| Cathepsin B as a key regulator of ferroptosis in microglia following intracerebral hemorrhage. | Cathepsin B as a key regulator of ferroptosis in microglia following intracerebral hemorrhage.
Lu J, Li H, Yu Z, Cao C, Xu Z, Peng L, Zhang JH, Chen G. | 04/12/2024 |
| Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-kappaB / NLRP3 signaling pathway. | Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway.
Li H, Zhao Q, Liu D, Zhou B, Liao F, Chen L., Free PMC Article | 01/4/2024 |
| Cathepsin B knockout confers significant brain protection in the mouse model of stroke. | Cathepsin B knockout confers significant brain protection in the mouse model of stroke.
Hu K, Park Y, Olivas Y, Chen A, Liu C, Hu B. | 09/12/2023 |
| Exosome-derived miR-142-5p from liver stem cells improves the progression of liver fibrosis by regulating macrophage polarization through CTSB. | Exosome-derived miR-142-5p from liver stem cells improves the progression of liver fibrosis by regulating macrophage polarization through CTSB.
Hu Z, Zhao Y, Jiang J, Li W, Su G, Li L, Ran J. | 07/10/2023 |
| Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury. | Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Zhang Z, Pi R, Jiang Y, Ahmad M, Luo H, Luo J, Yang J, Sun B. | 05/12/2023 |
| Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-beta in hAbetaPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition. | Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition.
Hook G, Kindy M, Hook V., Free PMC Article | 05/9/2023 |
| Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses. | Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses.
Geisz A, Tran T, Orekhova A, Sahin-Tóth M., Free PMC Article | 03/29/2023 |
| Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice. | Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice.
Wen Z, Zhu H, Wu B, Zhang A, Wang H, Cheng Y, Zhao H, Li J, Liu M, Gao J., Free PMC Article | 02/10/2023 |
| Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity. | Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity.
Chen W, Imasaka M, Iwama H, Nishiura H, Ohmuraya M. | 11/26/2022 |
| S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders. | S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders.
Kim KR, Cho EJ, Eom JW, Oh SS, Nakamura T, Oh CK, Lipton SA, Kim YH., Free PMC Article | 11/5/2022 |
| Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation. | Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation.
Lian D, Zhu L, Yu Y, Zhang X, Lin Y, Liu J, Han R, Guo Y, Cai D, Xiao W, Chen Y, He H, Xu D, Zheng C, Wang X, Huang Y, Chen Y., Free PMC Article | 07/2/2022 |
| Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders. | Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V., Free PMC Article | 06/25/2022 |
| MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3. | MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3.
Zhang L, Qiu J, Shi J, Liu S, Zou H., Free PMC Article | 02/19/2022 |
| Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy. | Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy.
Mitrović A, Završnik J, Mikhaylov G, Knez D, Pečar Fonović U, Matjan Štefin P, Butinar M, Gobec S, Turk B, Kos J., Free PMC Article | 01/22/2022 |
| Cathepsin B Regulates Mice Granulosa Cells' Apoptosis and Proliferation In Vitro. | Cathepsin B Regulates Mice Granulosa Cells' Apoptosis and Proliferation In Vitro.
Chen C, Ahmad MJ, Ye T, Du C, Zhang X, Liang A, Yang L., Free PMC Article | 12/18/2021 |
| Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. | Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.
Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura KI, Suzuki C, Uchiyama Y, Hatano E, Ohmuraya M., Free PMC Article | 10/16/2021 |
| Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. | Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome.
Morrone C, Smirnova NF, Jeridi A, Kneidinger N, Hollauer C, Schupp JC, Kaminski N, Jenne D, Eickelberg O, Yildirim AÖ. | 08/21/2021 |
| Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins. | Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.
Meng J, Liu Y, Xie Z, Qing H, Lei P, Ni J. | 07/24/2021 |
| Cathepsin B is an executioner of ferroptosis. | Cathepsin B is an executioner of ferroptosis.
Nagakannan P, Islam MI, Conrad M, Eftekharpour E. | 07/17/2021 |
| Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis. | Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
Wang J, Wang L, Zhang X, Xu Y, Chen L, Zhang W, Liu E, Xiao C, Kou Q. | 06/12/2021 |
| Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling. | Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling.
Jiang M, Meng J, Zeng F, Qing H, Hook G, Hook V, Wu Z, Ni J., Free PMC Article | 03/13/2021 |
| The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. | The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
Gomez-Auli A, Hillebrand LE, Christen D, Günther SC, Biniossek ML, Peters C, Schilling O, Reinheckel T., Free PMC Article | 02/27/2021 |
| Target-Specific Imaging of Cathepsin and S100A8/A9 Reflects Specific Features of Malignancy and Enables Estimation of Tumor Malignancy. | Target-Specific Imaging of Cathepsin and S100A8/A9 Reflects Specific Features of Malignancy and Enables Estimation of Tumor Malignancy.
Helfen A, Große Hokamp N, Geyer C, Heindel W, Bremer C, Vogl T, Höltke C, Masthoff M, Barczyk-Kahlert K, Roth J, Wildgruber M, Eisenblaetter M. | 01/23/2021 |
| Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex. | Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex.
Viana GM, Gonzalez EA, Alvarez MMP, Cavalheiro RP, do Nascimento CC, Baldo G, D'Almeida V, de Lima MA, Pshezhetsky AV, Nader HB., Free PMC Article | 11/21/2020 |
| Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis. | Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
Fang W, Deng Z, Benadjaoud F, Yang C, Shi GP., Free PMC Article | 09/26/2020 |