| Monocytes release cystatin F dimer to associate with Abeta and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease. | Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease.
Li Q, Li B, Liu L, Wang KJ, Liu MY, Deng Y, Li Z, Zhao WD, Wu LY, Chen YH, Zhang K., Free PMC Article | 10/8/2024 |
| Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system. | Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system.
Syage AR, Pachow C, Murray KM, Henningfield C, Fernandez K, Du A, Cheng Y, Olivarria G, Kawauchi S, MacGregor GR, Green KN, Lane TE., Free PMC Article | 06/17/2024 |
| Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease. | Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.
Daniels MJD, Lefevre L, Szymkowiak S, Drake A, McCulloch L, Tzioras M, Barrington J, Dando OR, He X, Mohammad M, Sasaguri H, Saito T, Saido TC, Spires-Jones TL, McColl BW., Free PMC Article | 12/20/2023 |
| Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. | Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene.
Li J, Durose WW, Ito J, Kakita A, Iguchi Y, Katsuno M, Kunisawa K, Shimizu T, Ikenaka K. | 08/28/2021 |
| These results indicate that hypoxia BV2 cells highly express Cystatin F, which is involved in A2A R activation-mediated neuroinflammation via the PKA/CREB and PKC/CREB or ERK1/2 signaling pathways. | Cystatin F involvement in adenosine A(2A) receptor-mediated neuroinflammation in BV2 microglial cells.
Duan W, Wang H, Fan Q, Chen L, Huang H, Ran H., Free PMC Article | 11/2/2019 |
| High CST7 expression is associated with Alzheimer's disease. | RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J., Free PMC Article | 06/30/2018 |
| Our results validate cystatin F as a useful biomarker of early pathogenesis in experimental models of prion disease, and point to unexpected species-specific differences in the transcriptional responses to prion infections. | Cystatin F is a biomarker of prion pathogenesis in mice.
Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, Beerli RR, Bauer M, Saudan P, Dietmeier K, Lachmann I, Linnebank M, Martin R, Kallweit U, Kana V, Rushing EJ, Budka H, Aguzzi A., Free PMC Article | 08/19/2017 |
| During the active remyelinating phase, both CysF knockdown (CysFKD) and microglial-selective CatC overexpression (CatCOE) showed a worsening of the demyelination in Plp(4e/-) transgenic mice. Conversely, during the chronic demyelinating phase, CatC knockdown (CatCKD) ameliorated the demyelination. Our results suggest that the balance between CatC and CysF expression controls the demyelination and remyelination process. | The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K. | 05/7/2017 |
| The cystatin F expression in the activated microglia is closely associated with the effect of the A2A receptors, which may be related to the neuroinflammatory responses occurring during the pathological process. | Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion.
Duan W, Ran H, Zhou Z, He Q, Zheng J., Free PMC Article | 06/15/2013 |
| an inhibitory activity other than cystatin F quenches CatL activity in activated macrophages | Internalization of exogenous cystatin F supresses cysteine proteases and induces the accumulation of single-chain cathepsin L by multiple mechanisms.
Colbert JD, Matthews SP, Kos J, Watts C., Free PMC Article | 02/25/2012 |
| Expression of cystatin F indicates ongoing demyelination and remyelination; absence of cystatin F expression indicates cessation of remyelination in the demyelinating area. | Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination.
Ma J, Tanaka KF, Shimizu T, Bernard CC, Kakita A, Takahashi H, Pfeiffer SE, Ikenaka K. | 02/25/2012 |
| The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S. | The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S in mice.
Baston-Buest DM, Schanz A, Buest S, Fischer JC, Kruessel JS, Hess AP. | 07/12/2010 |