| Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers. | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers.
Chermon D, Birk R., Free PMC Article | 01/28/2023 |
| The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. | The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG.
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A. | 10/23/2021 |
| Association of the Variant rs7561317 Downstream of the TMEM18 Gene with Overweight/Obesity and Related Anthropometric Traits in a Sample of Pakistani Population. | Association of the Variant rs7561317 Downstream of the TMEM18 Gene with Overweight/Obesity and Related Anthropometric Traits in a Sample of Pakistani Population.
Rana S, Sultana A. | 11/21/2020 |
| Loci near TMEM18 (rs6548238), CDKAL1 (rs7754840), and FAIM2 (rs7138803) may be associated with obesity-related indicators, and loci near TMEM18 (rs6548238) and FAIM2 (rs7138803) may increase susceptibility of concurrent type 2 diabetes associated with obesity. | Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.
Kang J, Guan RC, Zhao Y, Chen Y., Free PMC Article | 05/9/2020 |
| results suggest that FTO alpha-ketoglutarate dependent dioxygenase, transmembrane protein 18, and fibronectin type III domain containing 5 genetic variants contribute to obesity susceptibility in children and adolescents | Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents.
Todendi PF, Klinger EI, Geraldo ACR, Brixner L, Reuter CP, Lindenau JDR, Valim ARM, Fiegenbaum M. | 11/2/2019 |
| Genetic variants in long-noncoding RNA AC092159.2 may contribute to gestational diabetes mellitus in a Chinese population by affecting TMEM18 expression. | Genetic Variants in AC092159.2 and Risk of Gestational Diabetes Mellitus in a Chinese Population.
Hu D, Miao W, Chen T, Xie K, Shi A, Zhang L, Li R, Wen J. | 10/19/2019 |
| TMEM18 gene is a potential biomarker for Acute Myeloid Leukemia | TMEM18: A Novel Prognostic Marker in Acute Myeloid Leukemia.
Ha M, Kim JY, Han ME, Kim GH, Park SY, Jeong DC, Oh SO, Kim YH. | 07/20/2019 |
| Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms. | Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 Variants.
Zlatohlavek L, Maratka V, Tumova E, Ceska R, Lanska V, Vrablik M, Hubacek JA., Free PMC Article | 01/5/2019 |
| Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes | Validation of obesity susceptibility loci identified by genome-wide association studies in early childhood in South Brazilian children.
Zandoná MR, Sangalli CN, Campagnolo PD, Vitolo MR, Almeida S, Mattevi VS. | 07/1/2017 |
| Genetic variants associated with BMI and WHR in adults influence growth patterns and general and abdominal fat development from early childhood onwards. | Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study.
Vogelezang S, Monnereau C, Gaillard R, Renders CM, Hofman A, Jaddoe VW, Felix JF. | 05/14/2016 |
| Studies indicate association of transmembrane protein 18 (TMEM18) variants within the proximal haplotype block with obesity and body mass. | Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity.
Rask-Andersen M, Sällman Almén M, Jacobsson JA, Ameur A, Moschonis G, Dedoussis G, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB., Free PMC Article | 04/9/2016 |
| FTO-rs9939609, TMEM18-rs6548238 and PCSK1-rs6234 polymorphisms are significantly associated with body mass index in a southern Chinese population. | Polymorphisms in FTO, TMEM18 and PCSK1 are associated with BMI in southern Chinese population.
Chen J, Yang M, Zhao K, Xu A, Huang Q. | 04/11/2015 |
| rs186019316 and rs7596758 in TMEM18 is associated with body mass index. | Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Liu CT, Young KL, Brody JA, Olden M, Wojczynski MK, Heard-Costa N, Li G, Morrison AC, Muzny D, Gibbs RA, Reid JG, Shao Y, Zhou Y, Boerwinkle E, Heiss G, Wagenknecht L, McKnight B, Borecki IB, Fox CS, North KE, Cupples LA., Free PMC Article | 04/4/2015 |
| TMEM18 mRNA expression levels are related to phenotypes of obesity and glucose metabolism. | Adipose tissue depot specific promoter methylation of TMEM18.
Rohde K, Keller M, Klös M, Schleinitz D, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Stumvoll M, Kovacs P, Blüher M, Böttcher Y. | 04/4/2015 |
| results add to the evidence that BMI related variants in and near FTO and TMEM18 may increase the risk for T2D not only through secondary effects of obesity | Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.
Kalnina I, Zaharenko L, Vaivade I, Rovite V, Nikitina-Zake L, Peculis R, Fridmanis D, Geldnere K, Jacobsson JA, Almen MS, Pirags V, Schiöth HB, Klovins J. | 11/2/2013 |
| By age 7, common variations in FTO, TMEM18 and NRXN3 influence the vulnerability to metabolic complications of sleep deprivation. | Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration.
Prats-Puig A, Grau-Cabrera P, Riera-Pérez E, Cortés-Marina R, Fortea E, Soriano-Rodríguez P, de Zegher F, Ibánez L, Bassols J, López-Bermejo A. | 09/21/2013 |
| In summary, moderately rare missense variants within the...TMEM18 genes observed in our study did not confer risk of common childhood obesity in African Americans... | The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.
Deliard S, Panossian S, Mentch FD, Kim CE, Hou C, Frackelton EC, Bradfield JP, Glessner JT, Zhang H, Wang K, Sleiman PM, Chiavacci RM, Berkowitz RI, Hakonarson H, Zhao J, Grant SF., Free PMC Article | 08/31/2013 |
| Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. | Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology.
Bernhard F, Landgraf K, Klöting N, Berthold A, Büttner P, Friebe D, Kiess W, Kovacs P, Blüher M, Körner A. | 06/15/2013 |
| TMEM18rs6548238 associated with risk of diabetes after adjustment for body mass index. | β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.
Thomsen M, Dahl M, Tybjærg-Hansen A, Nordestgaard BG. | 08/18/2012 |
| Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 | Implication of European-derived adiposity loci in African Americans.
Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MC., Free PMC Article | 06/23/2012 |
| Variants of TMEM18 and FTO are associated with obesity indices during puberty in Chinese children. | Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty.
Wang J, Mei H, Chen W, Jiang Y, Sun W, Li F, Fu Q, Jiang F. | 06/23/2012 |
| The polymorphisms rs6548238 and rs9935401 showed no association with educational level or income. | First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study.
Holzapfel C, Grallert H, Baumert J, Thorand B, Döring A, Wichmann HE, Hauner H, Illig T, Mielck A., Free PMC Article | 06/2/2012 |
| Our data suggest that SNPs in or near the TMEM18 locus contribute to obesity risk in the Greek population. | Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.
Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S, Vatin V, Durand E, Labrune Y, Delplanque J, Meyre D, Froguel P. | 05/26/2012 |
| We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r = 0.5694, P = 0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC. | Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.
Rask-Andersen M, Jacobsson JA, Moschonis G, Chavan RA, Sikder MA, Allzén E, Alsiö J, Chrousos GP, Manios Y, Fredriksson R, Schiöth HB., Free PMC Article | 05/12/2012 |
| TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner: perhaps this closed perinuclear localisation of TMEM18-bound DNA might repress transcription from it. | Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.
Jurvansuu JM, Goldman A., Free PMC Article | 01/28/2012 |