| In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase. | In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase.
Huang Z, Li Y, Konishi K, Sakai Y, Tashiro K, Fukami T, Borjigin J. | 07/23/2023 |
| AADAC promotes therapeutic activity of cisplatin and imatinib against ovarian cancer cells. | AADAC promotes therapeutic activity of cisplatin and imatinib against ovarian cancer cells.
Wang H, Wang D, Gu T, Zhu M, Cheng L, Dai W. | 10/29/2022 |
| Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer. | Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer.
Wang Y, Fang T, Wang Y, Yin X, Zhang L, Zhang X, Zhang D, Zhang Y, Wang X, Wang H, Xue Y., Free PMC Article | 06/18/2022 |
| Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients. | Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.
Levano KS, Jaramillo-Valverde L, Tarazona DD, Sanchez C, Capristano S, Vásquez-Loarte T, Solari L, Mendoza-Ticona A, Soto A, Rojas C, Zegarra-Chapoñan R, Guio H., Free PMC Article | 03/26/2022 |
| Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans. | Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans.
Sakai Y, Fukami T, Nagaoka M, Hirosawa K, Ichida H, Sato R, Suzuki K, Nakano M, Nakajima M. | 10/9/2021 |
| Study investigated the presence and activity of the AADAC enzyme in several human lungs. Results highlight high interindividual variability in both AADAC gene and protein expression as well as in phenacetin hydrolysis activity. These findings add more information to knowledge of pulmonary enzymes and could be particularly useful in the design and preclinical development of inhaled drugs. | Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs.
Gabriele M, Puccini P, Lucchi M, Aprile V, Gervasi PG, Longo V. | 05/30/2020 |
| AADAC rs1803155 single nucleotide polymorphism is associated with lower rifapentine clearance, leading to increased rifapentine exposure. | A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine.
Francis J, Zvada SP, Denti P, Hatherill M, Charalambous S, Mungofa S, Dawson R, Dorman S, Gupte N, Wiesner L, Jindani A, Harrison TS, Olagunju A, Egan D, Owen A, McIlleron HM., Free PMC Article | 03/14/2020 |
| that the AADAC gene c.361+1G>A variant may be a potential candidate factor for Tourette syndrome development | Association of the AADAC gene and Tourette syndrome in a Han Chinese cohort.
Yuan L, Zheng W, Yang Z, Deng X, Song Z, Deng H. | 12/22/2018 |
| Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1), NAT2 (N-acetyltransferase 2), AADAC (arylacetamide deacetylase), and CYP3A4 (cytochrome P450 3A4). | Identification of enzymes responsible for nitrazepam metabolism and toxicity in human.
Konishi K, Fukami T, Gotoh S, Nakajima M. | 08/19/2017 |
| Data suggest that AADAC in hepatocyte microsomes hydrolyzes ketoconazole, a synthetic imidazole antifungal agent, to N-deacetyl ketoconazole and thus triggers hepatocellular toxicity. | Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity.
Fukami T, Iida A, Konishi K, Nakajima M. | 05/13/2017 |
| AADAC deletion is a candidate susceptibility factor for Gilles de la Tourette Syndrome | Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.
Bertelsen B, Stefánsson H, Riff Jensen L, Melchior L, Mol Debes N, Groth C, Skov L, Werge T, Karagiannidis I, Tarnok Z, Barta C, Nagy P, Farkas L, Brøndum-Nielsen K, Rizzo R, Gulisano M, Rujescu D, Kiemeney LA, Tosato S, Nawaz MS, Ingason A, Unnsteinsdottir U, Steinberg S, Ludvigsson P, Stefansson K, Kuss AW, Paschou P, Cath D, Hoekstra PJ, Müller-Vahl K, Stuhrmann M, Silahtaroglu A, Pfundt R, Tümer Z. | 10/22/2016 |
| Translational N-glycosylation of AADAC plays a crucial role in regulating AADAC enzyme activity. | N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.
Muta K, Fukami T, Nakajima M, Yokoi T. | 03/22/2014 |
| Lipolysis of cellular TG and VLDL production were impaired in HCV infected cells during the early peak of viral infection. This was partially explained by an apparent deficiency of a putative TG lipase, arylacetamide deacetylase (AADAC). | Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.
Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD, Law LM, Chen C, Addison WR, Nelson R, Houghton M, Lehner R, Kneteman NM. | 03/8/2014 |
| An AADAC*3 allele yields decreased enzyme activity in liver microsomes. | A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.
Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T. | 03/9/2013 |
| human AADAC was the enzyme responsible for the deacetylation of rifamycins and would affect the induction rate of drug-metabolizing enzymes by rifamycins and their induced hepatotoxicity. | Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine.
Nakajima A, Fukami T, Kobayashi Y, Watanabe A, Nakajima M, Yokoi T. | 01/21/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. | 04/29/2009 |
| two intrinsic endoplasmic reticulum (ER) proteins, 11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD) and the 50-kDa esterase (E3), sharing some amino acid sequence motifs in their N-terminal transmembrane (TM) domains. | Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.
Mziaut H, Korza G, Hand AR, Gerard C, Ozols J. | 11/10/2005 |