| CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis. | CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis.
Zhang Y, Lui WY., Free PMC Article | 01/28/2023 |
| Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques. | Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
Nilchian A, Plant E, Parniewska MM, Santiago A, Rossignoli A, Skogsberg J, Hedin U, Matic L, Fuxe J., Free PMC Article | 04/3/2021 |
| the Cxadr-Adam10 complex might moderate TJ integrity/stability and play pivotal roles during early embryonic development. | The Cxadr-Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice.
Jeong Y, Ock SA, Yoo JG, Yu DY, Choi I. | 07/11/2020 |
| In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis. | CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor.
Zhang Z, Long C, Li X, Xie Q, Song M, Zhang Y., Free PMC Article | 06/1/2019 |
| In blastocysts, CAR was expressed at the cell contacts within the inner cell mass as well as in the trophectoderm (TE) where CAR was found together with ZO1 at the apical contacts, suggesting that CAR builds up apical TJs in TE and mediates cell adhesion in TE and inner cell mass. CAR was expressed in TE of implanting embryos as well as endometrial epithelium. | Coxsackievirus and Adenovirus Receptor, a Tight Junction Protein, in Peri-Implantation Mouse Embryos.
Oh YS, Nah WH, Choi B, Kim SH, Gye MC. | 10/28/2017 |
| Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction. | Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.
Lopez-Gordo E, Doszpoly A, Duffy MR, Coughlan L, Bradshaw AC, White KM, Denby L, Nicklin SA, Baker AH., Free PMC Article | 07/29/2017 |
| Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response | Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.
Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F., Free PMC Article | 03/5/2016 |
| the intracellular domain of CAR differentially regulates AdV entry and trafficking. Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family. | The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry.
Loustalot F, Kremer EJ, Salinas S., Free PMC Article | 11/7/2015 |
| Conclude that CXADR possesses no direct role in testicular physiology in vivo. | Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier.
Sultana T, Hou M, Stukenborg JB, Töhönen V, Inzunza J, Chagin AS, Sollerbrant K. | 01/17/2015 |
| with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction. | Down-regulation of coxsakie and adenovirus receptor during embryo implantation.
Li Y, Zhao H, Wang B, Cui D, Yuan S, He X, Guo N, Chen N. | 09/13/2014 |
| novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia | Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman RF, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, Dos Remedios CG, George AL Jr, Bishopric NH, Lodder EM, de Bakker JM, Fischer R, Coronel R, Wilde AA, Gotthardt M, Remme CA., Free PMC Article | 04/12/2014 |
| CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP. | The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).
Houri N, Huang KC, Nalbantoglu J., Free PMC Article | 04/5/2014 |
| These findings indicate that CAR plays an important role in the initiation of coxsackievirus B virus infections and is closely associated with hepatotropism and age-specific susceptibility. | Hepatic damage caused by coxsackievirus B3 is dependent on age-related tissue tropisms associated with the coxsackievirus-adenovirus receptor.
Liu JY, Wang SM, Chen IC, Yu CK, Liu CC. | 01/25/2014 |
| CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions. | Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice.
Mirza M, Pang MF, Zaini MA, Haiko P, Tammela T, Alitalo K, Philipson L, Fuxe J, Sollerbrant K., Free PMC Article | 09/22/2012 |
| CAR exerts important functions in the physiology of several organs in vivo | Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.
Pazirandeh A, Sultana T, Mirza M, Rozell B, Hultenby K, Wallis K, Vennström B, Davis B, Arner A, Heuchel R, Löhr M, Philipson L, Sollerbrant K., Free PMC Article | 10/1/2011 |
| Data show for the first time that CAR upregulation in the adult mouse heart induces cardiac inflammation reminiscent of early viral myocarditis. | The coxsackie-adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection.
Yuen S, Smith J, Caruso L, Balan M, Opavsky MA. | 08/6/2011 |
| increased CAR expression has a role in inducing cardiomyopathy | Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with beta-catenin signaling.
Caruso L, Yuen S, Smith J, Husain M, Opavsky MA. | 11/27/2010 |
| crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif | The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.
Verdino P, Witherden DA, Havran WL, Wilson IA., Free PMC Article | 10/4/2010 |
| Adoptive transfer of Tregs protected mice from coxsackievirus B3-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway. | Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway.
Shi Y, Fukuoka M, Li G, Liu Y, Chen M, Konviser M, Chen X, Opavsky MA, Liu PP. | 07/26/2010 |
| Blocking antibodies were found to inhibit neurite extension in retina organ and retinal explant cultures, whereas the application of extracellular CAR domains promoted neurite extension and adhesion to extracellular matrices. | The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.
Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG., Free PMC Article | 05/10/2010 |
| CAR activation dramatically improves fatty liver and ameliorates hyperglycemia. | Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD., Free PMC Article | 01/21/2010 |
| This manuscript demonstrates a unique role for CAR in the AV-node related to localization of connexin 45 to the cell-cell junction. Atrioventricular node block occurs in the absence CAR. | Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart.
Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU., Free PMC Article | 11/18/2009 |
| These results demonstrate a critical function for coxsackievirus and adenovirus receptor in the pathogenesis of group B coxsackievirus infection in vivo and in virus tropism for the heart and pancreas. | Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis.
Kallewaard NL, Zhang L, Chen JW, Guttenberg M, Sanchez MD, Bergelson JM., Free PMC Article | 01/21/2010 |
| it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis | CAR-associated vesicular transport of an adenovirus in motor neuron axons.
Salinas S, Bilsland LG, Henaff D, Weston AE, Keriel A, Schiavo G, Kremer EJ., Free PMC Article | 01/21/2010 |
| Results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle. | The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski U, Shi Y, Wrackmeyer U, Fischer R, Chen C, Schirdewan A, Jüttner R, Rathjen F, Poller W, Radke MH, Gotthardt M., Free PMC Article | 01/21/2010 |