| Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay. | Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay.
Gu N, Shen Y, He Y, Li C, Xiong W, Hu Y, Qiu Z, Peng F, Han W, Li C, Long X, Zhao R, Zhao Y, Shi B. | 09/30/2024 |
| Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity. | Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity.
Huang R, Duan J, Huang W, Cheng Y, Zhu B, Li F., Free PMC Article | 06/21/2024 |
| Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life. | Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life.
Onuzulu CD, Lee S, Basu S, Comte J, Hai Y, Hizon N, Chadha S, Fauni MS, Kahnamoui S, Xiang B, Halayko AJ, Dolinsky VW, Pascoe CD, Jones MJ., Free PMC Article | 11/1/2023 |
| Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. | Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Ondrová K, Zůvalová I, Vyhlídalová B, Krasulová K, Miková E, Vrzal R, Nádvorník P, Nepal B, Kortagere S, Kopečná M, Kopečný D, Šebela M, Rastinejad F, Pu H, Soural M, Rolfes KM, Haarmann-Stemmann T, Li H, Mani S, Dvořák Z., Free PMC Article | 06/2/2023 |
| Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. | Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis.
Ghosh S, Moorthy B, Haribabu B, Jala VR., Free PMC Article | 10/8/2022 |
| Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells. | Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells.
Taddese R, Roelofs R, Draper D, Wu X, Wu S, Swinkels DW, Tjalsma H, Boleij A., Free PMC Article | 12/18/2021 |
| Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-kappaB activation. | Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
Tian LX, Tang X, Ma W, Wang J, Zhang W, Liu K, Chen T, Zhu JY, Liang HP., Free PMC Article | 11/27/2021 |
| CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway. | CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Kyoreva M, Li Y, Hoosenally M, Hardman-Smart J, Morrison K, Tosi I, Tolaini M, Barinaga G, Stockinger B, Mrowietz U, Nestle FO, Smith CH, Barker JN, Di Meglio P., Free PMC Article | 11/22/2021 |
| Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients. | Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Liu L, Wang Q, Xie C, Xi N, Guo Z, Li M, Hou X, Xie N, Sun M, Li J, Chen X. | 09/11/2021 |
| Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study. | Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.
Alzahrani AM, Rajendran P. | 07/31/2021 |
| Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6. | Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Tian LX, Tang X, Zhu JY, Zhang W, Tang WQ, Yan J, Xu X, Liang HP. | 08/22/2020 |
| These results suggest that intracellular accumulation of serotonin (5-HT) via SERT induces CYP1A1 expression via AhR in intestinal epithelial cells, and SERT deficiency in vivo impairs activation of AhR. | Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR.
Manzella C, Singhal M, Alrefai WA, Saksena S, Dudeja PK, Gill RK., Free PMC Article | 10/12/2019 |
| Miroestrol suppressed beta-naphthoflavone increases in CYP1A1. | Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in β-naphthoflavone-treated mice by miroestrol.
Chatuphonprasert W, Jarukamjorn K, Putalun W. | 05/13/2017 |
| up-regulated expression during benzo(a)pyrene induced pulmonary carcinogenesis | Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression.
Bodduluru LN, Kasala ER, Madhana RM, Barua CC, Hussain MI, Haloi P, Borah P. | 10/1/2016 |
| Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1alpha induction. | Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α.
Kim HG, Han EH, Im JH, Lee EJ, Jin SW, Jeong HG. | 11/28/2015 |
| Our results support the hypothesis that CYP1A1 protects against hyperoxic lung injury by decreasing oxidative stress. | Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.
Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B., Free PMC Article | 10/24/2015 |
| Suggest an important role for CYP1A enzymes in the gender-specific modulation of hyperoxic lung injury. | Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.
Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B., Free PMC Article | 07/4/2015 |
| Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats. | Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
Holland PR, Pannozzo MA, Bastin ME, McNeilly AD, Ferguson KJ, Caughey S, Jansen MA, Merrifield GD, Marshall I, Mullins JJ, Wardlaw JM, Sutherland C, Horsburgh K., Free PMC Article | 04/11/2015 |
| CYP1A1 contributes to nitric oxide bioavailability and blood pressure regulation mediated by dietary omega-3 polyunsaturated fatty acids. | Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.
Agbor LN, Wiest EF, Rothe M, Schunck WH, Walker MK., Free PMC Article | 02/21/2015 |
| Aryl hydrocarbon receptor mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1. | Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression.
Vaas S, Kreft L, Schwarz M, Braeuning A. | 12/20/2014 |
| Suggest that CYP1A induction by coplanar polychlorinated/brominated biphenyls depends on AhR transcriptional activity and not on AhR expression. | In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother's milk in Japan.
Kakutani H, Aozasa O, Mizuno A, Akiyama E, Nakao T, Ohta S. | 11/8/2014 |
| Identify hepatic proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Solaimani P, Damoiseaux R, Hankinson O., Free PMC Article | 07/5/2014 |
| In livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of P450 oxidoreductase. | Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.
Stiborová M, Moserová M, Černá V, Indra R, Dračínský M, Šulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM. | 05/17/2014 |
| Reactive oxygen species production contributes to benzo[a]pyrene (BaP)-exacerbated atherosclerosis and CYP1A1 plays a protective role against oral BaP toxicity in aorta | Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.
Uno S, Sakurai K, Nebert DW, Makishima M. | 04/19/2014 |
| harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues | Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice.
El Gendy MA, El-Kadi AO., Free PMC Article | 11/16/2013 |