| Collagen IX deficiency leads to premature vascularization and ossification of murine femoral heads through an imbalance of pro- and antiangiogenic factors. | Collagen IX deficiency leads to premature vascularization and ossification of murine femoral heads through an imbalance of pro- and antiangiogenic factors.
Heilig J, Dietmar HF, Brachvogel B, Paulsson M, Zaucke F, Niehoff A. | 07/31/2021 |
| An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col IX -/- mice and, as a result, to the early onset of disc degeneration. | Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.
Kamper M, Paulsson M, Zaucke F. | 06/3/2017 |
| Results show that absence of Col IX induces early developmental, structural and biomechanical alterations in both vertebral body and intervertebral disc which eventually cause severe degenerative changes in the aging spine. | Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice.
Kamper M, Hamann N, Prein C, Clausen-Schaumann H, Farkas Z, Aszodi A, Niehoff A, Paulsson M, Zaucke F. | 12/17/2016 |
| Proteomic analysis of interaction partners of collagen alpha1 IX in the articular cartilage of mice. | Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.
Brachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, Dayakli M, Koch M, Gorman JJ, Bateman JF, Wilson R., Free PMC Article | 07/13/2013 |
| They test the hypothesis that aged Col9a1(-/-) mice would reduce joint pain by adopting locomotor behaviors that reduce both the magnitude and daily frequency of joint loading. | Locomotor activity and gait in aged mice deficient for type IX collagen.
Costello KE, Guilak F, Setton LA, Griffin TM., Free PMC Article | 10/23/2010 |
| Loss of type IX collagen and COMP leads to matrix aberrations that may make cartilage more susceptible to degeneration. | Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures.
Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F. | 02/22/2010 |
| Col9a1(-/-) mice present behavioral changes consistent with anatomic signs of osteoarthritis and intervertebral disc degeneration. | Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.
Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, Boyd LM, Setton LA., Free PMC Article | 01/21/2010 |
| all long bones are shorter and broader in newborn Col9a1-/- mice | Collagen IX-deficiency seriously compromises growth cartilage development in mice.
Dreier R, Opolka A, Grifka J, Bruckner P, Grässel S. | 01/21/2010 |
| mineralized bone matrix deficient of short collagen IX may become susceptible to osteoclastic bone resorption, possibly through a novel non-cell-autonomous mechanism | Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone.
Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I., Free PMC Article | 01/21/2010 |
| A deletion mutation for type IX collagen is associated with connective tissue changes characteristic of musculoskeletal degeneration in bony and cartilaginous tissue regions | Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen.
Boyd LM, Richardson WJ, Allen KD, Flahiff C, Jing L, Li Y, Chen J, Setton LA. | 01/21/2010 |
| ColVa1+/- and ColXIa1-/- mutants were used to identify roles for ColVa1 and ColXIa1 in ventricular myocardial morphogenesis and heart valve development. | ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development.
Lincoln J, Florer JB, Deutsch GH, Wenstrup RJ, Yutzey KE. | 01/21/2010 |
| Endochondral bone formation can occur in collagen IX knockout mice but is impaired under conditions of stress, such as the repair of an unfixed fractured long bone. | Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice.
Opolka A, Ratzinger S, Schubert T, Spiegel HU, Grifka J, Bruckner P, Probst A, Grässel S. | 01/21/2010 |
| the genes encoding each chain of type IX collagen may fulfill an important function associated with the tectorial membrane in the auditory system. | Type IX collagen is crucial for normal hearing.
Asamura K, Abe S, Imamura Y, Aszodi A, Suzuki N, Hashimoto S, Takumi Y, Hayashi T, Fässler R, Nakamura Y, Usami S. | 01/21/2010 |
| Type IX collagen knock-out mouse shows progressive hearing loss. | Type IX collagen knock-out mouse shows progressive hearing loss.
Suzuki N, Asamura K, Kikuchi Y, Takumi Y, Abe S, Imamura Y, Hayashi T, Aszodi A, Fässler R, Usami S. | 01/21/2010 |