| CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice. | CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice.
Luo S, Guo L, Chen N, Guo Q, Xie Y, Wang Y, Wang E., Free PMC Article | 08/14/2024 |
| Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2. | Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2.
Parlak GC, Baris I, Gul S, Kavakli IH., Free PMC Article | 01/31/2024 |
| CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4. | CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Lin L, Huang Y, Wang J, Guo X, Yu F, He D, Wu C, Guo L, Wu B. | 12/5/2023 |
| CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability. | CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
Deng M, Wang Z, Luo J, Cao H, Li Y, Chen L, Liu G., Free PMC Article | 07/13/2023 |
| The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization. | The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization.
Parlak GC, Camur BB, Gul S, Ozcan O, Baris I, Kavakli IH., Free PMC Article | 10/15/2022 |
| Role of heterozygous and homozygous alleles in cryptochrome-deficient mice. | Role of heterozygous and homozygous alleles in cryptochrome-deficient mice.
Oda Y, Takasu NN, Ohno SN, Shirakawa Y, Sugimura M, Nakamura TJ, Nakamura W. | 03/26/2022 |
| CRY2 missense mutations suppress P53 and enhance cell growth. | CRY2 missense mutations suppress P53 and enhance cell growth.
Chan AB, Parico GCG, Fribourgh JL, Ibrahim LH, Bollong MJ, Partch CL, Lamia KA., Free PMC Article | 12/4/2021 |
| Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Miller S, Srivastava A, Nagai Y, Aikawa Y, Tama F, Hirota T., Free PMC Article | 12/4/2021 |
| Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits. | Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.
Maywood ES, Chesham JE, Winsky-Sommerer R, Hastings MH., Free PMC Article | 11/27/2021 |
| CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping. | CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping.
Putker M, Wong DCS, Seinkmane E, Rzechorzek NM, Zeng A, Hoyle NP, Chesham JE, Edwards MD, Feeney KA, Fischer R, Peschel N, Chen KF, Vanden Oever M, Edgar RS, Selby CP, Sancar A, O'Neill JS., Free PMC Article | 10/23/2021 |
| An in-depth neurobehavioral characterization shows anxiety-like traits, impaired habituation behavior, and restlessness in male Cryptochrome-deficient mice. | An in-depth neurobehavioral characterization shows anxiety-like traits, impaired habituation behavior, and restlessness in male Cryptochrome-deficient mice.
Hühne A, Volkmann P, Stephan M, Rossner M, Landgraf D. | 08/21/2021 |
| Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis. | Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis.
Bekki H, Duffy T, Okubo N, Olmer M, Alvarez-Garcia O, Lamia K, Kay S, Lotz M., Free PMC Article | 07/31/2021 |
| Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. | Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.
Weger BD, Gobet C, David FPA, Atger F, Martin E, Phillips NE, Charpagne A, Weger M, Naef F, Gachon F., Free PMC Article | 05/15/2021 |
| myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion. | Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b.
Lowe M, Lage J, Paatela E, Munson D, Hostager R, Yuan C, Katoku-Kikyo N, Ruiz-Estevez M, Asakura Y, Staats J, Qahar M, Lohman M, Asakura A, Kikyo N., Free PMC Article | 06/1/2019 |
| Circadian clock cryptochrome proteins Cry1 and Cry2 regulate autoimmunity. | Circadian clock cryptochrome proteins regulate autoimmunity.
Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP., Free PMC Article | 06/30/2018 |
| CRY1/2 seem to repress a distinct subset of PPAR delta target genes in muscle compared to the co-repressor NCOR1. In vivo, genetic disruption of Cry1 and Cry2 enhances sprint exercise performance in mice. | CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
Jordan SD, Kriebs A, Vaughan M, Duglan D, Fan W, Henriksson E, Huber AL, Papp SJ, Nguyen M, Afetian M, Downes M, Yu RT, Kralli A, Evans RM, Lamia KA., Free PMC Article | 04/7/2018 |
| CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer. | CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA., Free PMC Article | 09/2/2017 |
| In vivo knockdown of Rfk, Riboflavin (vitamin B2) kinase essential for FAD synthesis, altered the expression rhythms of CRY1, CRY2, and PER1 | FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.
Hirano A, Braas D, Fu YH, Ptáček LJ., Free PMC Article | 05/6/2017 |
| The present study identified USP7 and TDP-43 as the regulators of CRY1 and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork. | USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka-Hata H, Lanjakornsiripan D, Fukada Y., Free PMC Article | 03/18/2017 |
| Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function. | Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.
Edwards MD, Brancaccio M, Chesham JE, Maywood ES, Hastings MH., Free PMC Article | 08/13/2016 |
| Data suggest that cryptochromes (Cry1 and Cry2) mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha). | CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock.
Tamaru T, Hattori M, Honda K, Nakahata Y, Sassone-Corsi P, van der Horst GT, Ozawa T, Takamatsu K., Free PMC Article | 05/28/2016 |
| Cry2 exerts a critical role in the control of depression-related emotional states and modulates the chronobiological gene expression profile in the mouse amygdala. | Anhedonic behavior in cryptochrome 2-deficient mice is paralleled by altered diurnal patterns of amygdala gene expression.
Savalli G, Diao W, Berger S, Ronovsky M, Partonen T, Pollak DD., Free PMC Article | 03/5/2016 |
| Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA. | Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.
Wang CY, Yeh JK, Shie SS, Hsieh IC, Wen MS. | 11/28/2015 |
| Data show that the intermolecular zinc finger is important for period circadian protein (PER2)-cryptochrome 2 (CRY2) complex formation. | Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.
Nangle SN, Rosensweig C, Koike N, Tei H, Takahashi JS, Green CB, Zheng N., Free PMC Article | 06/27/2015 |
| Report compression of daily activity time in Cry2 mutant mice. | Compression of daily activity time in mice lacking functional Per or Cry genes.
Spoelstra K, Comas M, Daan S. | 01/31/2015 |