| Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation. | Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation.
Ichioka K, Yoshikawa T, Kimura H, Saito R., Free PMC Article | 06/21/2024 |
| PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency. | PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.
Kardelen AD, Najafli A, Baş F, Karaman B, Toksoy G, Poyrazoğlu Ş, Avcı Ş, Altunoğlu U, Yavaş Abalı Z, Öztürk AP, Karakılıç Özturan E, Başaran S, Darendeliler F, Uyguner ZO., Free PMC Article | 11/28/2023 |
| Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease. | Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.
Zeng L, Wang C, Song Z, Liu Q, Chen D, Yu X. | 11/20/2023 |
| A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism. | A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.
Wang X, Chen D, Zhao Y, Men M, Chen Z, Jiang F, Zheng R, Stamou MI, Plummer L, Balasubramanian R, Li JD., Free PMC Article | 05/11/2023 |
| Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review. | Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
Sugisawa C, Taniyama M, Sato T, Takahashi Y, Hasegawa T, Narumi S. | 09/10/2022 |
| [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism]. | [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].
Xie YD, Zheng RZ, Han HJ, Yuan JD, Li J. | 08/13/2022 |
| Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress. | Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.
Song YB, Park SY, Park K, Hwang H, Carroll RS, Hsu VW, Kaiser UB., Free PMC Article | 03/19/2022 |
| Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations. | Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.
Li S, Zhao Y, Nie M, Yang Y, Hao M, Mao J, Wu X. | 03/5/2022 |
| Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2. | Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Casella I, Ambrosio C. | 01/22/2022 |
| Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers. | Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.
Fullone MR, Lattanzi R, Maftei D, Bonaccorsi MC, Miele R. | 07/3/2021 |
| Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty. | Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty.
Aiello F, Cirillo G, Cassio A, Di Mase R, Tornese G, Umano GR, Miraglia Del Giudice E, Grandone A., Free PMC Article | 02/6/2021 |
| 18 of135 idiopathic hypogonadotropic hypogonadism patients in China carried mutations in PROKR2. Most of the variants were private; however, a PROKR2 (c.533G > C; p.W178S) mutation was identified in 10 independent patients, implying a possible founder mutation. 6 novel PROKR2 mutations led to decreased signaling to various extents. L218P and R270H disrupted Galphaq-dependent signaling but had normal Galphas and ERK1/2 ... | PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα-protein leads to biased signaling.
Zhao Y, Wu J, Jia H, Wang X, Zheng R, Jiang F, Chen DN, Chen Z, Li JD. | 05/16/2020 |
| infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells. | Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N. | 07/27/2019 |
| Findings suggest that in vitro modeling of WT/Mutant interactions increases the resolution for identifying causal variants, uncovers novel dominant negative mutations, and provides new insights into the pathogenic mechanisms underlying heterozygous PROKR2 variants. | Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency.
Cox KH, Oliveira LMB, Plummer L, Corbin B, Gardella T, Balasubramanian R, Crowley WF., Free PMC Article | 01/5/2019 |
| EG-VEGF and PROKR2 were highly expressed in colorectal primary lesions compared to positive controls. PROKR1 expression was lower and did not change in tumor specimens. | Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor PROKR2 are associated to human colorectal cancer progression and peritoneal carcinomatosis.
Benlahfid M, Traboulsi W, Sergent F, Benharouga M, Elhattabi K, Erguibi D, Karkouri M, Elattar H, Fadil A, Fahmi Y, Aboussaouira T, Alfaidy N. | 08/25/2018 |
| The deletion contained 17 protein coding genes including PROKR2 and BMP2, both of which are expressed during embryological development of the pituitary gland. PROKR2 mutations have been associated with hypopituitarism but a heterozygous deletion of this gene with hypopituitarism is a novel observation. | A heterozygous microdeletion of 20p12.2-3 encompassing PROKR2 and BMP2 in a patient with congenital hypopituitarism and growth hormone deficiency.
Parsons SJH, Wright NB, Burkitt-Wright E, Skae MS, Murray PG. | 12/2/2017 |
| PROKR2 genetic mutation plays a role in the pathogenesis of pituitary stalk interruption syndrome. | Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome.
McCormack SE, Li D, Kim YJ, Lee JY, Kim SH, Rapaport R, Levine MA., Free PMC Article | 10/7/2017 |
| a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL) (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population. | Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.
Cao YL, Zhang ZF, Wang J, Miao MH, Xu JH, Shen YP, Chen AM, Du J, Yuan W., Free PMC Article | 12/24/2016 |
| Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] | Prokineticins in central and peripheral control of human reproduction.
Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, Hoffmann P, Feige JJ, Benharouga M, Alfaidy N. | 09/10/2016 |
| PROKR2 may play a role in susceptibility of pituitary stalk interruption syndrome | Correlation between Pituitary Stalk Interruption Syndrome and Prokineticin Receptor 2 and Prokineticin 2 Mutations.
Han BY, Li LL, Wang CZ, Guo QH, Lv ZH, Mu YM, Dou JT. | 07/16/2016 |
| PROKR2 expression in human fetal ovary remained unchanged throughout gestation. | Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
Eddie SL, Childs AJ, Kinnell HL, Brown P, Jabbour HN, Anderson RA. | 11/28/2015 |
| EG-VEGF, BV8, and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis lungs compared with controls. | EG-VEGF, BV8, and their receptor expression in human bronchi and their modification in cystic fibrosis: Impact of CFTR mutation (delF508).
Chauvet S, Traboulsi W, Thevenon L, Kouadri A, Feige JJ, Camara B, Alfaidy N, Benharouga M. | 10/17/2015 |
| PKR2 protomers form type II dimers involving TMs 4 and 5, with a role for TM5 in modulation of PKR2 function. | Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers.
Sposini S, Caltabiano G, Hanyaloglu AC, Miele R. | 08/8/2015 |
| Study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants. | Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.
Su MT, Lin SH, Chen YC, Kuo PL. | 11/29/2014 |
| PK2-induced PKR2 endocytosis is GRK2- and clathrin-dependent, but beta-arrestin-independent. | Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor.
Yin W, Liu H, Peng Z, Chen D, Li J, Li JD. | 11/8/2014 |