS, Lee C, Aster JC, Adams JC, Morton CC. | 01/21/2010 |