| CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system. | CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system.
Hagen KM, Gordon P, Frederick A, Palmer AL, Edalat P, Zonta YR, Scott L, Flancia M, Reid JK, Joel M, Ousman SS. | 02/23/2024 |
| Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis. | Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.
Thomas OG, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Guerreiro-Cacais AO, Grönlund H, Olsson T, Kockum I., Free PMC Article | 06/7/2023 |
| HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage. | HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage.
Knapp J, Braunstein M, Berg SIT, Shirriff C., Free PMC Article | 12/24/2022 |
| The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice. | The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice.
Berg SIT, Knapp J, Braunstein M, Shirriff C. | 05/7/2022 |
| The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-beta (TGF-beta1)-Smad3/4 signaling. | The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling.
Wei T, Du Y, Shan T, Chen J, Shi D, Yang T, Wang J, Zhang J, Li Y., Free PMC Article | 05/7/2022 |
| Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury. | Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
Lim EF, Hoghooghi V, Hagen KM, Kapoor K, Frederick A, Finlay TM, Ousman SS., Free PMC Article | 11/22/2021 |
| alphaB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy. | αB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy.
Wang F, Jiang Z, Lou B, Duan F, Qiu S, Cheng Z, Ma X, Yang Y, Lin X., Free PMC Article | 09/25/2021 |
| The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing alphaB-crystallin expression. | The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression.
Wang L, Nie Q, Gao M, Yang L, Xiang JW, Xiao Y, Liu FY, Gong XD, Fu JL, Wang Y, Nguyen QD, Liu Y, Liu M, Li DW., Free PMC Article | 03/13/2021 |
| CRYAB promoted the proliferation and extracellular matrix production of chondrocytes, and inhibited chondrocytes apoptosis and cartilage degradation simultaneously. | αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
Bao Q, Yang D, Hong F, Yang J, Li L, Jin Y, Ma C. | 06/13/2020 |
| CRYAB regulates inflammatory response in intestinal mucosa by inhibiting IKKbeta-mediated signaling. | Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity.
Xu W, Guo Y, Huang Z, Zhao H, Zhou M, Huang Y, Wen D, Song J, Zhu Z, Sun M, Liu CY, Chen Y, Cui L, Wang X, Liu Z, Yang Y, Du P. | 05/2/2020 |
| IF and TFEB activation are clinically relevant therapeutic strategies to rescue advanced R120G alphaB-crystallin mutant-induced cardiomyopathy by normalizing desmin localization via autophagy-dependent and autophagy-independent mechanisms. | Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization.
Ma X, Mani K, Liu H, Kovacs A, Murphy JT, Foroughi L, French BA, Weinheimer CJ, Kraja A, Benjamin IJ, Hill JA, Javaheri A, Diwan A., Free PMC Article | 03/7/2020 |
| results reveal a novel function for extracellular CRYAB in the regulation of neuroinflammation; targeting extracellular CRYAB-modulated neuroinflammation is a potential therapeutic intervention for multiple sclerosis | Extracellular αB-crystallin modulates the inflammatory responses.
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW. | 06/15/2019 |
| chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates. | Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A., Free PMC Article | 04/13/2019 |
| Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it. | Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56.
Cui X, Han W, Li J, Feng R, Zhou Z, Han J, Li M, Wang S, Zhang W, Lei Q, Zhang J, Liu Y, Hu Y., Free PMC Article | 01/26/2019 |
| The neuroprotective properties of alpha-crystallin B further demonstrate the potential importance of crystallin proteins in developing therapeutic options for glaucoma. | The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model.
Anders F, Liu A, Mann C, Teister J, Lauzi J, Thanos S, Grus FH, Pfeiffer N, Prokosch V., Free PMC Article | 06/23/2018 |
| findings offer additional insight into the early transcriptional changes caused by Cryaa and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo | Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
Andley UP, Tycksen E, McGlasson-Naumann BN, Hamilton PD., Free PMC Article | 02/10/2018 |
| It plays a protective and beneficial role in the aging PNS. | AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system.
Lim EF, Musa A, Frederick A, Ousman SS. | 11/18/2017 |
| desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels. | Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Diokmetzidou A, Soumaka E, Kloukina I, Tsikitis M, Makridakis M, Varela A, Davos CH, Georgopoulos S, Anesti V, Vlahou A, Capetanaki Y., Free PMC Article | 08/5/2017 |
| this study shows the microglia clusters emerging during experimental autoimmune encephalomyelitis are associated with axonal damage and oligodendrocytes expressing heat-shock protein B5, but not lymphocytes | Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice.
Peferoen LA, Breur M, van de Berg S, Peferoen-Baert R, Boddeke EH, van der Valk P, Pryce G, van Noort JM, Baker D, Amor S., Free PMC Article | 05/13/2017 |
| This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter | Selective and compartmentalized myelin expression of HspB5.
Quraishe S, Wyttenbach A, Matinyarare N, Perry VH, Fern R, O'Connor V. | 10/22/2016 |
| alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone for SMAD4 and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration | αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.
Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton DR., Free PMC Article | 09/10/2016 |
| It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis. | Non-Hsp genes are essential for HSF1-mediated maintenance of whole body homeostasis.
Hayashida N., Free PMC Article | 06/28/2016 |
| A previously unrecognized link between c-Jun and Nrf2 transcription factors and redox-induced CRYAB expression in muscle cells. | Alpha B-crystallin induction in skeletal muscle cells under redox imbalance is mediated by a JNK-dependent regulatory mechanism.
Fittipaldi S, Mercatelli N, Dimauro I, Jackson MJ, Paronetto MP, Caporossi D. | 06/4/2016 |
| CryAB protects decidualization against stress conditions. | Crystallin αB acts as a molecular guard in mouse decidualization: regulation and function during early pregnancy.
Zuo RJ, Zhao YC, Lei W, Wang TS, Wang BC, Yang ZM. | 10/18/2014 |
| TNF-alpha-induced endothelial adhesion molecule expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased. | αB-crystallin/HspB5 regulates endothelial-leukocyte interactions by enhancing NF-κB-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin.
Dieterich LC, Huang H, Massena S, Golenhofen N, Phillipson M, Dimberg A., Free PMC Article | 05/3/2014 |