| Collagen 17A1 in the Urothelium Regulates Epithelial Cell Integrity and Local Immunologic Responses in Obstructive Uropathy. | Collagen 17A1 in the Urothelium Regulates Epithelial Cell Integrity and Local Immunologic Responses in Obstructive Uropathy.
Namba T, Ichii O, Natsuga K, Nakamura T, Otani Y, Kon Y. | 09/3/2024 |
| NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1. | NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
Cao JH, Cao CH, Lin JL, Li SY, He LJ, Han K, Chen JW, Li S, Wang X, Xie D, Wang FW. | 02/5/2024 |
| Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice. | Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice.
Sproule TJ, Wilpan RY, Low BE, Silva KA, Reyon D, Joung JK, Wiles MV, Roopenian DC, Sundberg JP., Free PMC Article | 11/1/2023 |
| This study provides the first direct evidence that BP180, a cell-cell matrix adhesion molecule, possesses antitumor function through modulating infiltration of myeloid derived suppressor cells. | The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression.
Hwang BJ, Zhang Y, Brozowski JM, Liu Z, Burette S, Lough K, Smith CC, Shan Y, Chen J, Li N, Williams S, Su M, Googe P, Thomas NE, Liu Z., Free PMC Article | 03/14/2020 |
| These results suggest that COL17A1 is important in differentiation of HAP stem cells. | Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation.
Shirai K, Obara K, Tohgi N, Yamazaki A, Aki R, Hamada Y, Arakawa N, Singh SR, Hoffman RM, Amoh Y. | 01/11/2020 |
| Here, the authors show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. | Type XVII collagen coordinates proliferation in the interfollicular epidermis.
Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Tsukiyama T, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H., Free PMC Article | 03/17/2018 |
| The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ. | Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, Nishimura EK. | 03/26/2016 |
| The deletion of the bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in a mouse disease model. | Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice.
Hurskainen T, Kokkonen N, Sormunen R, Jackow J, Löffek S, Soininen R, Franzke CW, Bruckner-Tuderman L, Tasanen K. | 07/25/2015 |
| Collagen XVII has a function in the attachment of podocyte foot processes to the glomerular basement membrane. | Transmembrane collagen XVII is a novel component of the glomerular filtration barrier.
Hurskainen T, Moilanen J, Sormunen R, Franzke CW, Soininen R, Loeffek S, Huilaja L, Nuutinen M, Bruckner-Tuderman L, Autio-Harmainen H, Tasanen K. | 05/4/2015 |
| Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2(jeb) mice | Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice.
Sproule TJ, Bubier JA, Grandi FC, Sun VZ, Philip VM, McPhee CG, Adkins EB, Sundberg JP, Roopenian DC., Free PMC Article | 12/20/2014 |
| These results provide mechanistic evidence that ColXVII coordinates keratinocyte adhesion and directed motility by interfering integrin dependent PI3K activation and by stabilizing lamellipodia | Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling.
Löffek S, Hurskainen T, Jackow J, Sigloch FC, Schilling O, Tasanen K, Bruckner-Tuderman L, Franzke CW., Free PMC Article | 11/22/2014 |
| Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid | Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro SD, An L, Giudice GJ, Diaz LA, Senior RM, Liu Z., Free PMC Article | 05/5/2012 |
| Collagen XXVII plays an important structural role in the pericellular extracellular matrix of the growth plate and is required for the organisation of the proliferative zone | Collagen XXVII organises the pericellular matrix in the growth plate.
Plumb DA, Ferrara L, Torbica T, Knowles L, Mironov A Jr, Kadler KE, Briggs MD, Boot-Handford RP., Free PMC Article | 04/28/2012 |
| Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of hair follicle stem cells through maintaining their quiescence and immaturity. | Hair follicle stem cells provide a functional niche for melanocyte stem cells.
Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK. | 05/14/2011 |
| ADAM9 and ADAM10 can both contribute to collagen XVII shedding in skin. | Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.
Franzke CW, Bruckner-Tuderman L, Blobel CP., Free PMC Article | 01/21/2010 |
| bullous pemphigoid antigen 2 has a role in eliciting specific IgG and the immune responses arising in epidermolysis bullosa | Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice.
Olasz EB, Roh J, Yee CL, Arita K, Akiyama M, Shimizu H, Vogel JC, Yancey KB., Free PMC Article | 01/21/2010 |